PMID- 31195431
OWN - NLM
STAT- MEDLINE
DCOM- 20200214
LR  - 20211204
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 51
IP  - 9
DP  - 2019 Oct
TI  - The correlation between mammalian target of rapamycin (mTOR) gene expression and 
      sperm DNA damage among infertile patients with and without varicocele.
PG  - e13341
LID - 10.1111/and.13341 [doi]
AB  - This study aimed to assess the possible correlation between mammalian target of 
      rapamycin (mTOR) gene expression and sperm DNA damage among infertile patients 
      with and without varicocele. The study included sixty infertile males and fifty 
      fertile males as controls. The infertile group was subdivided into the following 
      subgroups: thirty males with varicocele and thirty males without varicocele. All 
      subjects underwent medical history collection, clinical examination, semen 
      analysis, sperm DNA integrity assessment, mTOR gene expression assessment and 
      scrotal colour Doppler ultrasound. The mean mTOR gene expression in infertile 
      patients with varicocele (23.52 +/- 14.65) was significantly higher than that in 
      infertile patients without varicocele (12.24 +/- 12.44) and fertile control 
      subjects (3.92 +/- 3.26; p = 0.003 and p < 0.001 respectively). In the infertile 
      varicocele-positive group, mTOR gene expression showed a significant negative 
      correlation with sperm count (p = 0.028, r = -0.400) and progressive sperm 
      motility (p = 0.038, r = -0.381), as well as a significant positive correlation 
      with the sperm DNA fragmentation index (DFI; p = 0.001, r = 0.578). In the 
      infertile varicocele-negative group, mTOR gene expression showed a significant 
      negative correlation with progressive sperm motility (p = 0.018, r = -0.429) and 
      a significant positive correlation with sperm DFI (p < 0.001, r = 0.673). In 
      conclusion, according to these results, there is a significant positive 
      correlation between mTOR gene expression and sperm DFI among infertile patients 
      with and without varicocele.
CI  - (c) 2019 Blackwell Verlag GmbH.
FAU - Mahran, Ali M
AU  - Mahran AM
AUID- ORCID: 0000-0001-7870-4110
AD  - Dermatology, Venereolgy and Andrology Department, Faculty of Medicine, Assiut 
      University, Assiut, Egypt.
FAU - Mosad, Eman
AU  - Mosad E
AD  - Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, 
      Assiut, Egypt.
FAU - Abdel-Raheem, Mohamed A
AU  - Abdel-Raheem MA
AD  - Dermatology and Andrology Department, Police Hospital, Assiut, Egypt.
FAU - Ahmed, Eman H
AU  - Ahmed EH
AD  - Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, 
      Assiut, Egypt.
FAU - Abdel Motaleb, Amira Ali
AU  - Abdel Motaleb AA
AUID- ORCID: 0000-0001-9905-7119
AD  - Dermatology, Venereolgy and Andrology Department, Faculty of Medicine, Assiut 
      University, Assiut, Egypt.
FAU - Hofny, Eman R
AU  - Hofny ER
AD  - Dermatology, Venereolgy and Andrology Department, Faculty of Medicine, Assiut 
      University, Assiut, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190613
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - *DNA Fragmentation
MH  - Humans
MH  - Infertility, Male/etiology/*pathology
MH  - Male
MH  - Scrotum/blood supply/diagnostic imaging
MH  - Semen Analysis
MH  - Spermatozoa/*pathology
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Ultrasonography, Doppler, Color
MH  - Varicocele/complications/diagnosis/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - DNA
OT  - mTOR
OT  - varicocele
EDAT- 2019/06/14 06:00
MHDA- 2020/02/15 06:00
CRDT- 2019/06/14 06:00
PHST- 2018/12/31 00:00 [received]
PHST- 2019/05/08 00:00 [revised]
PHST- 2019/05/11 00:00 [accepted]
PHST- 2019/06/14 06:00 [pubmed]
PHST- 2020/02/15 06:00 [medline]
PHST- 2019/06/14 06:00 [entrez]
AID - 10.1111/and.13341 [doi]
PST - ppublish
SO  - Andrologia. 2019 Oct;51(9):e13341. doi: 10.1111/and.13341. Epub 2019 Jun 13.