PMID- 31191428
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 10
DP  - 2019
TI  - Efficacy of LVIS vs. Enterprise Stent for Endovascular Treatment of Medium-Sized 
      Intracranial Aneurysms: A Hemodynamic Comparison Study.
PG  - 522
LID - 10.3389/fneur.2019.00522 [doi]
LID - 522
AB  - Background: We conducted a computational fluid dynamics (CFD) study and compared 
      the treatment of medium-sized intracranial aneurysms with LVIS and Enterprise 
      stent-assisted coil embolization (SACE) to determine the effects of hemodynamic 
      changes caused by different stent and coil packing densities (PDs) in 
      endovascular treatment. Methods: We enrolled 87 consecutive patients, with 87 
      medium-sized intracranial aneurysms (>/=7, </= 12 mm), who underwent LVIS or 
      Enterprise SACE. Aneurysms treated with LVIS SACE were allocated to the LVIS 
      group, and the remainder were allocated to the Enterprise group. CFD were 
      performed to assess hemodynamic alterations between before treatment, after stent 
      deployment, and after SACE. Results: One aneurysm recanalized in the LVIS group 
      (n = 42), and five recanalized in the Enterprise group (n = 45) (recanalization 
      rate: 2.4 vs. 11.1%, respectively; P = 0.108). Higher complete obliteration rate 
      (P = 0.069) was found in the LVIS group. Velocity at the neck plane showed a 
      greater reduction ratio than velocity and WSS of the aneurysm in both groups 
      after stent deployment, while velocity and WSS of the aneurysm showed a greater 
      reduction ratio after coil placement. Further, there was a greater reduction in 
      velocity at the neck plane (59.52 vs. 39.81%), aneurysmal velocity (88.46 vs. 
      69.45%), and wall shear stress (WSS) (85.45 vs. 69.49%) on the aneurysm in the 
      LVIS group (P < 0.001 for all). Specifically, the reduction ratio of velocity at 
      the neck plane showed significant difference between the groups in the 
      multivariate analysis (P = 0.013). Conclusions : LVIS SACE showed a lower 
      recanalization for endovascular treatment of medium-sized intracranial aneurysms, 
      and the greater hemodynamic alterations might be the key factors.
FAU - Li, Wenqiang
AU  - Li W
AD  - Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and 
      Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
FAU - Wang, Yang
AU  - Wang Y
AD  - Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, 
      Nanchang University, Nanchang, China.
FAU - Zhang, Yisen
AU  - Zhang Y
AD  - Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and 
      Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
FAU - Wang, Kun
AU  - Wang K
AD  - Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and 
      Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and 
      Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
FAU - Tian, Zhongbin
AU  - Tian Z
AD  - Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and 
      Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
FAU - Yang, Xinjian
AU  - Yang X
AD  - Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and 
      Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
FAU - Liu, Jian
AU  - Liu J
AD  - Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and 
      Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20190528
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC6546800
OTO - NOTNLM
OT  - computational fluid dynamics
OT  - endovascular treatment
OT  - hemodynamics
OT  - intracranial aneurysms
OT  - stent
EDAT- 2019/06/14 06:00
MHDA- 2019/06/14 06:01
PMCR- 2019/05/28
CRDT- 2019/06/14 06:00
PHST- 2019/02/27 00:00 [received]
PHST- 2019/05/01 00:00 [accepted]
PHST- 2019/06/14 06:00 [entrez]
PHST- 2019/06/14 06:00 [pubmed]
PHST- 2019/06/14 06:01 [medline]
PHST- 2019/05/28 00:00 [pmc-release]
AID - 10.3389/fneur.2019.00522 [doi]
PST - epublish
SO  - Front Neurol. 2019 May 28;10:522. doi: 10.3389/fneur.2019.00522. eCollection 
      2019.