PMID- 31179568
OWN - NLM
STAT- MEDLINE
DCOM- 20200214
LR  - 20200214
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 51
IP  - 8
DP  - 2019 Sep
TI  - Resveratrol supplementation improves DNA integrity and sperm parameters in 
      streptozotocin-nicotinamide-induced type 2 diabetic rats.
PG  - e13313
LID - 10.1111/and.13313 [doi]
AB  - Reproductive dysfunction is one of the diabetes complications. Resveratrol, a 
      polyphenol compound, shows antidiabetic and antioxidant effects. The aim of the 
      present study was to investigate the protective effects of resveratrol on sperm 
      parameters and chromatin quality in experimentally induced type 2 diabetes by 
      streptozotocin and nicotinamide. Forty male adult Wistar rats were grouped into 
      normal control, diabetic control and resveratrol-treated diabetic groups (1, 5 
      and 10 mg/kg orally treated for 30 days). Type 2 diabetes was induced using a 
      single dose of streptozotocin and nicotinamide by intraperitoneal injection. 
      Then, the different parameters and chromatin condensation of the epididymal 
      extracted spermatozoon were studied using aniline blue (AB), acridine orange (AO) 
      and toluidine blue (TB) staining. The sperm parameters including count, motility 
      and viability had significant reduction in diabetic rats (p < 0.05). Resveratrol 
      increased count, motility and viable spermatozoa relative to the diabetic group 
      (p < 0.05). The mean percentage of AB, AO and TB staining positive spermatozoa 
      was increased in diabetic groups compared to control (p < 0.001) and decreased 
      after treatment with 1 and 5 mg/kg resveratrol (p < 0.001). The results of AO and 
      TB staining showed that resveratrol did not have any beneficial effect on 
      chromatin condensation and denatured DNA at the dose of 10 mg/kg.
CI  - (c) 2019 Blackwell Verlag GmbH.
FAU - Bahmanzadeh, Maryam
AU  - Bahmanzadeh M
AUID- ORCID: 0000-0002-6585-9444
AD  - Endometrium and Endometriosis Research Center, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
AD  - Department of Anatomical sciences, School of medicine, Hamadan University of 
      Medical Sciences, Hamadan, Iran.
FAU - Goodarzi, Mohammad Taghi
AU  - Goodarzi MT
AUID- ORCID: 0000-0002-5546-5812
AD  - Department of Biochemistry, Shahrood Branch, Islamic Azad University, Shahrood, 
      Iran.
FAU - Rezaei Farimani, Azam
AU  - Rezaei Farimani A
AUID- ORCID: 0000-0002-7853-2993
AD  - Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, 
      Neyshabur, Iran.
FAU - Fathi, Nasibeh
AU  - Fathi N
AUID- ORCID: 0000-0002-5825-4092
AD  - Department of Anatomical sciences, School of medicine, Hamadan University of 
      Medical Sciences, Hamadan, Iran.
FAU - Alizadeh, Zohreh
AU  - Alizadeh Z
AUID- ORCID: 0000-0003-4490-3204
AD  - Endometrium and Endometriosis Research Center, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
AD  - Department of Anatomical sciences, School of medicine, Hamadan University of 
      Medical Sciences, Hamadan, Iran.
LA  - eng
GR  - 9311145896/Vice-chancellor for Research and Technology, Hamadan University of 
      Medical Sciences/
PT  - Journal Article
DEP - 20190609
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 0 (Antioxidants)
RN  - 0 (Chromatin)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 5W494URQ81 (Streptozocin)
RN  - 9007-49-2 (DNA)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antioxidants/*administration & dosage
MH  - Chromatin/drug effects/metabolism
MH  - Chromatin Assembly and Disassembly/drug effects
MH  - DNA/drug effects/metabolism
MH  - DNA Fragmentation/drug effects
MH  - Diabetes Mellitus, Experimental/chemically induced/complications
MH  - Diabetes Mellitus, Type 2/chemically induced/*complications
MH  - *Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Infertility, Male/etiology/pathology/*prevention & control
MH  - Male
MH  - Niacinamide/toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Resveratrol/*administration & dosage
MH  - Sperm Count
MH  - Sperm Motility/drug effects
MH  - Spermatozoa/drug effects/pathology
MH  - Streptozocin/toxicity
MH  - Treatment Outcome
OTO - NOTNLM
OT  - antioxidants
OT  - chromatin
OT  - diabetes mellitus
OT  - hyperglycaemia
OT  - male reproductive system
OT  - resveratrol
OT  - spermatozoon
EDAT- 2019/06/11 06:00
MHDA- 2020/02/15 06:00
CRDT- 2019/06/11 06:00
PHST- 2018/12/30 00:00 [received]
PHST- 2019/04/07 00:00 [revised]
PHST- 2019/04/17 00:00 [accepted]
PHST- 2019/06/11 06:00 [pubmed]
PHST- 2020/02/15 06:00 [medline]
PHST- 2019/06/11 06:00 [entrez]
AID - 10.1111/and.13313 [doi]
PST - ppublish
SO  - Andrologia. 2019 Sep;51(8):e13313. doi: 10.1111/and.13313. Epub 2019 Jun 9.