PMID- 31177926
OWN - NLM
STAT- MEDLINE
DCOM- 20200710
LR  - 20200710
IS  - 1568-5624 (Electronic)
IS  - 0920-5063 (Linking)
VI  - 30
IP  - 14
DP  - 2019 Oct
TI  - Polyethyleneimine and quaternized ammonium polyethyleneimine: the versatile 
      materials for combating bacteria and biofilms.
PG  - 1243-1259
LID - 10.1080/09205063.2019.1627650 [doi]
AB  - Bacterial infection has become a serious clinical concern due to the emergence of 
      drug-resistance and biofilm formation. Therefore, it is in great demand to 
      develop efficient antimicrobial agents to treat bacterial infection without using 
      antibiotics. Herein, we successfully prepared four quaternized ammonium PEI 
      (QPEI: PEI(1200)-C2, PEI(1200)-C4, PEI(1200)-C6 and PEI(1200)-C8) using the 
      commercial available PEI(1200). Both PEI and four QPEI presented broad-spectrum 
      antimicrobial activity against Gram-negative bacteria (E. coli, and P. 
      aeruginosa) and Gram-positive bacteria (B. amyloliquefaciens and S. aureus), 
      especially PEI(1200)-C6 showed the strongest antimicrobial activity with good 
      biocompatibility at the MIC concentrations. Besides, PEI(1200)-C6 showed 
      4-16-fold better antibacterial effect than PEI(1200), and fluorescent microscope 
      imaging demonstrated that both of them could efficiently eradicate biofilms 
      formed by four bacterial strains in vitro. As the accessible broad-spectrum 
      antibacterial agents, PEI(1200) and PEI(1200)-C6 are significant candidates to 
      treat bacterial infections or eradicate biofilms on indwelling medical devices.
FAU - Lan, Tianyu
AU  - Lan T
AUID- ORCID: 0000-0002-8288-2865
AD  - a School of Chemical Engineering , Guizhou Minzu University, University Town , 
      Guizhou , China.
FAU - Guo, Qianqian
AU  - Guo Q
AUID- ORCID: 0000-0001-8373-3530
AD  - b The Department of pharmaceutical Engineering (State Key Laboratory of Functions 
      and Applications of Medicinal Plants, the High Efficacy Application of Natural 
      Medicinal Resources Engineering Center of Guizhou Province, the Key Laboratory of 
      Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical 
      Sciences , Guizhou Medical University, University Town , Guizhou , China.
FAU - Shen, Xiangchun
AU  - Shen X
AD  - b The Department of pharmaceutical Engineering (State Key Laboratory of Functions 
      and Applications of Medicinal Plants, the High Efficacy Application of Natural 
      Medicinal Resources Engineering Center of Guizhou Province, the Key Laboratory of 
      Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical 
      Sciences , Guizhou Medical University, University Town , Guizhou , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190619
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 0 (Ammonium Compounds)
RN  - 0 (Anti-Bacterial Agents)
RN  - 9002-98-6 (Polyethyleneimine)
SB  - IM
MH  - Ammonium Compounds/*chemistry
MH  - Animals
MH  - Anti-Bacterial Agents/chemistry/pharmacology/toxicity
MH  - Biofilms/*drug effects
MH  - Mice
MH  - NIH 3T3 Cells
MH  - Polyethyleneimine/*chemistry/*pharmacology/toxicity
MH  - Pseudomonas aeruginosa/*drug effects/physiology
MH  - Staphylococcus aureus/*drug effects/physiology
OTO - NOTNLM
OT  - Polyethyleneimine
OT  - anti-biofilms
OT  - antibacterial activity
OT  - quaternized ammonium polyethyleneimine
EDAT- 2019/06/11 06:00
MHDA- 2020/07/11 06:00
CRDT- 2019/06/11 06:00
PHST- 2019/06/11 06:00 [pubmed]
PHST- 2020/07/11 06:00 [medline]
PHST- 2019/06/11 06:00 [entrez]
AID - 10.1080/09205063.2019.1627650 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2019 Oct;30(14):1243-1259. doi: 
      10.1080/09205063.2019.1627650. Epub 2019 Jun 19.