PMID- 31176081
OWN - NLM
STAT- MEDLINE
DCOM- 20200211
LR  - 20200211
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 43
DP  - 2019 Jun
TI  - A comparative study of childhood/adolescent and adult onset schizophrenia: does 
      the neurocognitive and psychosocial outcome differ?
PG  - 160-169
LID - S1876-2018(19)30059-0 [pii]
LID - 10.1016/j.ajp.2019.05.031 [doi]
AB  - AIMS & OBJECTIVES: The present study aimed to evaluate the neurocognitive 
      functioning and psychosocial outcome (in terms of social functioning, disability 
      and internalized stigma) in patients with schizophrenia with childhood/adolescent 
      onset (age of onset </=18 years) and adult onset (>18years) schizophrenia and to 
      evaluate the effect of neurocognitive impairment on the outcome variables in 
      patients with youth and adult onset schizophrenia. METHODOLOGY: 34 patients with 
      youth onset schizophrenia (Group-I) and 56 patients with adult onset 
      schizophrenia (Group-II), who were currently in clinical remission were assessed 
      on a comprehensive neurocognitive battery,Positive and Negative syndrome Scale 
      (PANSS), Global Assessment of Functioning Scale (GAF), Indian Disability 
      Evaluation and Assessment Scale (IDEAS),Social and Occupational Functioning 
      Assessment Scale (SOFS) and Internalised Stigma of Mental Illness Scale (ISMIS). 
      RESULTS: On neurocognitive domains (after adjusting for co-variates) significant 
      differences were noted between the two groups in terms of processing speed 
      (TMT-A; I > II; p-value -0.009), verbal fluency (COWA;I < II;p-value-0.001) and 
      cognitive flexibility (TMT-B; I > II; p -0.031). Compared to patients with adult 
      onset schizophrenia, patients with childhood & adolescent onset schizophrenia had 
      significantly higher PANSS negative score, higher disability in all domains of 
      IDEAS, poorer socio-occupational functioning, low global functioning and reported 
      more stigma in the domains of alienation and discrimination.In patients with 
      childhood & adolescent onset schizophrenia, higher deficits in the processing 
      speed and verbal fluency were associated with significantly lower 
      socio-occupational functioning and higher disability; higher executive 
      dysfunction was associated with higher internalized stigma. Among patients with 
      adult onset schizophrenia, higher disability was related to executive dysfunction 
      only and higher stigma was associated with poor cognitive processing, selective 
      attention and poor executive functioning. CONCLUSIONS: The present study suggests 
      that compared to adult onset schizophrenia, patients with childhood & adolescent 
      onset schizophrenia have more deficits in neurocognition, have higher level of 
      disability, poorer socio-occupational functioning and have higher level of 
      self-stigma.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Grover, Sandeep
AU  - Grover S
AD  - Department of Psychiatry, PGIMER, 160012, Chandigarh, India. Electronic address: 
      drsandeepg2002@yahoo.com.
FAU - Sahoo, Swapnajeet
AU  - Sahoo S
AD  - Department of Psychiatry, PGIMER, 160012, Chandigarh, India.
FAU - Nehra, Ritu
AU  - Nehra R
AD  - Department of Psychiatry, PGIMER, 160012, Chandigarh, India.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190520
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Cognitive Dysfunction/etiology/*physiopathology
MH  - Cross-Sectional Studies
MH  - Disability Evaluation
MH  - Employment
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mentally Ill Persons
MH  - Middle Aged
MH  - Psychomotor Performance/*physiology
MH  - Schizophrenia/complications/*physiopathology
MH  - *Self Concept
MH  - *Severity of Illness Index
MH  - *Social Skills
MH  - *Social Stigma
MH  - Young Adult
OTO - NOTNLM
OT  - Age of onset
OT  - Neurocognitive functioning
OT  - Outcome
OT  - Psychosocial
OT  - Schizophrenia
EDAT- 2019/06/09 06:00
MHDA- 2020/02/12 06:00
CRDT- 2019/06/09 06:00
PHST- 2019/01/13 00:00 [received]
PHST- 2019/04/21 00:00 [revised]
PHST- 2019/05/17 00:00 [accepted]
PHST- 2019/06/09 06:00 [pubmed]
PHST- 2020/02/12 06:00 [medline]
PHST- 2019/06/09 06:00 [entrez]
AID - S1876-2018(19)30059-0 [pii]
AID - 10.1016/j.ajp.2019.05.031 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2019 Jun;43:160-169. doi: 10.1016/j.ajp.2019.05.031. Epub 2019 
      May 20.