PMID- 31196101 OWN - NLM STAT- MEDLINE DCOM- 20200316 LR - 20200316 IS - 1476-069X (Electronic) IS - 1476-069X (Linking) VI - 18 IP - 1 DP - 2019 Jun 13 TI - Prenatal plasma concentrations of Perfluoroalkyl and polyfluoroalkyl substances and neuropsychological development in children at four years of age. PG - 53 LID - 10.1186/s12940-019-0493-3 [doi] LID - 53 AB - OBJECTIVE: Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent pollutants and have endocrine disruptive and neurotoxic effects. The association between maternal PFAS concentrations and neuropsychological development in children is inconclusive. The present study aimed to examine the effect of maternal PFAS concentrations on neuropsychological development in 4-years-old children. METHODS: We used data from Shanghai-Minhang Birth Cohort, which recruited pregnant women at 12-16 gestational weeks. Among 981 women having PFAS measurement, 533 mother-child pairs were included in the study. A total of eight PFASs were measured, including perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUdA), perfluorododecanoic acid (PFDoA), and perfluorotridecanoic acid (PFTrDA). When infants turned 4 years old, mothers were asked to complete the Ages and Stages Questionnaires(R) (ASQ) to assess neuropsychological development of their children. Poisson regression model with robust variance estimates was used to examine the association between maternal PFAS concentrations and each developmental subscale of the ASQ. RESULTS: Prenatal plasma concentrations of most PFASs tended to be associated with increased risk of development problem in personal-social skills, including PFHxS, PFOS, PFOA, PFNA, PFDA, and PDUdA, and the associations for PFNA and PFDA were significant (per natural log unit increase: RR(PFNA) = 1.92, 95% CI: 1.21, 3.05; RR (PFDA) = 1.66, 95% CI: 1.17, 2.37). In stratified analyses by child' sex, the consistent pattern of higher risk of developmental problems in personal-social skills associated with most PFASs was mainly observed among girls (RR(PFOS) = 2.56, 95% CI: 1.20, 5.45; RR(PFOA) = 9.00, 95% CI: 3.82, 21.21; RR(PFNA) = 3.11, 95% CI: 1.36, 7.13; RR(PFDA) = 2.20, 95% CI: 1.21, 4.00; RR(PFUdA) = 2.44, 95% CI: 1.14, 5.20; RR(PFDoA) = 1.62, 95% CI: 1.04, 2.54). Boys with higher maternal PFOA concentrations had a decreased risk of developmental problems in gross motor skills (RR = 0.47, 95% CI: 0.25, 0.89). CONCLUSION: Prenatal plasma PFAS concentrations were associated with neuropsychological development in girls at 4 years of age, mainly in the subset of personal-social skills. FAU - Niu, Jinbo AU - Niu J AD - The First People's Hospital of Jianshan, Jiaxing, Zhejiang Province, China. FAU - Liang, Hong AU - Liang H AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. FAU - Tian, Youping AU - Tian Y AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. FAU - Yuan, Wei AU - Yuan W AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. FAU - Xiao, Hong AU - Xiao H AD - Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, 1225 Center Drive, HPNP 3338, Gainesville, FL, 32610, USA. FAU - Hu, Hui AU - Hu H AD - Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA. FAU - Sun, Xiaowei AU - Sun X AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. FAU - Song, Xiuxia AU - Song X AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. FAU - Wen, Sheng AU - Wen S AD - National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China. FAU - Yang, Li AU - Yang L AD - Department of Public Educaion, Weifang Medical University, 7166 Baotong west Road, Weifang, 261053, Shandong Province, China. FAU - Ren, Yanfeng AU - Ren Y AD - Department of Health Statistics, School of Public Health and Management, Weifang Medical University, 7166 Baotong west Road, Weifang, 261053, Shandong Province, China. renyf1978@163.com. FAU - Miao, Maohua AU - Miao M AD - NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. LA - eng GR - 2018YFC1002801/the National Key Research and Development Program of China/International GR - 2016YFC1000505/the National Key Research and Development Program of China/International GR - 2017YFC1600500/the National Key Research and Development Program of China/International GR - 16ZR1430100/the Science and Technology Commission of Shanghai Municipality/International GR - 21628701/the National Natural Science Foundation of China/International GR - 201840184/Shanghai municipal health commission/International GR - 2018KY812/Health Commission of Zhejiang Province/International GR - 2016BY58088/Health Commission of Jiaxing City/International GR - 2016A05/Health Commission of Jiaxing City/International GR - CX2017-06/Innovation-oriented Science and Technology Grant from NHC Key Laboratory of Reproduction Regulation/International PT - Journal Article DEP - 20190613 PL - England TA - Environ Health JT - Environmental health : a global access science source JID - 101147645 RN - 0 (Endocrine Disruptors) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - Adult MH - Child, Preschool MH - Endocrine Disruptors/*adverse effects MH - Environmental Pollutants/*adverse effects MH - Female MH - Fetus/*drug effects MH - Fluorocarbons/*adverse effects MH - Humans MH - Male MH - Maternal Exposure/*adverse effects MH - *Neuropsychological Tests MH - Young Adult PMC - PMC6567504 OTO - NOTNLM OT - Age and stage questionnaire OT - Neuropsychology OT - Perfluoroalkyl and polyfluoroalkyl substances OT - Prenatal concentrations COIS- The authors declare that they have no competing interests. EDAT- 2019/06/15 06:00 MHDA- 2020/03/17 06:00 PMCR- 2019/06/13 CRDT- 2019/06/15 06:00 PHST- 2019/01/05 00:00 [received] PHST- 2019/05/31 00:00 [accepted] PHST- 2019/06/15 06:00 [entrez] PHST- 2019/06/15 06:00 [pubmed] PHST- 2020/03/17 06:00 [medline] PHST- 2019/06/13 00:00 [pmc-release] AID - 10.1186/s12940-019-0493-3 [pii] AID - 493 [pii] AID - 10.1186/s12940-019-0493-3 [doi] PST - epublish SO - Environ Health. 2019 Jun 13;18(1):53. doi: 10.1186/s12940-019-0493-3.