PMID- 31176902
OWN - NLM
STAT- MEDLINE
DCOM- 20190930
LR  - 20190930
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 233
DP  - 2019 Oct
TI  - PBDE serum concentration and preschool maturity of children from Slovakia.
PG  - 387-395
LID - S0045-6535(19)31206-8 [pii]
LID - 10.1016/j.chemosphere.2019.05.284 [doi]
AB  - Polybrominated diphenylethers (PBDEs) are persistent organic pollutants (POPs), 
      they are considered endocrine disruptors and can bioaccumulate in nature, and in 
      living tissue. Human exposure to and the presence of PBDEs in human samples is of 
      concern due to their potential health risks. Young children are one of the most 
      vulnerable populations to PBDE's potential health effects. Ninety-one serum 
      samples of 6-year-old children, residing in a contaminated location, due to 
      former production of polychlorinated biphenyls (PCBs), were analysed to examine 
      children's exposure to PBDEs in Slovakia. Median serum concentrations found for 
      individual PBDE congeners BDE-28(+33), -47, -99, -100, -153, -154 and -183 were 
      0.015, 0.184, 0.079, 0.046, 0.176, 0.014, and 0.097 ng g(-1) lipid weight, 
      respectively. Children's preschool maturity was measured using the Wechsler 
      Preschool and Primary Scale of Intelligence (WPPSI-III) test. In multivariate 
      analyses BDE-153 serum concentrations were significantly inversely associated 
      with WPPSI-III composite score (p = 0.011, beta = -23.6), while adjusting for 
      PCB-153 and sex. Significant negative associations were observed for BDE-153 
      serum concentrations (p = 0.002, beta = -29.8) and WPPSI-III composite score, after 
      controlling for PCB-118 and sex. Negative associations were also observed for 
      BDE-47, BDE-100 and BDE-153, with different individual WPPSI subtest scores, 
      after adjustment with PCB-153 and/or PCB-118 and sex. Serum concentrations of 
      PCB-153 and PCB-118 were not statistically significantly associated with 
      WPPSI-III composite score and individual subtest scores. These findings 
      demonstrate adverse effects of PBDE serum exposure on preschool maturity of 
      children, and PBDEs potentially negative impact on child neuropsychological 
      development.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Drobna, Beata
AU  - Drobna B
AD  - Department of Toxic Organic Pollutants, Faculty of Medicine, Slovak Medical 
      University in Bratislava, Slovakia. Electronic address: beata.drobna@szu.sk.
FAU - Fabisikova, Anna
AU  - Fabisikova A
AD  - Mass Spectrometry Centre, Faculty of Chemistry, University of Vienna, Austria.
FAU - Conka, Kamil
AU  - Conka K
AD  - Department of Toxic Organic Pollutants, Faculty of Medicine, Slovak Medical 
      University in Bratislava, Slovakia.
FAU - Gago, Frantisek
AU  - Gago F
AD  - Department of Toxic Organic Pollutants, Faculty of Medicine, Slovak Medical 
      University in Bratislava, Slovakia.
FAU - Oravcova, Petra
AU  - Oravcova P
AD  - Department of Toxic Organic Pollutants, Faculty of Medicine, Slovak Medical 
      University in Bratislava, Slovakia.
FAU - Wimmerova, Sona
AU  - Wimmerova S
AD  - Department of Biostatistical Analysis, Faculty of Public Health, Slovak Medical 
      University in Bratislava, Slovakia.
FAU - Oktapodas Feiler, Marina
AU  - Oktapodas Feiler M
AD  - Department of Public Health Sciences, University of Rochester School of Medicine 
      & Dentistry; Rochester, New York, USA.
FAU - Sovcikova, Eva
AU  - Sovcikova E
AD  - Institute of Psychology, Faculty of Medicine, Slovak Medical University in 
      Bratislava, Slovakia.
LA  - eng
PT  - Journal Article
DEP - 20190530
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polybrominated Biphenyls)
RN  - 0 (hexabrominated diphenyl ether 153)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
SB  - IM
MH  - Child Development/*drug effects
MH  - Child, Preschool
MH  - Endocrine Disruptors/*blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Male
MH  - Polybrominated Biphenyls/*blood
MH  - Slovakia
OTO - NOTNLM
OT  - Child
OT  - Neurobehavioral
OT  - PBDEs
OT  - Preschool maturity
OT  - Serum
EDAT- 2019/06/10 06:00
MHDA- 2019/10/01 06:00
CRDT- 2019/06/10 06:00
PHST- 2019/02/19 00:00 [received]
PHST- 2019/05/28 00:00 [revised]
PHST- 2019/05/29 00:00 [accepted]
PHST- 2019/06/10 06:00 [pubmed]
PHST- 2019/10/01 06:00 [medline]
PHST- 2019/06/10 06:00 [entrez]
AID - S0045-6535(19)31206-8 [pii]
AID - 10.1016/j.chemosphere.2019.05.284 [doi]
PST - ppublish
SO  - Chemosphere. 2019 Oct;233:387-395. doi: 10.1016/j.chemosphere.2019.05.284. Epub 
      2019 May 30.