PMID- 31183502
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20240210
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 75
IP  - 3
DP  - 2020 Feb 14
TI  - Audiometric Age-Related Hearing Loss and Cognition in the Hispanic Community 
      Health Study.
PG  - 552-560
LID - 10.1093/gerona/glz119 [doi]
AB  - BACKGROUND: Age-related hearing loss (HL), a common and treatable condition, has 
      been associated with other age-related conditions. Late life cognitive impairment 
      is a major public health concern that is rarely treatable. Studies examining the 
      relationship between HL and cognition have been limited by non-Hispanic cohorts, 
      small samples, or limited confounding control. We overcome these limitations in a 
      large Hispanic cohort. METHODS: This was a multisite cross-sectional study of 
      5,277 subjects at least 50 years old (Hispanic Community Health Study, HCHS). The 
      main exposure was audiometric HL. The main outcome measure was neurocognitive 
      performance ascertained by the Digit Symbol Substitution Test (DSST), Word 
      Frequency Test, Spanish-English Verbal Learning Test (SEVLT), and Six-Item 
      Screener. RESULTS: The mean age was 58.4 years (SD = 6.2). A 20-dB (equivalent to 
      a one-category worsening) increase in HL was associated with a -1.53 (95% CI, 
      -2.11, -0.94) raw score point difference in the DSST, adjusting for demographics, 
      hearing aid use, and cardiovascular disease. Similarly, a 20-dB increase in HL 
      was associated with a -0.86 (-1.23, -0.49) point difference on the Word Frequency 
      Test, -0.76 (-1.04, -0.47) on the SEVLT 3 trials, -0.45 (-0.60, -0.29) on the 
      SELVT recall, and -0.07 (-0.12, -0.02) on the Six-Item Screener. CONCLUSIONS: In 
      the largest study of formal, audiometric HL and cognition to date, HL was 
      independently associated with worse performance in a range of neurocognitive 
      measures. Because HL is common and potentially treatable, it should be 
      investigated as a modifiable risk factor for neurocognitive decline and dementia.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of The 
      Gerontological Society of America. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Golub, Justin S
AU  - Golub JS
AD  - Department of Otolaryngology-Head and Neck Surgery, Columbia University Irving 
      Medical Center, New York.
FAU - Brickman, Adam M
AU  - Brickman AM
AD  - Department of Neurology, the Taub Institute for Research on Alzheimer's Disease 
      and the Aging Brain, and the Gertrude H. Sergievsky Center, Vagelos College of 
      Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical 
      Center, New York.
FAU - Ciarleglio, Adam J
AU  - Ciarleglio AJ
AD  - Department of Epidemiology and Biostatistics, Milken Institute School of Public 
      Health, George Washington University, Washington, DC.
FAU - Schupf, Nicole
AU  - Schupf N
AD  - Department of Neurology, the Taub Institute for Research on Alzheimer's Disease 
      and the Aging Brain, and the Gertrude H. Sergievsky Center, Vagelos College of 
      Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical 
      Center, New York.
AD  - Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia 
      University, New York.
FAU - Luchsinger, Jose A
AU  - Luchsinger JA
AD  - Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia 
      University, New York.
AD  - Department of Medicine, Vagelos College of Physicians and Surgeons, 
      NewYork-Presbyterian/Columbia University Irving Medical Center, New York.
LA  - eng
GR  - K23 AG057832/AG/NIA NIH HHS/United States
GR  - K24 AG045334/AG/NIA NIH HHS/United States
GR  - L30 AG060513/AG/NIA NIH HHS/United States
GR  - R01 AG062624/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Audiometry
MH  - Cognitive Dysfunction/*etiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hearing Loss/*complications/*diagnosis
MH  - Hispanic or Latino
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - United States
PMC - PMC7328204
OTO - NOTNLM
OT  - Aging
OT  - Audiometry
OT  - Cognitive impairment
OT  - Presbycusis
EDAT- 2019/06/12 06:00
MHDA- 2020/11/21 06:00
PMCR- 2020/06/11
CRDT- 2019/06/12 06:00
PHST- 2018/12/02 00:00 [received]
PHST- 2019/06/12 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2019/06/12 06:00 [entrez]
PHST- 2020/06/11 00:00 [pmc-release]
AID - 5513489 [pii]
AID - glz119 [pii]
AID - 10.1093/gerona/glz119 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2020 Feb 14;75(3):552-560. doi: 
      10.1093/gerona/glz119.