PMID- 31180948
OWN - NLM
STAT- MEDLINE
DCOM- 20200604
LR  - 20211204
IS  - 1728-7731 (Electronic)
IS  - 1726-4901 (Linking)
VI  - 82
IP  - 6
DP  - 2019 Jun
TI  - Magnesium-responsive genes are downregulated in diabetic patients after a 
      three-month exercise program on a bicycle ergometer.
PG  - 495-499
LID - 10.1097/JCMA.0000000000000112 [doi]
AB  - BACKGROUND: Exercise is an effective therapy for the management of diabetes 
      because it helps regulate glucose and magnesium homeostasis. Nevertheless, the 
      mechanisms by which exercise exerts effects on magnesium transport remain 
      unclear. This study investigated the expression of genes encoding magnesium 
      transporters (GMTs) after a three-month exercise program in diabetic patients. 
      METHODS: This study was conducted with a within-subject pre-post design. A total 
      of 15 adult patients with type 2 diabetes mellitus (T2DM) were recruited and 
      underwent a three-month indoor bicycle exercise program. The expression of five 
      GMTs (CNNM2, TRPM6, TRPM7, SLC41A1, and SLC41A3) was determined in blood samples. 
      Relevant anthropometric values and biochemical parameters were also determined. 
      RESULTS: Although the body weight and body mass index decreased after three 
      months exercise, there were no significant differences. Fasting blood glucose, 
      glycated hemoglobin (HbA1c), waist circumference, and magnesium levels decreased 
      after the exercise program (p < 0.05). The expression of SLC41A1 and SLC41A3 were 
      downregulated after exercise, but only CNNM2, TRPM6, and TRPM7 showed 
      significantly decreased expression levels compared with those before the exercise 
      program (p < 0.05). CONCLUSION: The three-month exercise program ameliorated 
      blood glucose levels and downregulated the expression of magnesium-responsive 
      genes in patients with T2DM.
FAU - Chiang, Yueh-Feng
AU  - Chiang YF
AD  - Department of Orthopedics, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical 
      Foundation, Taichung, Taiwan, ROC.
FAU - Chen, Hsuan-Ying
AU  - Chen HY
AD  - Orthopedics and Sports Medicine Laboratory, Changhua Christian Hospital, 
      Changhua, Taiwan, ROC.
FAU - Lee, I-Te
AU  - Lee IT
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
AD  - School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
FAU - Chien, Li-Sheng
AU  - Chien LS
AD  - Stem Cell Center, Department of Medical Research, Taichung Veterans General 
      Hospital, Taichung, Taiwan, ROC.
FAU - Huang, Jui-Hua
AU  - Huang JH
AD  - Stem Cell Center, Department of Medical Research, Taichung Veterans General 
      Hospital, Taichung, Taiwan, ROC.
FAU - Kolisek, Martin
AU  - Kolisek M
AD  - Institute of Veterinary-Physiology, Freies Universitat, Berlin, Germany.
FAU - Cheng, Fu-Chou
AU  - Cheng FC
AD  - Stem Cell Center, Department of Medical Research, Taichung Veterans General 
      Hospital, Taichung, Taiwan, ROC.
FAU - Tsai, Sen-Wei
AU  - Tsai SW
AD  - Department of Physical Medicine and Rehabilitation, Taichung Tzu Chi Hospital, 
      Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, ROC.
AD  - Department of Physical Medicine and Rehabilitation, School of Medicine, Tzu Chi 
      University, Hualien, Taiwan, ROC.
AD  - Ph.D. Program in Translational Medicine, National Chung Hsing University, 
      Taichung, Taiwan, ROC.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 0 (Blood Glucose)
RN  - 0 (CNNM2 protein, human)
RN  - 0 (Cation Transport Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (TRPM Cation Channels)
RN  - 0 (TRPM6 protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (TRPM7 protein, human)
RN  - I38ZP9992A (Magnesium)
SB  - IM
CIN - J Chin Med Assoc. 2019 Jul;82(7):527-528. PMID: 31094862
MH  - Blood Glucose/analysis
MH  - Cation Transport Proteins/genetics
MH  - Diabetes Mellitus, Type 2/*genetics/metabolism/therapy
MH  - Down-Regulation
MH  - Exercise Test
MH  - *Exercise Therapy
MH  - Female
MH  - Humans
MH  - Magnesium/*metabolism
MH  - Male
MH  - Membrane Transport Proteins/*genetics
MH  - Middle Aged
MH  - Prospective Studies
MH  - Protein Serine-Threonine Kinases/genetics
MH  - TRPM Cation Channels/genetics
EDAT- 2019/06/11 06:00
MHDA- 2020/06/05 06:00
CRDT- 2019/06/11 06:00
PHST- 2019/06/11 06:00 [entrez]
PHST- 2019/06/11 06:00 [pubmed]
PHST- 2020/06/05 06:00 [medline]
AID - 02118582-201906000-00011 [pii]
AID - 10.1097/JCMA.0000000000000112 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2019 Jun;82(6):495-499. doi: 10.1097/JCMA.0000000000000112.