PMID- 3118930
OWN - NLM
STAT- MEDLINE
DCOM- 19880105
LR  - 20190704
IS  - 0007-0963 (Print)
IS  - 0007-0963 (Linking)
VI  - 117
IP  - 3
DP  - 1987 Sep
TI  - Relationship between circulating anti-Ro/SS-A antibody levels and skin disease 
      activity in subacute cutaneous lupus erythematosus.
PG  - 277-87
AB  - Anti-Ro/SS-A antibody levels in 80 serum specimens from 12 patients with subacute 
      cutaneous lupus erythematosus (SCLE) were determined by immunodiffusion and 
      enzyme-linked immunosorbent assay in order to examine the changes in this 
      autoantibody response with time and to study the relationship between levels of 
      this antibody and SCLE skin disease activity. Anti-Ro/SS-A antibody levels were 
      found to vary considerably over time in a given patient when measured by both 
      assays. Several patients who did not have detectable levels of this antibody at 
      the time of their initial examination were found to be antibody positive at 
      follow-up examinations. However, no significant relationship was found between 
      antibody levels in either assay and SCLE skin disease activity. While not ruling 
      out a pathogenetic role for this antibody in the elicitation of SCLE skin 
      lesions, these results would suggest that other factors are likely to be 
      involved.
FAU - Purcell, S M
AU  - Purcell SM
AD  - Department of Dermatology, University of Texas Health Science Center, 
      Southwestern Medical School, Dallas 75235.
FAU - Lieu, T S
AU  - Lieu TS
FAU - Davis, B M
AU  - Davis BM
FAU - Sontheimer, R D
AU  - Sontheimer RD
LA  - eng
GR  - AM-19101/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoantibodies/*analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunodiffusion
MH  - Lupus Erythematosus, Cutaneous/drug therapy/*immunology
MH  - Male
MH  - Middle Aged
EDAT- 1987/09/01 00:00
MHDA- 1987/09/01 00:01
CRDT- 1987/09/01 00:00
PHST- 1987/09/01 00:00 [pubmed]
PHST- 1987/09/01 00:01 [medline]
PHST- 1987/09/01 00:00 [entrez]
AID - 10.1111/j.1365-2133.1987.tb04133.x [doi]
PST - ppublish
SO  - Br J Dermatol. 1987 Sep;117(3):277-87. doi: 10.1111/j.1365-2133.1987.tb04133.x.