PMID- 31176706
OWN - NLM
STAT- MEDLINE
DCOM- 20210715
LR  - 20210715
IS  - 1878-0938 (Electronic)
IS  - 1878-0938 (Linking)
VI  - 21
IP  - 11
DP  - 2020 Nov
TI  - Fractional Flow Reserve as a Standard of Reference for Ischemia Early After ST 
      Elevation Myocardial Infarction.
PG  - 1411-1416
LID - S1553-8389(19)30253-2 [pii]
LID - 10.1016/j.carrev.2019.04.019 [doi]
AB  - BACKGROUND: The purpose of the present study was to assess the value of the 
      fractional flow reserve (FFR) of the infarct-related artery (IRA) early after ST 
      elevation myocardial infarction (STEMI) in detecting reversible ischemia. 
      METHODS: Single photon emission computed tomography (SPECT) at rest and after 
      dipyridamole stress, and within 24 hour FFR of the IRA was performed on 69 
      patients 3 to 7 days after STEMI. FFR was 0.80 or less in 61 (88.4%) of them. In 
      these patients, percutaneous coronary intervention (PCI) was performed, and a 
      second SPECT study was repeated within 14 days. RESULTS: SPECT showed reversible 
      ischemia in 36 (59%) of these 61 patients, and converted to negative in 29 of 
      them. Thus, the SPECT results of these 29 patients were defined as true positive 
      before angioplasty and true negative after angioplasty. Considering the 
      true-positive and true-negative SPECT results as the gold standard, the 
      sensitivity, specificity, and positive and negative predictive values of the FFR 
      of 0.80 or less compared to this gold standard were 96.7%, 100%, 100%, and 96.6%, 
      respectively (k = 0.97, P < 0.001). CONCLUSIONS: In the early phase after STEMI, 
      the reliability of FFR to determine residual ischemia in the IRA is very high in 
      those patients with true-positive SPECT before and true-negative SPECT after PCI.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Ghaemian, Ali
AU  - Ghaemian A
AD  - Mazandaran Cardiovascular Research Center, Mazandaran University of Medical 
      Sciences, Iran. Electronic address: a.ghaemian@mazums.ac.ir.
FAU - Yazdani, Jamshid
AU  - Yazdani J
AD  - Faculty of Health, Mazandaran University of Medical Sciences, Iran.
FAU - Farsavian, Ali Asghar
AU  - Farsavian AA
AD  - Mazandaran Cardiovascular Research Center, Mazandaran University of Medical 
      Sciences, Iran.
FAU - Golshani, Samad
AU  - Golshani S
AD  - Mazandaran Cardiovascular Research Center, Mazandaran University of Medical 
      Sciences, Iran.
FAU - Nabati, Maryam
AU  - Nabati M
AD  - Mazandaran Cardiovascular Research Center, Mazandaran University of Medical 
      Sciences, Iran.
FAU - Dabirian, Mozhdeh
AU  - Dabirian M
AD  - Mazandaran Cardiovascular Research Center, Mazandaran University of Medical 
      Sciences, Iran.
FAU - Jalalian, Rozita
AU  - Jalalian R
AD  - Mazandaran Cardiovascular Research Center, Mazandaran University of Medical 
      Sciences, Iran.
FAU - Abedi, Seyed Mohamad
AU  - Abedi SM
AD  - Department of Nuclear Medicine, Mazandaran University of Medical Sciences, Iran.
FAU - Mirjani, Bahareh
AU  - Mirjani B
AD  - Mazandaran Cardiovascular Research Center, Mazandaran University of Medical 
      Sciences, Iran.
LA  - eng
PT  - Journal Article
DEP - 20190424
PL  - United States
TA  - Cardiovasc Revasc Med
JT  - Cardiovascular revascularization medicine : including molecular interventions
JID - 101238551
SB  - IM
MH  - Coronary Angiography
MH  - *Fractional Flow Reserve, Myocardial
MH  - Humans
MH  - Ischemia
MH  - *Myocardial Ischemia
MH  - *Percutaneous Coronary Intervention
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - *ST Elevation Myocardial Infarction
OTO - NOTNLM
OT  - Fractional flow reserve
OT  - STEMI
OT  - Single vessel disease
COIS- Disclosures None.
EDAT- 2019/06/10 06:00
MHDA- 2021/07/16 06:00
CRDT- 2019/06/10 06:00
PHST- 2019/01/06 00:00 [received]
PHST- 2019/04/04 00:00 [revised]
PHST- 2019/04/17 00:00 [accepted]
PHST- 2019/06/10 06:00 [pubmed]
PHST- 2021/07/16 06:00 [medline]
PHST- 2019/06/10 06:00 [entrez]
AID - S1553-8389(19)30253-2 [pii]
AID - 10.1016/j.carrev.2019.04.019 [doi]
PST - ppublish
SO  - Cardiovasc Revasc Med. 2020 Nov;21(11):1411-1416. doi: 
      10.1016/j.carrev.2019.04.019. Epub 2019 Apr 24.