PMID- 31186795
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 17
IP  - 6
DP  - 2019 Jun
TI  - Epithelial cell transforming sequence 2 expression is associated with the 
      progression of laryngeal squamous cell carcinoma.
PG  - 5699-5704
LID - 10.3892/ol.2019.10226 [doi]
AB  - Epithelial cell transforming sequence 2 (ECT2) is a guanine nucleotide exchange 
      factor and its expression is associated with the development of malignant tumor 
      types. However, to the best of our knowledge, there is no information on the role 
      of ECT2 in the development and progression of laryngeal squamous cell carcinoma 
      (LSCC). The present study aimed at investigating the expression pattern and 
      potential role of ECT2 in the development and progression of LSCC. The expression 
      of ECT2 in 81 pairs of LSCC and adjacent non-tumor tissues was characterized by 
      immunohistochemistry and reverse transcription-quantitative polymerase chain 
      reaction. ECT2 expression was upregulated in LSCC tissues and associated 
      significantly with poor differentiation, higher stages, lymph node metastasis and 
      poor survival in the sample population. The relative expression levels of ECT2 
      mRNA transcripts were correlated with the intensity of anti-ECT2 staining in 25 
      ECT2+LSCC specimens selected randomly. These results indicated that ECT2 
      expression was crucial for the progression of LSCC and may serve as a biomarker 
      for the diagnosis and prognosis of LSCC.
FAU - Zhu, Lin
AU  - Zhu L
AD  - Department of Otolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
AD  - Department of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
FAU - Qin, Gang
AU  - Qin G
AD  - Department of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
FAU - Ye, Lin
AU  - Ye L
AD  - Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Chongqing 
      Medical University, Chongqing 400016, P.R. China.
FAU - Jiang, Li-Zhu
AU  - Jiang LZ
AD  - Department of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of 
      Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
FAU - Zhou, Tie-Jun
AU  - Zhou TJ
AD  - Department of Pathology, The Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan 646000, P.R. China.
FAU - Luo, Bo
AU  - Luo B
AD  - Department of Biochemistry, Institute for Cancer Research, School of Preclinical 
      Medical Sciences, Southwest Medical University, Luzhou, Sichuan 646000, P.R. 
      China.
FAU - Wen, Tao-Yu
AU  - Wen TY
AD  - Department of Otolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
FAU - Liu, Ya-Lan
AU  - Liu YL
AD  - Department of Otolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
FAU - Chen, Hong-Yan
AU  - Chen HY
AD  - Department of Otolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190408
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6507463
OTO - NOTNLM
OT  - epithelial cell transforming sequence 2
OT  - immunohistochemistry
OT  - laryngeal squamous cell carcinoma
OT  - poor survival
OT  - reverse transcription-quantitative polymerase chain reaction
EDAT- 2019/06/13 06:00
MHDA- 2019/06/13 06:01
PMCR- 2019/04/08
CRDT- 2019/06/13 06:00
PHST- 2018/09/03 00:00 [received]
PHST- 2019/02/25 00:00 [accepted]
PHST- 2019/06/13 06:00 [entrez]
PHST- 2019/06/13 06:00 [pubmed]
PHST- 2019/06/13 06:01 [medline]
PHST- 2019/04/08 00:00 [pmc-release]
AID - OL-0-0-10226 [pii]
AID - 10.3892/ol.2019.10226 [doi]
PST - ppublish
SO  - Oncol Lett. 2019 Jun;17(6):5699-5704. doi: 10.3892/ol.2019.10226. Epub 2019 Apr 
      8.