PMID- 31189152
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1523-7834 (Print)
IS  - 1523-7834 (Linking)
VI  - 45
IP  - 2
DP  - 2019
TI  - Transient Abnormal Myelopoiesis: A Clue to Trisomy 21.
PG  - 77-79
AB  - Interphase fluorescence in situ hybridization (FISH) cutoff values are calculated 
      using various mathematical methods to determine whether abnormalities seen are at 
      reportable (statistically significant) levels. However, for interphase FISH 
      studies of samples obtained from oncology patients who have been transplanted or 
      treated, these cutoff values may result in reporting a false negative result due 
      to the small percentage of residual disease that falls below such a cutoff value. 
      Failure to detect the rare abnormal cells may impact patient care and prognosis. 
      For such situations, the two questions are: is the disease still present, and if 
      so, how prevalent is it? The first question is qualitative and the second is 
      quantitative. Traditionally, only the quantitative parameters have been used for 
      determining reportability. Here we propose a method to account for both 
      qualitative and quantitative evaluations of interphase FISH results.
CI  - Copyright(c) by the Association of Genetic Technologists.
FAU - Wilcock, Jonathan
AU  - Wilcock J
AD  - Department of Pathology and Laboratory Medicine, University of Vermont Medical 
      Center, Burlington, VT.
FAU - Devitt, Katherine
AU  - Devitt K
AD  - Department of Pathology and Laboratory Medicine, University of Vermont Medical 
      Center, Burlington, VT.
FAU - Gardner, Juli-Anne
AU  - Gardner JA
AD  - Department of Pathology and Laboratory Medicine, University of Vermont Medical 
      Center, Burlington, VT.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Assoc Genet Technol
JT  - Journal of the Association of Genetic Technologists
JID - 9807282
EDAT- 2019/06/13 06:00
MHDA- 2019/06/13 06:01
CRDT- 2019/06/13 06:00
PHST- 2018/09/10 00:00 [received]
PHST- 2019/06/02 00:00 [accepted]
PHST- 2019/06/13 06:00 [entrez]
PHST- 2019/06/13 06:00 [pubmed]
PHST- 2019/06/13 06:01 [medline]
PST - ppublish
SO  - J Assoc Genet Technol. 2019;45(2):77-79.