PMID- 31183602
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200225
IS  - 1573-7373 (Electronic)
IS  - 0167-594X (Linking)
VI  - 144
IP  - 1
DP  - 2019 Aug
TI  - Smoking status and perioperative adverse events in patients undergoing cranial 
      tumor surgery.
PG  - 97-105
LID - 10.1007/s11060-019-03206-y [doi]
AB  - INTRODUCTION: Smoking is agreed to be a major health risk factor, but it is 
      debated whether it has an influence on perioperative adverse events (AEs) in 
      elective cranial tumor surgery. METHODS: We analyzed the 2013-2016 data from our 
      prospective institutional patient registry. Consecutive patients undergoing 
      elective microsurgical tumor surgery of a glioma or a meningioma were included. 
      Patients were categorized as active smokers, former smokers, and non-smokers. AE 
      were graded by the therapy-oriented Clavien-Dindo scale. Possible predictors of 
      postoperative AE were identified with the help of a binomial logistic regression 
      model. RESULTS: We identified 798 patients, out of which 480 were non-smokers, 
      193 active smokers, and 125 former smokers. The rate of AEs for active smokers 
      (30%, 95% CI [23-37%]) was indistinguishable from the AE rate of non-smokers 
      (32%, 95% CI [28-37%]). No difference between smoking status was found looking at 
      all AE individually, the odds ratio of suffering from local AE and systemic AE 
      respectively were the same between all smoking groups. The modified Rankin scale 
      at hospital admission was a strong and significant predictor of postoperative AE 
      (P = 0.013). CONCLUSIONS: Active smoking was not associated with an increased 
      risk for postoperative AE, neither looking at the total number of AE nor looking 
      at individual AE. Smoking status should therefore not be a major factor in 
      preoperative decision making. Although not based on data of this study, doctors 
      should always encourage patients to stop smoking due to its well-known 
      detrimental health effect.
FAU - Padevit, Luis
AU  - Padevit L
AD  - Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 
      8091, Zurich, Switzerland.
FAU - Sarnthein, Johannes
AU  - Sarnthein J
AD  - Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 
      8091, Zurich, Switzerland.
FAU - Stienen, Martin Nikolaus
AU  - Stienen MN
AD  - Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 
      8091, Zurich, Switzerland.
FAU - Krayenbuhl, Niklaus
AU  - Krayenbuhl N
AD  - Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 
      8091, Zurich, Switzerland.
FAU - Bozinov, Oliver
AU  - Bozinov O
AD  - Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 
      8091, Zurich, Switzerland.
FAU - Regli, Luca
AU  - Regli L
AD  - Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 
      8091, Zurich, Switzerland.
FAU - Neidert, Marian Christoph
AU  - Neidert MC
AUID- ORCID: 0000-0003-2828-4706
AD  - Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, 
      8091, Zurich, Switzerland. marian.neidert@usz.ch.
LA  - eng
PT  - Journal Article
DEP - 20190611
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Glioma/pathology/*surgery
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Meningeal Neoplasms/pathology/*surgery
MH  - Meningioma/pathology/*surgery
MH  - Middle Aged
MH  - Neurosurgical Procedures/*adverse effects
MH  - Outcome Assessment, Health Care
MH  - Postoperative Complications/*etiology
MH  - Prospective Studies
MH  - Risk Factors
MH  - Skull Neoplasms/pathology/*surgery
MH  - Smoking/*adverse effects
MH  - Survival Rate
OTO - NOTNLM
OT  - AE
OT  - Adverse events
OT  - Brain tumor
OT  - Glioma
OT  - Meningioma
OT  - Smoking
EDAT- 2019/06/12 06:00
MHDA- 2020/01/07 06:00
CRDT- 2019/06/12 06:00
PHST- 2019/03/14 00:00 [received]
PHST- 2019/06/04 00:00 [accepted]
PHST- 2019/05/31 00:00 [revised]
PHST- 2019/06/12 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/06/12 06:00 [entrez]
AID - 10.1007/s11060-019-03206-y [pii]
AID - 10.1007/s11060-019-03206-y [doi]
PST - ppublish
SO  - J Neurooncol. 2019 Aug;144(1):97-105. doi: 10.1007/s11060-019-03206-y. Epub 2019 
      Jun 11.