PMID- 31193545
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2352-2895 (Print)
IS  - 2352-2895 (Electronic)
IS  - 2352-2895 (Linking)
VI  - 10
DP  - 2019 Feb
TI  - Effects of restraint stress on the regulation of hippocampal glutamate receptor 
      and inflammation genes in female C57BL/6 and BALB/c mice.
PG  - 100169
LID - 10.1016/j.ynstr.2019.100169 [doi]
LID - 100169
AB  - The two strains of inbred mice, BALB/c and C57BL/6, are widely used in 
      pre-clinical psychiatry research due to their differences in stress 
      susceptibility. Gene profiling studies in these strains have implicated the 
      inflammation pathway as the main contributor to these differences. We focused our 
      attention on female mice and tested their response to 5- or 10-day exposure to 
      restraint stress. We examined the stress induced changes in the regulation of 11 
      inflammatory cytokine genes and 12 glutamate receptor genes in the hippocampus of 
      female BALB/c and C57BL/6 mice using quantitative PCR. Elevated proinflammatory 
      cytokine genes include Tumor Necrosis Factor alpha (TNFa), nuclear factor 
      kappa-light-chain-enhancer of activated B cells (NFKB), Interleukin 1 alpha 
      (IL1a), Interleukin 1 receptor (IL1R), Interleukin 10 receptor alpha subunit 
      (IL10Ra), Interleukin 10 receptor beta subunit (IL10Rb), and tumor necrosis 
      factor (TNF) super family members. Our results show that BALB/c and C57BL/6 mice 
      differ in the genes induced in response to stress exposure and the level of gene 
      regulation change. Our results show that the gene regulation in female BALB/c and 
      C57BL/6 mice differs between strains in the genes regulated and the magnitude of 
      the changes.
FAU - McWhirt, Joshua
AU  - McWhirt J
AD  - Division of Basic Biomedical Sciences, University of South Dakota, Vermillion, 
      SD, 57069, USA.
FAU - Sathyanesan, Monica
AU  - Sathyanesan M
AD  - Division of Basic Biomedical Sciences, Sanford School of Medicine, University of 
      South Dakota, Vermillion, SD 57069, Sioux Falls VA Healthcare System, Sioux 
      Falls, SD, 57105, USA.
FAU - Sampath, Dayalan
AU  - Sampath D
AD  - Division of Basic Biomedical Sciences, Sanford School of Medicine, University of 
      South Dakota, Vermillion, SD, 57069, USA.
FAU - Newton, Samuel S
AU  - Newton SS
AD  - Division of Basic Biomedical Sciences, Sanford School of Medicine, University of 
      South Dakota, Vermillion, SD 57069, Sioux Falls VA Healthcare System, Sioux 
      Falls, SD, 57105, USA.
LA  - eng
GR  - R01 MH106640/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20190430
PL  - United States
TA  - Neurobiol Stress
JT  - Neurobiology of stress
JID - 101643409
PMC - PMC6535649
OTO - NOTNLM
OT  - Female
OT  - Gene expression
OT  - Glutamate receptors
OT  - Hippocampus
OT  - Proinflammatory genes
OT  - Restraint stress
EDAT- 2019/06/14 06:00
MHDA- 2019/06/14 06:01
PMCR- 2019/04/30
CRDT- 2019/06/14 06:00
PHST- 2019/01/10 00:00 [received]
PHST- 2019/04/10 00:00 [revised]
PHST- 2019/04/30 00:00 [accepted]
PHST- 2019/06/14 06:00 [entrez]
PHST- 2019/06/14 06:00 [pubmed]
PHST- 2019/06/14 06:01 [medline]
PHST- 2019/04/30 00:00 [pmc-release]
AID - S2352-2895(19)30004-9 [pii]
AID - 100169 [pii]
AID - 10.1016/j.ynstr.2019.100169 [doi]
PST - epublish
SO  - Neurobiol Stress. 2019 Apr 30;10:100169. doi: 10.1016/j.ynstr.2019.100169. 
      eCollection 2019 Feb.