PMID- 31177357
OWN - NLM
STAT- MEDLINE
DCOM- 20200430
LR  - 20200430
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 34
IP  - 5
DP  - 2019 Oct
TI  - Contribution of serotonergic and nitrergic pathways, as well as monoamine 
      oxidase-a and Na(+), K(+)-ATPase enzymes in antidepressant-like action of 
      ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide (BMMS).
PG  - 1313-1324
LID - 10.1007/s11011-019-00436-x [doi]
AB  - The present study investigated a possible antidepressant-like effect of 
      ((4-tert-butylcyclohexylidene)methyl) (4-methoxystyryl) sulfide (BMMS) by using 
      the forced swimming test (FST) and the tail suspension test (TST) in Swiss mice. 
      The contribution of serotoninergic, glutamatergic and nitrergic systems in the 
      antidepressant-like activity of BMMS was evaluated. We also examined the 
      involvement of monoamine oxidase (MAO)-A, MAO-B and Na(+), K(+)-ATPase activities 
      in prefrontal cortex of mice. BMMS, (0.1-10 mg/kg, intragastrically (i.g.)) and 
      fluoxetine (32 mg/kg, i.g.) decreased the immobility time in the FST and TST. The 
      anti-immobility effect of BMMS (10 mg/kg, i.g.) in the TST was prevented by the 
      pretreatment of mice with WAY100635 (0.1 mg/kg, subcutaneously (s.c.), a 5-HT(1A) 
      receptor antagonist), ketanserin (5 mg/kg, intraperitoneal (i.p.), a 5-HT(2A/2C) 
      receptor antagonist), and partially blocked by ondansetron (1 mg/kg, i.p., a 
      5-HT(3) receptor antagonist). The anti-immobility effect of BMMS (10 mg / kg, 
      i.g.) was not avoided by pretreatment with MK-801 (0.01 mg/kg, s.c. a 
      non-competitive N-methyl D-Aspartate (NMDA) receptor) in the TST. Pretreatment 
      with L-arginine (500 mg/kg, i.p., a nitric oxide precursor) reversed partially 
      the reduction in the immobility time elicited by BMMS (10 mg/kg, i.g.) in TST. 
      BMMS altered Na(+),K(+)-ATPase and MAO-A activities in prefrontal cortex of mice, 
      but was not able to change the MAO-B activity. In conclusion, BMMS exerted an 
      antidepressant-like effect in mice and serotonergic and nitrergic systems are 
      involved in the antidepressant-like action of compound. BMMS modulated MAO-A and 
      Na(+), K(+)- ATPase activities in prefrontal cortex of mice.
FAU - de Oliveira, Renata L
AU  - de Oliveira RL
AD  - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa 
      em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia 
      (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade 
      Federal de Pelotas, Campus Capao do Leao, Pelotas, RS, CEP 96010-900, Brazil.
FAU - Voss, Guilherme T
AU  - Voss GT
AD  - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa 
      em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia 
      (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade 
      Federal de Pelotas, Campus Capao do Leao, Pelotas, RS, CEP 96010-900, Brazil.
FAU - Paltian, Jaini J
AU  - Paltian JJ
AD  - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa 
      em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia 
      (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade 
      Federal de Pelotas, Campus Capao do Leao, Pelotas, RS, CEP 96010-900, Brazil.
FAU - Pinz, Mikaela P
AU  - Pinz MP
AD  - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa 
      em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia 
      (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade 
      Federal de Pelotas, Campus Capao do Leao, Pelotas, RS, CEP 96010-900, Brazil.
FAU - Torres, Marina Laura C P
AU  - Torres MLCP
AD  - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa 
      em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia 
      (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade 
      Federal de Pelotas, Campus Capao do Leao, Pelotas, RS, CEP 96010-900, Brazil.
FAU - Moreira, Michele P
AU  - Moreira MP
AD  - Programa de Pos-Graduacao em Nanociencias, Centro de Ciencias Tecnologicas, 
      Universidade Franciscana, Santa Maria, RS, CEP 97010-032, Brazil.
FAU - Dilelio, Marina C
AU  - Dilelio MC
AD  - Departamento de Quimica, Universidade Federal de Santa Maria, Santa Maria, RS, 
      CEP 97105-900, Brazil.
FAU - Silveira, Claudio C
AU  - Silveira CC
AD  - Departamento de Quimica, Universidade Federal de Santa Maria, Santa Maria, RS, 
      CEP 97105-900, Brazil.
FAU - Wilhelm, Ethel A
AU  - Wilhelm EA
AD  - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa 
      em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia 
      (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade 
      Federal de Pelotas, Campus Capao do Leao, Pelotas, RS, CEP 96010-900, Brazil. 
      ethelwilhelm@yahoo.com.br.
FAU - Luchese, Cristiane
AU  - Luchese C
AUID- ORCID: 0000-0001-6001-0532
AD  - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa 
      em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia 
      (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade 
      Federal de Pelotas, Campus Capao do Leao, Pelotas, RS, CEP 96010-900, Brazil. 
      cristiane_luchese@yahoo.com.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190608
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (((4-tert-butylcyclohexylidene)methyl) (4-methoxystyryl) sulfide)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Styrenes)
RN  - 0 (Sulfides)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 333DO1RDJY (Serotonin)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 1.4.3.4 (Monoamine Oxidase)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology/therapeutic use
MH  - Arginine/pharmacology
MH  - Behavior, Animal/drug effects
MH  - Depression/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Fluoxetine/pharmacology/therapeutic use
MH  - Hindlimb Suspension
MH  - Male
MH  - Mice
MH  - Monoamine Oxidase/metabolism
MH  - Motor Activity/drug effects
MH  - Nitric Oxide/*metabolism
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Serotonin/*metabolism
MH  - Serotonin Antagonists/pharmacology
MH  - Sodium-Potassium-Exchanging ATPase/metabolism
MH  - Styrenes/*pharmacology/therapeutic use
MH  - Sulfides/*pharmacology/therapeutic use
OTO - NOTNLM
OT  - Depression
OT  - K+-ATPase
OT  - Monoamine oxidase
OT  - Na+
OT  - Nitric oxide
OT  - Serotonin
OT  - Sulfur
EDAT- 2019/06/10 06:00
MHDA- 2020/05/01 06:00
CRDT- 2019/06/10 06:00
PHST- 2018/09/23 00:00 [received]
PHST- 2019/05/20 00:00 [accepted]
PHST- 2019/06/10 06:00 [pubmed]
PHST- 2020/05/01 06:00 [medline]
PHST- 2019/06/10 06:00 [entrez]
AID - 10.1007/s11011-019-00436-x [pii]
AID - 10.1007/s11011-019-00436-x [doi]
PST - ppublish
SO  - Metab Brain Dis. 2019 Oct;34(5):1313-1324. doi: 10.1007/s11011-019-00436-x. Epub 
      2019 Jun 8.