PMID- 31185252
OWN - NLM
STAT- MEDLINE
DCOM- 20200305
LR  - 20221207
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Print)
IS  - 0195-6663 (Linking)
VI  - 141
DP  - 2019 Oct 1
TI  - Associations of childhood trauma with food addiction and insulin resistance in 
      African-American women with diabetes mellitus.
PG  - 104317
LID - S0195-6663(18)31855-5 [pii]
LID - 10.1016/j.appet.2019.104317 [doi]
AB  - Food addiction (FA) describes a group of disordered eating behaviors. Childhood 
      trauma has been associated with adult FA and trauma has known effects on the 
      endocrine system, but it is unclear whether FA is associated with insulin 
      resistance. We hypothesized that severity of childhood trauma will be associated 
      with FA and higher insulin resistance (HOMA-IR) in a sample of obese women with 
      type 2 diabetes mellitus (T2DM), and that FA will mediate the association between 
      childhood trauma and HOMA-IR. Women with a diagnosis of T2DM (N = 73; 
      M(BMI) = 35.86, SD(BMI) = 7.72; M(age) = 50.59, SD(age) = 9.72) were recruited 
      from a diabetes clinic at a county hospital. Participants completed the Childhood 
      Trauma Questionnaire and the Yale Food Addiction Scale. Fasting blood samples 
      were obtained from 64 participants to assess plasma hemoglobin A1c (HbA1c), 
      insulin and glucose (used to calculate HOMA-IR); Oral Glucose Tolerance Test 
      (OGTT) was performed to measure change in glucose and insulin secretion. 48% of 
      the sample met diagnostic criteria for FA. Women with FA reported significantly 
      higher HOMA-IR (F = 25.692, p < 0.001, df = 1,62), HbA1c (F = 4.358, p = 0.041, 
      df = 1,62), and OGGT glucose (F = 5.539, p = 0.022, df = 1,62) as well as 
      severity of childhood trauma (F = 10.453, p = 0.002, df = 1,71). In a 
      hierarchical linear regression controlling for BMI, income level, and T2DM 
      treatment, the severity of childhood trauma did not contribute to the prediction 
      of HOMA-IR (beta = -0.011, p = 0.942) whereas FA did (beta = 0.422, p = 0.007). In a 
      bootstrapped mediation analysis, the association between childhood trauma and 
      HOMA-IR was mediated by FA severity (b = 0.596, p = 0.020). Understanding the 
      psychological factors that contribute to HOMA-IR in an underserved population of 
      African American women may lead to more effective diabetes management and 
      prevention strategies.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Stojek, Monika M
AU  - Stojek MM
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, Atlanta, GA, USA; Emory Healthcare Veterans Program, USA.
FAU - Maples-Keller, Jessica L
AU  - Maples-Keller JL
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, Atlanta, GA, USA; Emory Healthcare Veterans Program, USA.
FAU - Dixon, Hayley Drew
AU  - Dixon HD
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, Atlanta, GA, USA.
FAU - Umpierrez, Guillermo E
AU  - Umpierrez GE
AD  - Department of Medicine, Division of Endocrinology, Emory University School of 
      Medicine, USA.
FAU - Gillespie, Charles F
AU  - Gillespie CF
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, Atlanta, GA, USA.
FAU - Michopoulos, Vasiliki
AU  - Michopoulos V
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, Atlanta, GA, USA; Yerkes National Primate Research Center, Atlanta, GA, 
      USA. Electronic address: vmichop@emory.edu.
LA  - eng
GR  - R38 AI140299/AI/NIAID NIH HHS/United States
GR  - M01 RR000039/RR/NCRR NIH HHS/United States
GR  - R01 MH099211/MH/NIMH NIH HHS/United States
GR  - UL1 RR025008/RR/NCRR NIH HHS/United States
GR  - K12 HD085850/HD/NICHD NIH HHS/United States
GR  - U54 AG062334/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190608
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Adult
MH  - *Adverse Childhood Experiences
MH  - Black or African American
MH  - Child
MH  - *Child Abuse
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Food Addiction/*psychology
MH  - Humans
MH  - *Insulin Resistance
MH  - Middle Aged
MH  - Obesity
PMC - PMC6629477
MID - NIHMS1531796
OTO - NOTNLM
OT  - Childhood abuse
OT  - Childhood trauma
OT  - Diabetes
OT  - Disordered eating
OT  - Food addiction
OT  - Insulin resistance
COIS- Declaration of interest: None
EDAT- 2019/06/12 06:00
MHDA- 2020/03/07 06:00
PMCR- 2020/10/01
CRDT- 2019/06/12 06:00
PHST- 2018/12/24 00:00 [received]
PHST- 2019/06/05 00:00 [revised]
PHST- 2019/06/07 00:00 [accepted]
PHST- 2019/06/12 06:00 [pubmed]
PHST- 2020/03/07 06:00 [medline]
PHST- 2019/06/12 06:00 [entrez]
PHST- 2020/10/01 00:00 [pmc-release]
AID - S0195-6663(18)31855-5 [pii]
AID - 10.1016/j.appet.2019.104317 [doi]
PST - ppublish
SO  - Appetite. 2019 Oct 1;141:104317. doi: 10.1016/j.appet.2019.104317. Epub 2019 Jun 
      8.