PMID- 31172725
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 11
IP  - 4
DP  - 2019 Jul
TI  - Association of Sensitization to Different Aeroallergens With Airway Function and 
      Nasal Patency in Urban Children.
PG  - 572-582
LID - 10.4168/aair.2019.11.4.572 [doi]
AB  - PURPOSE: Children with sensitization to aeroallergens have decreased lung 
      function and nasal patency. Our purpose was to determine the association of 
      sensitization to different aeroallergens with airway function and nasal patency. 
      METHODS: Four hundred and eighty-six randomly selected 11 year-old children who 
      lived in Seongnam City were examined. Serum specific immunoglobulin E (IgE) 
      levels against 6 common allergens (Dermatophagoidesfarinae, birch, cat, dog, 
      Japanese hop and Alternaria), impulse oscillometry (IOS) results for the 
      evaluation of airway dysfunction, and acoustic rhinometry for the determination 
      of nasal airway patency were obtained. RESULTS: IOS indicated that children 
      sensitized to Alternaria (n = 38, 7.8%) and dog dander (n = 69, 14.2%) had 
      decreased lung function, based on resistance at 10 Hz (Rrs10; abeta = 0.0072; 95% 
      CI, 0.017, 0.127; P = 0.010) and 1 Hz (Rrs1; abeta = 0.038; 95% CI, 0.001, 0.074; P 
      = 0.042). Children sensitized to D. farinae (n = 281, 57.8%) had decreased 
      post-decongestant nasal volume at 0 to 5 cm (abeta = -0.605; 95% CI, -1.005, -0.205; 
      P = 0.003), but normal IOS results at all measured frequencies (P > 0.05). 
      Increased serum eosinophil level was associated with Rrs1 (P = 0.007) and Rrs2 (P 
      = 0.018) and post-decongestant nasal volume at 0 to 5 cm (abeta = -0.885; 95% CI, 
      -1.331, -0.439; P < 0.001). CONCLUSIONS: Sensitivity to specific aeroallergens, 
      serum eosinophil count and total IgE level had different associations with upper 
      and lower airway dysfunction in urban children.
CI  - Copyright (c) 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Lee, Shinhae
AU  - Lee S
AUID- ORCID: 0000-0003-4122-9592
AD  - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of 
      Medicine, Seongnam, Korea.
FAU - Koh, Hyun Yong
AU  - Koh HY
AUID- ORCID: 0000-0002-3995-4341
AD  - Graduate School of Medical Science and Engineering, Korea Advanced Institute of 
      Science and Technology (KAIST), Daejeon, Korea.
FAU - Yon, Dong Keon
AU  - Yon DK
AUID- ORCID: 0000-0003-1628-9948
AD  - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of 
      Medicine, Seongnam, Korea.
AD  - Medical Service Corps, Republic of Korea Army, Seongnam, Korea.
FAU - Lee, Seung Won
AU  - Lee SW
AUID- ORCID: 0000-0001-5632-5208
AD  - Department of Data Science, Sejong University College of Software Convergence, 
      Seoul, Korea.
FAU - Ha, Eun Kyo
AU  - Ha EK
AUID- ORCID: 0000-0001-8863-5729
AD  - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of 
      Medicine, Seongnam, Korea.
FAU - Sung, Myongsoon
AU  - Sung M
AUID- ORCID: 0000-0002-6329-286X
AD  - Department of Pediatrics, Soon Chun Hyang University Gumi Hospital, Gumi, Korea.
FAU - Lee, Kyung Suk
AU  - Lee KS
AUID- ORCID: 0000-0002-6300-1348
AD  - Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University 
      College of Medicine, Guri, Korea.
FAU - Jee, Hye Mi
AU  - Jee HM
AUID- ORCID: 0000-0003-0128-065X
AD  - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of 
      Medicine, Seongnam, Korea.
FAU - Sheen, Youn Ho
AU  - Sheen YH
AUID- ORCID: 0000-0003-3227-5511
AD  - Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of 
      Medicine, Seoul, Korea.
FAU - Han, Man Yong
AU  - Han MY
AUID- ORCID: 0000-0002-9077-5779
AD  - Department of Pediatrics, CHA Bundang Medical Center, CHA University School of 
      Medicine, Seongnam, Korea. drmesh@gmail.com.
LA  - eng
GR  - Seongnam Atopy Project of the Seongnam City Government/Korea
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC6557775
OTO - NOTNLM
OT  - Lung function tests
OT  - allergens
OT  - eosinophil count
OT  - oscillometry
OT  - rhinometry
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2019/06/07 06:00
MHDA- 2019/06/07 06:01
PMCR- 2019/07/01
CRDT- 2019/06/08 06:00
PHST- 2018/12/18 00:00 [received]
PHST- 2019/04/08 00:00 [revised]
PHST- 2019/04/10 00:00 [accepted]
PHST- 2019/06/08 06:00 [entrez]
PHST- 2019/06/07 06:00 [pubmed]
PHST- 2019/06/07 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - 11.572 [pii]
AID - 10.4168/aair.2019.11.4.572 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2019 Jul;11(4):572-582. doi: 
      10.4168/aair.2019.11.4.572.