PMID- 31178903
OWN - NLM
STAT- MEDLINE
DCOM- 20200114
LR  - 20200309
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2019
DP  - 2019
TI  - Alterations of Interhemispheric Functional Connectivity and Degree Centrality in 
      Cervical Dystonia: A Resting-State fMRI Study.
PG  - 7349894
LID - 10.1155/2019/7349894 [doi]
LID - 7349894
AB  - BACKGROUND: Cervical dystonia (CD) is a neurological movement disorder 
      characterized by involuntary head and neck movements and postures. Reports on 
      microstructural and functional abnormalities in multiple brain regions not 
      limited to the basal ganglia have been increasing in patients with CD. However, 
      the neural bases of CD are unclear. This study is aimed at identifying cerebral 
      functional abnormalities in CD by using resting-state functional magnetic 
      resonance imaging (rs-fMRI). METHODS: Using rs-fMRI data, voxel-mirrored 
      homotopic connectivity (VMHC) and degree centrality were used to compare the 
      alterations of the rs-functional connectivity (FC) between 19 patients with CD 
      and 21 healthy controls. Regions showing abnormal FCs from two measurements were 
      the regions of interest for correlation analyses. RESULTS: Compared with healthy 
      controls, patients with CD exhibited significantly decreased VMHC in the 
      supplementary motor area (SMA), precuneus (PCu)/postcentral gyrus, and superior 
      medial prefrontal cortex (MPFC). Significantly increased degree centrality in the 
      right PCu and decreased degree centrality in the right lentiform nucleus and left 
      ventral MPFC were observed in the patient group compared with the control group. 
      Further correlation analyses showed that the VMHC values in the SMA were 
      negatively correlated with dystonia severity. CONCLUSION: Local abnormalities and 
      interhemispheric interaction deficits in the sensorimotor network (SMA, 
      postcentral gyrus, and PCu), default mode network (MPFC and PCu), and basal 
      ganglia may be the key characteristics in the pathogenesis mechanism of CD.
FAU - Jiang, Wenyan
AU  - Jiang W
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Lei, Yiwu
AU  - Lei Y
AD  - Department of Radiology, The First Affiliated Hospital, Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Wei, Jing
AU  - Wei J
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Yang, Lu
AU  - Yang L
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Wei, Shubao
AU  - Wei S
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Yin, Qiong
AU  - Yin Q
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Luo, Shuguang
AU  - Luo S
AUID- ORCID: 0000-0002-4082-6136
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi 530021, China.
FAU - Guo, Wenbin
AU  - Guo W
AUID- ORCID: 0000-0002-1626-2465
AD  - Department of Psychiatry, The Second Xiangya Hospital of Central South 
      University, Changsha, Hunan 410011, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190424
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
SB  - IM
MH  - Adult
MH  - Brain/*diagnostic imaging
MH  - Brain Mapping
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*diagnostic imaging
MH  - Torticollis/*diagnostic imaging
PMC - PMC6507243
EDAT- 2019/06/11 06:00
MHDA- 2020/01/15 06:00
PMCR- 2019/04/24
CRDT- 2019/06/11 06:00
PHST- 2018/10/23 00:00 [received]
PHST- 2019/02/19 00:00 [revised]
PHST- 2019/03/21 00:00 [accepted]
PHST- 2019/06/11 06:00 [entrez]
PHST- 2019/06/11 06:00 [pubmed]
PHST- 2020/01/15 06:00 [medline]
PHST- 2019/04/24 00:00 [pmc-release]
AID - 10.1155/2019/7349894 [doi]
PST - epublish
SO  - Neural Plast. 2019 Apr 24;2019:7349894. doi: 10.1155/2019/7349894. eCollection 
      2019.