PMID- 31181423
OWN - NLM
STAT- MEDLINE
DCOM- 20200707
LR  - 20200707
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 97
DP  - 2019 Aug
TI  - Predictors of meaningful improvement in quality of life after selective 
      amygdalohippocampectomy in Chinese patients with refractory temporal lobe 
      epilepsy: A prospective study.
PG  - 1-7
LID - S1525-5050(19)30260-4 [pii]
LID - 10.1016/j.yebeh.2019.05.006 [doi]
AB  - PURPOSE: Our aim was to determine the independent predictors of minimum 
      clinically important difference (MCID) in quality of life (QOL) after selective 
      amygdalohippocampectomy (SAH) among Chinese patients with refractory mesial 
      temporal lobe epilepsy (MTLE). METHODS: We conducted a prospective study and 
      enrolled 50 consecutive patients with refractory MTLE who underwent SAH after 
      their presurgical evaluations. The variables independently associated with MCID 
      in the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) overall score 1 year 
      after SAH were analyzed by multiple binary logistic regression analysis. RESULTS: 
      Significant improvements in the QOLIE-31 overall score and all subscale scores 
      were observed after SAH (p < 0.001). Among 50 patients with refractory MTLE, 78% 
      reached the criteria for MCID of QOL overall score after SAH. In the multiple 
      binary logistic regression model, the presurgical independent predictors of 
      significant improvement by MCID in QOL were absence of depression diagnosis 
      (adjusted odds ratio [OR] = 8.391, 95% confidence interval [CI] = 1.240-56.776, 
      p = 0.029) and good cognitive function (adjusted OR = 8.427, 95% 
      CI = 1.115-63.670, p = 0.039); the postoperative independent predictor was 
      seizure freedom (adjusted OR = 8.477, 95% CI = 1.195-60.122, p = 0.032). The 
      sensitivity and specificity for significant improvement in the QOL were 97.4% and 
      45.5% respectively, with an overall model accuracy of 86.0%. CONCLUSIONS: 
      Presurgical depression, cognitive function, and postsurgical seizure freedom are 
      independent predictors for meaningful improvement in QOL after SAH among the 
      Chinese patients with refractory MTLE. Preoperative evaluation of patients with 
      refractory MTLE should consider the cognitive dysfunction and psychological 
      disorders.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Qiu, Yinghui
AU  - Qiu Y
AD  - Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Department of Functional Neurosurgery, Ruijin Hospital affiliated to Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Yan, Yi
AU  - Yan Y
AD  - Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Functional Neurosurgery, Ruijin Hospital affiliated to Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Zhan, Shikun
AU  - Zhan S
AD  - Department of Functional Neurosurgery, Ruijin Hospital affiliated to Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Huang, Peng
AU  - Huang P
AD  - Department of Functional Neurosurgery, Ruijin Hospital affiliated to Shanghai 
      JiaoTong University School of Medicine, Shanghai, China.
FAU - Deng, Yulei
AU  - Deng Y
AD  - Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic 
      address: dyl10786@rjh.com.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190607
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Adult
MH  - Amygdala/*surgery
MH  - China
MH  - Cognition
MH  - Depressive Disorder/etiology/psychology
MH  - Epilepsy, Temporal Lobe/*surgery
MH  - Female
MH  - Hippocampus/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurosurgical Procedures/*methods
MH  - Prospective Studies
MH  - *Quality of Life/psychology
MH  - Young Adult
OTO - NOTNLM
OT  - Cognition
OT  - Depression
OT  - Epilepsy surgery
OT  - Predictors
OT  - Quality of life
EDAT- 2019/06/11 06:00
MHDA- 2020/07/08 06:00
CRDT- 2019/06/11 06:00
PHST- 2019/03/19 00:00 [received]
PHST- 2019/04/26 00:00 [revised]
PHST- 2019/05/08 00:00 [accepted]
PHST- 2019/06/11 06:00 [pubmed]
PHST- 2020/07/08 06:00 [medline]
PHST- 2019/06/11 06:00 [entrez]
AID - S1525-5050(19)30260-4 [pii]
AID - 10.1016/j.yebeh.2019.05.006 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2019 Aug;97:1-7. doi: 10.1016/j.yebeh.2019.05.006. Epub 2019 Jun 
      7.