PMID- 31193510
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231011
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 5
IP  - 5
DP  - 2019 May
TI  - Synthesis and characterization of Zn-Doped hydroxyapatite: scaffold application, 
      antibacterial and bioactivity studies.
PG  - e01716
LID - 10.1016/j.heliyon.2019.e01716 [doi]
LID - e01716
AB  - In this study, the antimicrobial and scaffold of zinc-substituted hydroxyapatite, 
      (Zn-HAp) synthesized via chemical co-precipitation technique was investigated. 
      The structure of the synthesized Zn-HAp was investigated with X-ray diffraction 
      (XRD), Fourier transform infrared (FT-IR) spectroscopy, Scanning electron 
      microscope (SEM), Energy dispersive X-spectroscopy (EDAX), transmission electron 
      microscope (TEM), Thermogravimetric analysis (TGA) and X-ray photoelectron 
      spectroscopy (XPS). Bioactivity study was performed in simulated body fluid 
      (SBF), while the antimicrobial activity was studied using disc diffusion method. 
      The XRD structure revealed that Zn ion incorporation up to 10% led to the second 
      phase hydroxyapatite (HAp) formation, while higher concentration diminished the 
      apatite structure. The presence of phosphate ions, carbonates ions, and hydroxyl 
      groups in the apatite powder was ascertained by the FT-IR evaluation. SEM 
      evaluation showed that the apatite contains fine particles with nearly round 
      shape with interconnected pores and decreasing Ca/P ratio with increasing Zn ion 
      concentration. TEM results showed particulate polycrystalline apatite with 
      crystallite size ranging from 68 nm in pure HAp to 41 nm in 20% Zn-doped HAp 
      indicating a decrease in the crystal size with increasing Zn ion in the samples. 
      The bioactivity study showed spherical deposition around the porous region of the 
      scaffold HAp suggesting the growth of apatite in SBF media after 7 days of 
      incubation, while antibacterial activity studies showed zones of inhibition with 
      an increase in zinc ions concentrations.
FAU - Ofudje, Edwin Andrew
AU  - Ofudje EA
AD  - Department of Chemical Sciences, Mountain Top University, Ibafo, Nigeria.
AD  - Department of Chemistry, Federal University of Agriculture, Abeokuta, Nigeria.
FAU - Adeogun, Abideen Idowu
AU  - Adeogun AI
AD  - Department of Chemistry, Federal University of Agriculture, Abeokuta, Nigeria.
FAU - Idowu, Mopelola Abidemi
AU  - Idowu MA
AD  - Department of Chemistry, Federal University of Agriculture, Abeokuta, Nigeria.
FAU - Kareem, Sarafadeen Olateju
AU  - Kareem SO
AD  - Department of Microbiology, Federal University of Agriculture, Abeokuta, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20190521
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC6531666
OTO - NOTNLM
OT  - Materials chemistry
OT  - Materials science
EDAT- 2019/06/14 06:00
MHDA- 2019/06/14 06:01
PMCR- 2019/05/21
CRDT- 2019/06/14 06:00
PHST- 2018/12/11 00:00 [received]
PHST- 2019/04/16 00:00 [revised]
PHST- 2019/05/09 00:00 [accepted]
PHST- 2019/06/14 06:00 [entrez]
PHST- 2019/06/14 06:00 [pubmed]
PHST- 2019/06/14 06:01 [medline]
PHST- 2019/05/21 00:00 [pmc-release]
AID - S2405-8440(18)38693-6 [pii]
AID - e01716 [pii]
AID - 10.1016/j.heliyon.2019.e01716 [doi]
PST - epublish
SO  - Heliyon. 2019 May 21;5(5):e01716. doi: 10.1016/j.heliyon.2019.e01716. eCollection 
      2019 May.