PMID- 31174252
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 12
IP  - 11
DP  - 2019 Jun 6
TI  - Alendronate Release from UHMWPE-Based Biomaterials in Relation to Particle Size 
      of the GUR Powder for Manufacturing.
LID - 10.3390/ma12111832 [doi]
LID - 1832
AB  - Ultra-high molecular weight polyethylene (UHMWPE) is widely used in 
      endoprosthetics and has been the subject of countless studies. This project 
      investigates the dependence of alendronate (AL) release on the molecular weight 
      of the UHMWPE used (GUR1020 and GUR1050). A 0.5 wt% AL was added to the UHMWPE 
      during the production of the moldings. In addition to the 14-day release tests, 
      biocompatibility tests such as live dead assay, cell proliferation assay (WST) 
      and Lactate dehydrogenase test (LDH) with MG-63 cells as well as a tensile test 
      according to DIN EN ISO 527 were carried out. The released AL concentration was 
      determined by HPLC. A continuous release of the AL was observed over the entire 
      period of 2 weeks. In addition, a correlation between molar mass and AL release 
      was demonstrated. The GUR1020 showed a release four times higher than the 
      GUR1050. Both materials have no negative influence on the proliferation of MG-63 
      cells. This was also confirmed in the live/dead assay by the increase in cell 
      count. No cytotoxicity was detected in the LDH test. The addition of 0.5 wt% AL 
      increased the elongation at break for GUR1020 by 23% and for GUR1050 by 49%. It 
      was demonstrated that the choice of UHMWPE has an influence on the release of AL. 
      The particle size in particular has a strong influence on the release behavior.
FAU - Seidenstuecker, Michael
AU  - Seidenstuecker M
AUID- ORCID: 0000-0001-6643-6358
AD  - G.E.R.N. Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics 
      and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty 
      of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 
      Freiburg, Germany. michael.seidenstuecker@uniklinik-freiburg.de.
FAU - Weber, Julia
AU  - Weber J
AD  - G.E.R.N. Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics 
      and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty 
      of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 
      Freiburg, Germany. juli-weber@hotmail.de.
AD  - Faculty Mechanical and Medical Engineering, Furtwangen University, 
      Robert-Gerwig-Platz 1, 78120 Furtwangen, Germany. juli-weber@hotmail.de.
FAU - Latorre, Sergio H
AU  - Latorre SH
AD  - G.E.R.N. Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics 
      and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty 
      of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 
      Freiburg, Germany. sergio.latorre@uniklinik-freiburg.de.
FAU - Straub, Brigitte
AU  - Straub B
AD  - Faculty Mechanical and Medical Engineering, Furtwangen University, 
      Robert-Gerwig-Platz 1, 78120 Furtwangen, Germany. sbr@hs-furtwangen.de.
FAU - Matthes, Ulrich
AU  - Matthes U
AD  - Freiburg Materials Research Center (FMF) and Institute for Macromolecular 
      Chemistry of the Albert-Ludwigs University Freiburg, Stefan-Meier-Str. 21, 
      D-79104 Freiburg, Germany. ulrich.matthes@fmf.uni-freiburg.de.
FAU - Friedrich, Christian
AU  - Friedrich C
AD  - Freiburg Materials Research Center (FMF) and Institute for Macromolecular 
      Chemistry of the Albert-Ludwigs University Freiburg, Stefan-Meier-Str. 21, 
      D-79104 Freiburg, Germany. christian.friedrich@fmf.uni-freiburg.de.
FAU - Mayr, Hermann O
AU  - Mayr HO
AD  - G.E.R.N. Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics 
      and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty 
      of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 
      Freiburg, Germany. hermann.mayr@uniklinik-freiburg.de.
FAU - Bernstein, Anke
AU  - Bernstein A
AD  - G.E.R.N. Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics 
      and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty 
      of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 
      Freiburg, Germany. anke.bernstein@uniklinik-freiburg.de.
LA  - eng
PT  - Journal Article
DEP - 20190606
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC6600958
OTO - NOTNLM
OT  - GUR1020
OT  - GUR1050
OT  - HPLC
OT  - UHMWPE
OT  - alendronate
OT  - aseptic loosening
OT  - drug release
OT  - osteoporosis
COIS- The authors state that they have no conflict of interest to declare.
EDAT- 2019/06/09 06:00
MHDA- 2019/06/09 06:01
PMCR- 2019/06/06
CRDT- 2019/06/09 06:00
PHST- 2019/05/21 00:00 [received]
PHST- 2019/06/03 00:00 [revised]
PHST- 2019/06/04 00:00 [accepted]
PHST- 2019/06/09 06:00 [entrez]
PHST- 2019/06/09 06:00 [pubmed]
PHST- 2019/06/09 06:01 [medline]
PHST- 2019/06/06 00:00 [pmc-release]
AID - ma12111832 [pii]
AID - materials-12-01832 [pii]
AID - 10.3390/ma12111832 [doi]
PST - epublish
SO  - Materials (Basel). 2019 Jun 6;12(11):1832. doi: 10.3390/ma12111832.