PMID- 31178768
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 10
DP  - 2019
TI  - Global and Specific Profiles of Executive Functioning in Prodromal and Early 
      Psychosis.
PG  - 356
LID - 10.3389/fpsyt.2019.00356 [doi]
LID - 356
AB  - Objective: Numerous reports on neurocognitive functioning deficits in individuals 
      at clinical high risk (CHR) and first-episode psychosis (FEP) patients suggest 
      particular deficits in executive functioning (EF). However, to date, most of the 
      studies have administered a single or a few EF tests to participants, and few 
      investigations have examined the different components of EF to identify specific 
      subdomains of relative strength and weakness. Method: Forty CHR subjects, 85 FEP 
      patients, and 85 healthy controls (HCs) were assessed with a neuropsychological 
      battery to elucidate the profiles of EF in the subdomains of shift, attention, 
      fluency, and planning. Results: In the subdomains of shift, attention, and 
      fluency, CHR individuals and FEP patients showed deficits compared to HC. The 
      post hoc analysis revealed that CHR individuals had comparable attention shifting 
      and phonemic fluency compared to FEP. CHR showed intermediate deficits between 
      FEP and HCs in spatial working memory and semantic fluency, and the largest 
      effect size was observed in semantic fluency both for CHR and FEP. Conclusion: 
      Overall, the findings of this study, in addition to providing detailed profiles 
      of EF in prodromal and early psychosis patients, highlight the informative value 
      of the specific subdomains of semantic fluency and spatial working memory.
FAU - Hwang, Wu Jeong
AU  - Hwang WJ
AD  - Department of Brain and Cognitive Sciences, College of Natural Science, Seoul 
      National University, Seoul, South Korea.
FAU - Lee, Tae Young
AU  - Lee TY
AD  - Department of Psychiatry, College of Medicine, Seoul National University, Seoul, 
      South Korea.
FAU - Shin, Won-Gyo
AU  - Shin WG
AD  - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, South Korea.
FAU - Kim, Minah
AU  - Kim M
AD  - Department of Psychiatry, College of Medicine, Seoul National University, Seoul, 
      South Korea.
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South 
      Korea.
FAU - Kim, Jihyang
AU  - Kim J
AD  - Department of Psychiatry, College of Medicine, Seoul National University, Seoul, 
      South Korea.
FAU - Lee, Junhee
AU  - Lee J
AD  - Department of Psychiatry, College of Medicine, Seoul National University, Seoul, 
      South Korea.
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South 
      Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Brain and Cognitive Sciences, College of Natural Science, Seoul 
      National University, Seoul, South Korea.
AD  - Department of Psychiatry, College of Medicine, Seoul National University, Seoul, 
      South Korea.
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South 
      Korea.
AD  - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20190521
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC6537881
OTO - NOTNLM
OT  - clinical high risk
OT  - executive function
OT  - first-episode psychosis
OT  - neurocognition
OT  - psychosis
OT  - semantic fluency
OT  - spatial working memory
EDAT- 2019/06/11 06:00
MHDA- 2019/06/11 06:01
PMCR- 2019/05/21
CRDT- 2019/06/11 06:00
PHST- 2018/12/20 00:00 [received]
PHST- 2019/05/07 00:00 [accepted]
PHST- 2019/06/11 06:00 [entrez]
PHST- 2019/06/11 06:00 [pubmed]
PHST- 2019/06/11 06:01 [medline]
PHST- 2019/05/21 00:00 [pmc-release]
AID - 10.3389/fpsyt.2019.00356 [doi]
PST - epublish
SO  - Front Psychiatry. 2019 May 21;10:356. doi: 10.3389/fpsyt.2019.00356. eCollection 
      2019.