PMID- 31193989
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2352-3409 (Electronic)
IS  - 2352-3409 (Linking)
VI  - 24
DP  - 2019 Jun
TI  - Data on MECOM rearrangement-driven chromosomal aberrations in myeloid 
      malignancies.
PG  - 104025
LID - 10.1016/j.dib.2019.104025 [doi]
LID - 104025
AB  - Data in this article presents the results of conventional cytogenetics and 
      fluorescence in situ hybridization (FISH) analyses in 129 patients with confirmed 
      MECOM rearrangement (https://doi.org/10.1016/j.cancergen.2019.03.002) [1]. 
      Generally, the MECOM rearrangement has arisen through translocation, inversion, 
      and insertion and/or unknown mechanism. In addition to the typical chromosomal 
      aberrations, inv(3)(q21q26.2) and t(3; 3)(q21; q26.6) [2-4], over 50% of cases 
      presented here exhibit a wide spectrum of MECOM rearrangement-driven, atypical 
      chromosomal aberrations, including inv(3) with breakpoint other than 3q21; t(1; 
      3); t(2; 3); t(3; 6); t(3; 8); t(3; 12); t(3; 17); t(3; 21) as well as an 
      insertion of 3q26.2 into different chromosomes. These cases are thoroughly 
      characterized by karyotyping, interphase-, metaphase-, map-back FISH and whole 
      chromosomal painting (WCP) analyses.
FAU - Tang, Zhenya
AU  - Tang Z
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Tang, Guilin
AU  - Tang G
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Hu, Shimin
AU  - Hu S
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Patel, Keyur P
AU  - Patel KP
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Cameron Yin, C
AU  - Cameron Yin C
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Lin, Pei
AU  - Lin P
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Toruner, Gokce A
AU  - Toruner GA
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Ok, Chi Y
AU  - Ok CY
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Gu, Jun
AU  - Gu J
AD  - Cytogenetic Technology Program, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Lu, Xinyan
AU  - Lu X
AD  - Department of Pathology, Feinberg School of Medicine, Northwestern University, 
      Chicago, IL 60611, USA.
FAU - Khoury, Joseph D
AU  - Khoury JD
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Jeffrey Medeiros, L
AU  - Jeffrey Medeiros L
AD  - Department of Hematopathology, School of Health Professions, The University of 
      Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
LA  - eng
PT  - Journal Article
DEP - 20190523
PL  - Netherlands
TA  - Data Brief
JT  - Data in brief
JID - 101654995
PMC - PMC6545385
OTO - NOTNLM
OT  - Fluorescence in situ hybridization (FISH)
OT  - Insertion
OT  - Inversion
OT  - MECOM rearrangement
OT  - Translocation
EDAT- 2019/06/14 06:00
MHDA- 2019/06/14 06:01
PMCR- 2019/05/23
CRDT- 2019/06/14 06:00
PHST- 2019/03/25 00:00 [received]
PHST- 2019/04/29 00:00 [revised]
PHST- 2019/05/13 00:00 [accepted]
PHST- 2019/06/14 06:00 [entrez]
PHST- 2019/06/14 06:00 [pubmed]
PHST- 2019/06/14 06:01 [medline]
PHST- 2019/05/23 00:00 [pmc-release]
AID - S2352-3409(19)30378-6 [pii]
AID - 104025 [pii]
AID - 10.1016/j.dib.2019.104025 [doi]
PST - epublish
SO  - Data Brief. 2019 May 23;24:104025. doi: 10.1016/j.dib.2019.104025. eCollection 
      2019 Jun.