PMID- 31195041
OWN - NLM
STAT- MEDLINE
DCOM- 20191231
LR  - 20191231
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 136
DP  - 2019 Sep 1
TI  - Regulation of lipid metabolism in diabetic rats by Arctium lappa L. 
      polysaccharide through the PKC/NF-kappaB pathway.
PG  - 115-122
LID - S0141-8130(19)32626-1 [pii]
LID - 10.1016/j.ijbiomac.2019.06.057 [doi]
AB  - Diabetic patients often have lipid metabolism disorders, which can lead to 
      life-threatening complications. In this study, we investigated the regulatory 
      effects of polysaccharides extracted from Arctium lappa L. on lipid metabolism in 
      diabetic rats. We constructed a diabetes mellitus mouse model with streptozocin, 
      and treated the rats with A. lappa L. polysaccharide. The body weight analysis 
      showed that the weight of diabetic rats significantly decreased, but the weight 
      of the rats in the polysaccharide treatment groups increased and the ratio of 
      liver weight to body weight also appeared the well effect (tending to normal 
      group). Serum biochemical analysis showed that total cholesterol (TC), 
      triglyceride (TG), low-density lipoprotein cholesterol (LDL), and the ratio of 
      liver weight to body weight showed a downward trend. In addition, compared to 
      TC/HDL, TG/HDL, and HDL/LDL, the relative content of HDL was increased. 
      Meanwhile, we used Western blotting to detect changes in protein kinase C alpha 
      (PKC-alpha), PKC-beta, P-selectin, nuclear factor kappa B (NF-kappaB), and phosphorylated 
      NF-kB p65 in the liver. The results showed that the A. lappa L. polysaccharides 
      regulated lipid metabolism through the PKC/NF-kappaB pathway in diabetic rats.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Li, Xinpeng
AU  - Li X
AD  - Linyi University College of Pharmacy, Linyi, Shandong, China.
FAU - Zhao, Zhilong
AU  - Zhao Z
AD  - Linyi University College of Pharmacy, Linyi, Shandong, China.
FAU - Kuang, Pengqun
AU  - Kuang P
AD  - Linyi University College of Pharmacy, Linyi, Shandong, China.
FAU - Shi, Xiaowei
AU  - Shi X
AD  - Linyi University College of Pharmacy, Linyi, Shandong, China.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Linyi University College of Pharmacy, Linyi, Shandong, China; National Resources 
      Center of Chinese Material Medica, China Academy of Chinese Medical Sciences, 
      China. Electronic address: wangzhen@lyu.edu.cn.
FAU - Guo, Lanping
AU  - Guo L
AD  - National Resources Center of Chinese Material Medica, China Academy of Chinese 
      Medical Sciences, China.
LA  - eng
PT  - Journal Article
DEP - 20190610
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (NF-kappa B)
RN  - 0 (Polysaccharides)
RN  - EC 2.7.11.13 (Protein Kinase C)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Arctium/*chemistry
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects
MH  - Diabetes Mellitus, Experimental/blood/*metabolism/pathology
MH  - Lipid Metabolism/*drug effects
MH  - Liver/drug effects/metabolism/pathology
MH  - Male
MH  - NF-kappa B/*metabolism
MH  - Organ Size/drug effects
MH  - Polysaccharides/*pharmacology
MH  - Protein Kinase C/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Arctium lappa L. polysaccharide
OT  - Diabetes mellitus
OT  - Lipid metabolism
OT  - PKC/NF-kappaB
EDAT- 2019/06/14 06:00
MHDA- 2020/01/01 06:00
CRDT- 2019/06/14 06:00
PHST- 2019/04/10 00:00 [received]
PHST- 2019/06/05 00:00 [revised]
PHST- 2019/06/09 00:00 [accepted]
PHST- 2019/06/14 06:00 [pubmed]
PHST- 2020/01/01 06:00 [medline]
PHST- 2019/06/14 06:00 [entrez]
AID - S0141-8130(19)32626-1 [pii]
AID - 10.1016/j.ijbiomac.2019.06.057 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2019 Sep 1;136:115-122. doi: 10.1016/j.ijbiomac.2019.06.057. 
      Epub 2019 Jun 10.