PMID- 31178548
OWN - NLM
STAT- MEDLINE
DCOM- 20200127
LR  - 20200127
IS  - 1348-2246 (Electronic)
IS  - 0910-6340 (Linking)
VI  - 35
IP  - 9
DP  - 2019 Sep 10
TI  - Introducing an Experimental Design Approach for Efficient Optimization of Chiral 
      Derivatization Conditions for D- and L-Glyceric Acids.
PG  - 1053-1056
LID - 10.2116/analsci.19N013 [doi]
AB  - A sensitive analytical method was developed for individual analyses of D- and 
      L-glyceric acids by chiral derivatization - liquid chromatography-tandem mass 
      spectrometry. To elucidate rapid and efficient optimization for derivatization we 
      newly introduced a concept of design of experiments (DOE). The optimization of 
      major 5 factors in the derivatization could be predicted with only 28 
      measurements. By applying DOE to optimization, the yields of desired derivatives 
      increased five-fold against before optimization.
FAU - Takayama, Takahiro
AU  - Takayama T
AD  - Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical 
      Sciences, University of Shizuoka.
FAU - Mizuno, Hajime
AU  - Mizuno H
AD  - Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical 
      Sciences, University of Shizuoka.
FAU - Toyo'oka, Toshimasa
AU  - Toyo'oka T
AD  - Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical 
      Sciences, University of Shizuoka.
FAU - Todoroki, Kenichiro
AU  - Todoroki K
AD  - Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical 
      Sciences, University of Shizuoka.
LA  - eng
PT  - Journal Article
DEP - 20190607
PL  - Switzerland
TA  - Anal Sci
JT  - Analytical sciences : the international journal of the Japan Society for 
      Analytical Chemistry
JID - 8511078
RN  - 0 (Glyceric Acids)
SB  - IM
MH  - Chromatography, Liquid/*methods
MH  - Glyceric Acids/analysis/*chemistry
MH  - Limit of Detection
MH  - Software
MH  - Stereoisomerism
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - D- and L-glyceric acid
OT  - Design of experiment
OT  - chiral derivatization
EDAT- 2019/06/11 06:00
MHDA- 2020/01/28 06:00
CRDT- 2019/06/11 06:00
PHST- 2019/06/11 06:00 [pubmed]
PHST- 2020/01/28 06:00 [medline]
PHST- 2019/06/11 06:00 [entrez]
AID - 10.2116/analsci.19N013 [doi]
PST - ppublish
SO  - Anal Sci. 2019 Sep 10;35(9):1053-1056. doi: 10.2116/analsci.19N013. Epub 2019 Jun 
      7.