PMID- 31186474
OWN - NLM
STAT- MEDLINE
DCOM- 20201015
LR  - 20210109
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Jun 11
TI  - Ganglioside GQ1b ameliorates cognitive impairments in an Alzheimer's disease 
      mouse model, and causes reduction of amyloid precursor protein.
PG  - 8512
LID - 10.1038/s41598-019-44739-6 [doi]
LID - 8512
AB  - Brain-derived neurotrophic factor (BDNF) plays crucial roles in memory 
      impairments including Alzheimer's disease (AD). Previous studies have reported 
      that tetrasialoganglioside GQ1b is involved in long-term potentiation and 
      cognitive functions as well as BDNF expression. However, in vitro and in vivo 
      functions of GQ1b against AD has not investigated yet. Consequently, treatment of 
      oligomeric Abeta followed by GQ1b significantly restores Abeta(1-42)-induced cell death 
      through BDNF up-regulation in primary cortical neurons. Bilateral infusion of 
      GQ1b into the hippocampus ameliorates cognitive deficits in the triple-transgenic 
      AD mouse model (3xTg-AD). GQ1b-infused 3xTg-AD mice had substantially increased 
      BDNF levels compared with artificial cerebrospinal fluid (aCSF)-treated 3xTg-AD 
      mice. Interestingly, we also found that GQ1b administration into hippocampus of 
      3xTg-AD mice reduces Abeta plaque deposition and tau phosphorylation, which 
      correlate with APP protein reduction and phospho-GSK3beta level increase, 
      respectively. These findings demonstrate that the tetrasialoganglioside GQ1b may 
      contribute to a potential strategy of AD treatment.
FAU - Shin, Min-Kyoo
AU  - Shin MK
AD  - Department of Biological Sciences, Sungkyunkwan University, 2066, Seobu-ro, 
      Jangan-gu, Suwon-si, Gyeonggi-do, 16419, Republic of Korea.
FAU - Choi, Min-Suk
AU  - Choi MS
AD  - Center for Convergent Research of Emerging Virus Infection, Korea Research 
      Institute of Chemical Technology, 141, Gajeong-ro, Yuseong-gu, Daejeon, 34114, 
      Republic of Korea.
FAU - Chae, Hyang-Ji
AU  - Chae HJ
AD  - Department of Biological Sciences, Sungkyunkwan University, 2066, Seobu-ro, 
      Jangan-gu, Suwon-si, Gyeonggi-do, 16419, Republic of Korea.
FAU - Kim, Ji-Won
AU  - Kim JW
AD  - Department of Biological Sciences, Sungkyunkwan University, 2066, Seobu-ro, 
      Jangan-gu, Suwon-si, Gyeonggi-do, 16419, Republic of Korea.
FAU - Kim, Hong-Gi
AU  - Kim HG
AD  - Center for Convergent Research of Emerging Virus Infection, Korea Research 
      Institute of Chemical Technology, 141, Gajeong-ro, Yuseong-gu, Daejeon, 34114, 
      Republic of Korea. tenork@krict.re.kr.
FAU - Kim, Kil-Lyong
AU  - Kim KL
AD  - Department of Biological Sciences, Sungkyunkwan University, 2066, Seobu-ro, 
      Jangan-gu, Suwon-si, Gyeonggi-do, 16419, Republic of Korea. kimkl@skku.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190611
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gangliosides)
RN  - 0 (tau Proteins)
RN  - 68652-37-9 (GQ1b ganglioside)
SB  - IM
MH  - Alzheimer Disease/*complications/*drug therapy
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cells, Cultured
MH  - Cognitive Dysfunction/*complications/*drug therapy
MH  - Disease Models, Animal
MH  - Gangliosides/administration & dosage/pharmacology/*therapeutic use
MH  - Hippocampus/drug effects/pathology
MH  - Mice, Transgenic
MH  - Neurons/drug effects/metabolism
MH  - Rats
MH  - Up-Regulation
MH  - tau Proteins/metabolism
PMC - PMC6560179
COIS- The authors declare no competing interests.
EDAT- 2019/06/13 06:00
MHDA- 2020/10/21 06:00
PMCR- 2019/06/11
CRDT- 2019/06/13 06:00
PHST- 2018/01/23 00:00 [received]
PHST- 2019/05/20 00:00 [accepted]
PHST- 2019/06/13 06:00 [entrez]
PHST- 2019/06/13 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/06/11 00:00 [pmc-release]
AID - 10.1038/s41598-019-44739-6 [pii]
AID - 44739 [pii]
AID - 10.1038/s41598-019-44739-6 [doi]
PST - epublish
SO  - Sci Rep. 2019 Jun 11;9(1):8512. doi: 10.1038/s41598-019-44739-6.