PMID- 31183282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 11
IP  - 3
DP  - 2019 Mar 22
TI  - 25-hydroxy Vitamin D Levels in Pediatric Asthma Patients and its Link with Asthma 
      Severity.
PG  - e4302
LID - 10.7759/cureus.4302 [doi]
LID - e4302
AB  - Aim Although the relationship between 25-hydroxy (25-OH) vitamin D and asthma is 
      known, it is unknown if 25-OH vitamin D levels are correlated with asthma 
      severity in pediatric patients. The aim of this study was to compare the blood 
      25-OH vitamin D levels of asthma patients and healthy control groups and to 
      evaluate any correlation between asthma severity and blood 25-OH vitamin D levels 
      in pediatric asthma patients. Methods This is a cross-sectional study which shows 
      the 25-OH vitamin D levels of asthma patients and compared to healthy controls 
      followed by a tertiary pediatric clinic. We investigated the effect of 25-OH 
      vitamin D levels on the severity of asthma. The severity of asthma was determined 
      mainly by the duration of asthma diagnosis, a number of attacks in the previous 
      year, anti-inflammatory medication usage in a previous year, atopy presence in 
      the family, skin prick test positivity, and immunoglobulin E (IgE) levels of 
      asthma patients. Results Compared with control groups, asthma patients had 
      significantly lower 25-OH vitamin D, calcium (Ca) levels, and higher number of 
      patients who had a 25-OH vitamin D deficiency, (p<0.0001, p<0.0001, p<0.0001, 
      respectively). We found a correlation between blood 25-OH vitamin D levels and 
      force expiratory capacity in one second (FEV1) and forced vital capacity (FVC) 
      respectively (p< 0.001, r=0.512), (p< 0.001, r=0.513). There was an association 
      between FEV1, FVC and blood 25-OH vitamin D levels in terms of deficient levels 
      (<20 ng/mL) or insufficient levels (>/=20 and <30 ng/mL) (p<0.001, r=0.459), (p< 
      0.001, r=0.450), respectively. Conclusions The 25-OH vitamin D levels were lower 
      in pediatric asthma patients with worse spirometry results. Effects of Vitamin D 
      supplementation need to be evaluated by well-designed studies.
FAU - Ozturk Thomas, Gulten
AU  - Ozturk Thomas G
AD  - Pediatrics, Dr. Lutfi Kirdar Training & Research Hospital, Istanbul, TUR.
FAU - Tutar, Engin
AU  - Tutar E
AD  - Pediatrics, Dr. Lutfi Kirdar Training & Research Hospital, Istanbul, TUR.
FAU - Tokuc, Gulnur
AU  - Tokuc G
AD  - Pediatrics, Dr. Lutfi Kirdar Training & Research Hospital, Istanbul, TUR.
FAU - Oktem, Sedat
AU  - Oktem S
AD  - Pediatrics, Dr. Lutfi Kirdar Training & Research Hospital, Istanbul, TUR.
LA  - eng
PT  - Journal Article
DEP - 20190322
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC6538098
OTO - NOTNLM
OT  - 25-hydroxy vitamin d
OT  - asthma
OT  - disease severity
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/06/12 06:00
MHDA- 2019/06/12 06:01
PMCR- 2019/03/22
CRDT- 2019/06/12 06:00
PHST- 2019/06/12 06:00 [entrez]
PHST- 2019/06/12 06:00 [pubmed]
PHST- 2019/06/12 06:01 [medline]
PHST- 2019/03/22 00:00 [pmc-release]
AID - 10.7759/cureus.4302 [doi]
PST - epublish
SO  - Cureus. 2019 Mar 22;11(3):e4302. doi: 10.7759/cureus.4302.