PMID- 31196793
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20240207
IS  - 2215-0374 (Electronic)
IS  - 2215-0366 (Print)
IS  - 2215-0366 (Linking)
VI  - 6
IP  - 7
DP  - 2019 Jul
TI  - Catatonia and the immune system: a review.
PG  - 620-630
LID - S2215-0366(19)30190-7 [pii]
LID - 10.1016/S2215-0366(19)30190-7 [doi]
AB  - Catatonia is a psychomotor disorder featuring stupor, posturing, and 
      echophenomena. This Series paper examines the evidence for immune dysregulation 
      in catatonia. Activation of the innate immune system is associated with mutism, 
      withdrawal, and psychomotor retardation, which constitute the neurovegetative 
      features of catatonia. Evidence is sparse and conflicting for acute-phase 
      activation in catatonia, and whether this feature is secondary to immobility is 
      unclear. Various viral, bacterial, and parasitic infections have been associated 
      with catatonia, but it is primarily linked to CNS infections. The most common 
      cause of autoimmune catatonia is N-methyl-D-aspartate receptor (NMDAR) 
      encephalitis, which can account for the full spectrum of catatonic features. 
      Autoimmunity appears to cause catatonia less by systemic inflammation than by the 
      downstream effects of specific actions on extracellular antigens. The specific 
      association with NMDAR encephalitis supports a hypothesis of glutamatergic 
      hypofunction in catatonia.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Rogers, Jonathan P
AU  - Rogers JP
AD  - Department of Psychosis Studies, Institute of Psychiatry, Psychology and 
      Neuroscience, King's College London, London, UK; South London and Maudsley 
      National Health Service Foundation Trust, Bethlem Royal Hospital, UK. Electronic 
      address: jonathan.rogers@kcl.ac.uk.
FAU - Pollak, Thomas A
AU  - Pollak TA
AD  - Department of Psychosis Studies, Institute of Psychiatry, Psychology and 
      Neuroscience, King's College London, London, UK; South London and Maudsley 
      National Health Service Foundation Trust, Bethlem Royal Hospital, UK.
FAU - Blackman, Graham
AU  - Blackman G
AD  - Department of Psychosis Studies, Institute of Psychiatry, Psychology and 
      Neuroscience, King's College London, London, UK; South London and Maudsley 
      National Health Service Foundation Trust, Bethlem Royal Hospital, UK.
FAU - David, Anthony S
AU  - David AS
AD  - Institute of Mental Health, University College London, London, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190610
PL  - England
TA  - Lancet Psychiatry
JT  - The lancet. Psychiatry
JID - 101638123
SB  - IM
CIN - Lancet Psychiatry. 2019 Jul;6(7):554-555. PMID: 31196792
MH  - Catatonia/*complications/*immunology/physiopathology
MH  - Humans
MH  - Immune System/immunology/physiopathology
MH  - Immune System Diseases/*complications/immunology/*physiopathology
PMC - PMC7185541
EDAT- 2019/06/15 06:00
MHDA- 2019/11/05 06:00
PMCR- 2019/06/10
CRDT- 2019/06/15 06:00
PHST- 2018/06/20 00:00 [received]
PHST- 2019/03/27 00:00 [revised]
PHST- 2019/04/04 00:00 [accepted]
PHST- 2019/06/15 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2019/06/15 06:00 [entrez]
PHST- 2019/06/10 00:00 [pmc-release]
AID - S2215-0366(19)30190-7 [pii]
AID - 10.1016/S2215-0366(19)30190-7 [doi]
PST - ppublish
SO  - Lancet Psychiatry. 2019 Jul;6(7):620-630. doi: 10.1016/S2215-0366(19)30190-7. 
      Epub 2019 Jun 10.