PMID- 31174250
OWN - NLM
STAT- MEDLINE
DCOM- 20191119
LR  - 20211204
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 11
DP  - 2019 Jun 6
TI  - mTOR and Aging: An Old Fashioned Dress.
LID - 10.3390/ijms20112774 [doi]
LID - 2774
AB  - Aging is a physiologic/pathologic process characterized by a progressive 
      impairment of cellular functions, supported by the alterations of several 
      molecular pathways, leading to an increased cell susceptibility to injury. This 
      deterioration is the primary risk factor for several major human pathologies. 
      Numerous cellular processes, including genomic instability, telomere erosion, 
      epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, 
      mitochondrial dysfunction, stem cell exhaustion, and altered intercellular signal 
      transduction represent common denominators of aging in different organisms. 
      Mammalian target of rapamycin (mTOR) is an evolutionarily conserved nutrient 
      sensing protein kinase that regulates growth and metabolism in all eukaryotic 
      cells. Studies in flies, worms, yeast, and mice support the hypothesis that the 
      mTOR signalling network plays a pivotal role in modulating aging. mTOR is 
      emerging as the most robust mediator of the protective effects of various forms 
      of dietary restriction, which has been shown to extend lifespan and slow the 
      onset of age-related diseases across species. Herein we discuss the role of mTor 
      signalling network in the development of classic age-related diseases, focused on 
      cardiovascular system, immune response, and cancer.
FAU - Stallone, Giovanni
AU  - Stallone G
AD  - Department of Medical and Surgical Sciences, Nephrology, Dialysis and 
      Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, 
      Italy. giovanni.stallone@unifg.it.
FAU - Infante, Barbara
AU  - Infante B
AD  - Department of Medical and Surgical Sciences, Nephrology, Dialysis and 
      Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, 
      Italy. barbarinf@libero.it.
FAU - Prisciandaro, Concetta
AU  - Prisciandaro C
AD  - Department of Medical and Surgical Sciences, Nephrology, Dialysis and 
      Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, 
      Italy. concetta.prisciandaro@gmail.com.
FAU - Grandaliano, Giuseppe
AU  - Grandaliano G
AD  - Department of Medical and Surgical Sciences, Nephrology, Dialysis and 
      Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, 
      Italy. giuseppe.grandaliano@unifg.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190606
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Aging/genetics/*metabolism
MH  - Animals
MH  - Cardiovascular Diseases/*etiology
MH  - Evolution, Molecular
MH  - Humans
MH  - Immune System Diseases/*etiology
MH  - Neoplasms/*etiology
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
PMC - PMC6600378
OTO - NOTNLM
OT  - aging
OT  - cancer
OT  - cardiovascular system
OT  - immune system
OT  - mTOR
COIS- The authors declare no conflict of interest.
EDAT- 2019/06/09 06:00
MHDA- 2019/11/20 06:00
PMCR- 2019/06/01
CRDT- 2019/06/09 06:00
PHST- 2019/04/16 00:00 [received]
PHST- 2019/06/03 00:00 [revised]
PHST- 2019/06/04 00:00 [accepted]
PHST- 2019/06/09 06:00 [entrez]
PHST- 2019/06/09 06:00 [pubmed]
PHST- 2019/11/20 06:00 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - ijms20112774 [pii]
AID - ijms-20-02774 [pii]
AID - 10.3390/ijms20112774 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Jun 6;20(11):2774. doi: 10.3390/ijms20112774.