PMID- 31173912
OWN - NLM
STAT- MEDLINE
DCOM- 20200526
LR  - 20211204
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 24
IP  - 10
DP  - 2019 Oct
TI  - Revisiting mTOR inhibitors as anticancer agents.
PG  - 2086-2095
LID - S1359-6446(19)30079-0 [pii]
LID - 10.1016/j.drudis.2019.05.030 [doi]
AB  - The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine 
      kinase that regulates a variety of cellular processes, influencing diverse 
      pathological conditions including a variety of cancers. Accordingly, therapies 
      that target mTOR as anticancer agents benefit patients in various clinical 
      settings. It is therefore important to fully investigate mTOR signaling at a 
      molecular level and corresponding mTOR inhibitors to identify additional clinical 
      opportunities of targeting mTOR in cancers. In this review, we introduce the 
      function and regulation of the mTOR signaling pathway and organize and summarize 
      the different roles of mTOR in cancers and a variety of mTOR inhibitors that can 
      be used as anticancer agents. This article aims to enlighten and guide the 
      development of mTOR-targeted anticancer agents in the future.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Teng, Qiu-Xu
AU  - Teng QX
AD  - Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, 
      St John's University, Queens, NY 11439, USA.
FAU - Ashar, Yunali V
AU  - Ashar YV
AD  - Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, 
      St John's University, Queens, NY 11439, USA.
FAU - Gupta, Pranav
AU  - Gupta P
AD  - Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, 
      St John's University, Queens, NY 11439, USA.
FAU - Gadee, Eddie
AU  - Gadee E
AD  - Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, 
      St John's University, Queens, NY 11439, USA; Institute for Biotechnology, College 
      of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
FAU - Fan, Ying-Fang
AU  - Fan YF
AD  - Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, 
      St John's University, Queens, NY 11439, USA; Departments of Hepatobiliary 
      Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
FAU - Reznik, Sandra E
AU  - Reznik SE
AD  - Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, 
      St John's University, Queens, NY 11439, USA; Departments of Pathology and 
      Obstetrics and Gynecology and Women's Health, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA.
FAU - Wurpel, John N D
AU  - Wurpel JND
AD  - Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, 
      St John's University, Queens, NY 11439, USA.
FAU - Chen, Zhe-Sheng
AU  - Chen ZS
AD  - Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, 
      St John's University, Queens, NY 11439, USA. Electronic address: 
      chenz@stjohns.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190604
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Humans
MH  - Neoplasms/*drug therapy/metabolism
MH  - Protein Kinase Inhibitors/*therapeutic use
MH  - Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases/*antagonists & inhibitors/physiology
EDAT- 2019/06/08 06:00
MHDA- 2020/05/27 06:00
CRDT- 2019/06/08 06:00
PHST- 2019/02/28 00:00 [received]
PHST- 2019/05/04 00:00 [revised]
PHST- 2019/05/30 00:00 [accepted]
PHST- 2019/06/08 06:00 [pubmed]
PHST- 2020/05/27 06:00 [medline]
PHST- 2019/06/08 06:00 [entrez]
AID - S1359-6446(19)30079-0 [pii]
AID - 10.1016/j.drudis.2019.05.030 [doi]
PST - ppublish
SO  - Drug Discov Today. 2019 Oct;24(10):2086-2095. doi: 10.1016/j.drudis.2019.05.030. 
      Epub 2019 Jun 4.