PMID- 31183867
OWN - NLM
STAT- MEDLINE
DCOM- 20191014
LR  - 20191014
IS  - 1750-3841 (Electronic)
IS  - 0022-1147 (Linking)
VI  - 84
IP  - 7
DP  - 2019 Jul
TI  - Cold-pressed Canola Oil Reduces Hepatic Steatosis by Modulating Oxidative Stress 
      and Lipid Metabolism in KM Mice Compared with Refined Bleached Deodorized Canola 
      Oil.
PG  - 1900-1908
LID - 10.1111/1750-3841.14504 [doi]
AB  - The quality of canola oil is affected by different extraction methods. The effect 
      of cold-pressed canola oil (CPCO) diet and traditional refined bleached 
      deodorized canola oil (RBDCO) diet on lipid accumulation and hepatic steatosis in 
      mice were investigated. The body weight, peroxisome proliferator-activated 
      receptor-alpha concentration, serum lipid profile, insulin sensitivity, and oxidative 
      stress were increased in mice fed with CPCO diet, which had higher unsaturated 
      fatty acid, tocopherols, phytosterols, and phospholipids but lower saturated 
      fatty acid than RBDCO, after 12 weeks,. Moreover, CPCO significantly increased 
      tocopherols and phytosterols content in liver and reduced liver cholesterol 
      contents and lipid vacuoles accumulation than RBDCO. Also, serum proinflammatory 
      cytokines, 3-hydroxy-3-methylglutary coenzyme A reductase expression level, 
      lipogenic enzymes, and transcriptional factors such as sterol regulatory 
      element-binding proteins 1c, acetyl-CoA carboxylase, and fatty acid synthase in 
      the liver were also markedly downregulated from CPCO diet mice. Overall, CPCO can 
      reduce lipid accumulation and hepatic steatosis by regulating oxidative stress 
      and lipid metabolism in Kun Ming mice compared with RBDCO. PRACTICAL APPLICATION: 
      The results suggested that more bioactive components were contained in 
      cold-pressed canola oil (CPCO) rather than refined bleached deodorized canola oil 
      (RBDCO). CPCO could lower the risk of obesity and hyperlipidemia, reduce lipid 
      accumulation, and prevent hepatic steatosis. It could be considered as a kind of 
      better edible oil than RBDCO.
CI  - (c) 2019 Institute of Food Technologists(R).
FAU - Zhou, Ying-Jun
AU  - Zhou YJ
AUID- ORCID: 0000-0003-3631-4004
AD  - The State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East 
      China Univ. of Science and Technology, Xuhui District, Shanghai, China.
FAU - Chang, Ya-Ning
AU  - Chang YN
AUID- ORCID: 0000-0003-4415-8064
AD  - The State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East 
      China Univ. of Science and Technology, Xuhui District, Shanghai, China.
FAU - You, Jia-Qi
AU  - You JQ
AD  - The State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East 
      China Univ. of Science and Technology, Xuhui District, Shanghai, China.
FAU - Li, Sui-Zi
AU  - Li SZ
AD  - The State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East 
      China Univ. of Science and Technology, Xuhui District, Shanghai, China.
FAU - Zhuang, Wei
AU  - Zhuang W
AD  - The State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East 
      China Univ. of Science and Technology, Xuhui District, Shanghai, China.
FAU - Cao, Cheng-Jia
AU  - Cao CJ
AD  - The State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East 
      China Univ. of Science and Technology, Xuhui District, Shanghai, China.
LA  - eng
GR  - Qinghai Science and Technology Department Grant/
PT  - Comparative Study
PT  - Journal Article
DEP - 20190610
PL  - United States
TA  - J Food Sci
JT  - Journal of food science
JID - 0014052
RN  - 0 (Fatty Acids)
RN  - 0 (PPAR alpha)
RN  - 0 (Phospholipids)
RN  - 0 (Rapeseed Oil)
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 2.3.1.85 (Fatty Acid Synthases)
RN  - EC 6.4.1.2 (Acetyl-CoA Carboxylase)
SB  - IM
MH  - Acetyl-CoA Carboxylase/genetics/metabolism
MH  - Animals
MH  - Cholesterol/metabolism
MH  - Fatty Acid Synthases/genetics/metabolism
MH  - Fatty Acids/analysis
MH  - Fatty Liver/*diet therapy/genetics/metabolism/physiopathology
MH  - Humans
MH  - Insulin Resistance
MH  - *Lipid Metabolism
MH  - Lipogenesis
MH  - Liver/metabolism
MH  - Male
MH  - Mice
MH  - *Oxidative Stress
MH  - PPAR alpha/genetics/metabolism
MH  - Phospholipids/metabolism
MH  - Rapeseed Oil/*chemistry/*metabolism
MH  - Sterol Regulatory Element Binding Protein 1/genetics/metabolism
MH  - Triglycerides/metabolism
OTO - NOTNLM
OT  - cold-pressed canola oil
OT  - hepatic lipid metabolism
OT  - lipid metabolism
OT  - refined bleached deodorized canola oil
EDAT- 2019/06/12 06:00
MHDA- 2019/10/15 06:00
CRDT- 2019/06/12 06:00
PHST- 2018/06/19 00:00 [received]
PHST- 2019/01/15 00:00 [revised]
PHST- 2019/02/14 00:00 [accepted]
PHST- 2019/06/12 06:00 [pubmed]
PHST- 2019/10/15 06:00 [medline]
PHST- 2019/06/12 06:00 [entrez]
AID - 10.1111/1750-3841.14504 [doi]
PST - ppublish
SO  - J Food Sci. 2019 Jul;84(7):1900-1908. doi: 10.1111/1750-3841.14504. Epub 2019 Jun 
      10.