PMID- 31191558
OWN - NLM
STAT- MEDLINE
DCOM- 20200616
LR  - 20200616
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development 
      and Heterogeneity.
PG  - 1222
LID - 10.3389/fimmu.2019.01222 [doi]
LID - 1222
AB  - Dendritic cells (DCs) are professional antigen presenting cells (APCs) that 
      originate in the bone marrow and are continuously replenished from hematopoietic 
      progenitor cells. Conventional DCs (cDCs) and plasmacytoid DCs (pDCs) are 
      distinguished by morphology and function, and can be easily discriminated by 
      surface marker expression, both in mouse and man. Classification of DCs based on 
      their ontology takes into account their origin as well as their requirements for 
      transcription factor (TF) expression. cDCs and pDCs of myeloid origin 
      differentiate from a common DC progenitor (CDP) through committed pre-DC stages. 
      pDCs have also been shown to originate from a lymphoid progenitor derived 
      IL-7R(+) FLT3(+) precursor population containing cells with pDC or B cell 
      potential. Technological advancements in recent years have allowed unprecedented 
      resolution in the analysis of cell states, down to the single cell level, 
      providing valuable information on the commitment, and dynamics of differentiation 
      of all DC subsets. However, the heterogeneity and functional diversification of 
      pDCs still raises the question whether different ontogenies generate restricted 
      pDC subsets, or fully differentiated pDCs retain plasticity in response to 
      challenges. The emergence of novel techniques for the integration of 
      high-resolution data in individual cells promises interesting discoveries 
      regarding DC development and plasticity in the near future.
FAU - Musumeci, Andrea
AU  - Musumeci A
AD  - Institute for Immunology, Biomedical Center, Ludwig-Maximilian-University, 
      Munich, Germany.
FAU - Lutz, Konstantin
AU  - Lutz K
AD  - Institute for Immunology, Biomedical Center, Ludwig-Maximilian-University, 
      Munich, Germany.
FAU - Winheim, Elena
AU  - Winheim E
AD  - Institute for Immunology, Biomedical Center, Ludwig-Maximilian-University, 
      Munich, Germany.
FAU - Krug, Anne Barbara
AU  - Krug AB
AD  - Institute for Immunology, Biomedical Center, Ludwig-Maximilian-University, 
      Munich, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190529
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Animals
MH  - Cell Differentiation/immunology
MH  - Cell Plasticity/immunology
MH  - Computational Biology
MH  - Dendritic Cells/cytology/*immunology/*metabolism
MH  - Humans
MH  - Lymphoid Progenitor Cells/cytology/metabolism
MH  - Lymphoid Tissue/cytology/immunology/metabolism
MH  - Myeloid Progenitor Cells/cytology/metabolism
MH  - Signal Transduction
PMC - PMC6548821
OTO - NOTNLM
OT  - DC progenitor
OT  - dendritic cell development
OT  - hematopoiesis
OT  - heterogeneity
OT  - plasmacytoid dendritic cells
OT  - plasticity
EDAT- 2019/06/14 06:00
MHDA- 2020/06/17 06:00
PMCR- 2019/01/01
CRDT- 2019/06/14 06:00
PHST- 2018/10/04 00:00 [received]
PHST- 2019/05/13 00:00 [accepted]
PHST- 2019/06/14 06:00 [entrez]
PHST- 2019/06/14 06:00 [pubmed]
PHST- 2020/06/17 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.01222 [doi]
PST - epublish
SO  - Front Immunol. 2019 May 29;10:1222. doi: 10.3389/fimmu.2019.01222. eCollection 
      2019.