PMID- 31197703
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20220531
IS  - 1590-1262 (Electronic)
IS  - 1124-4909 (Linking)
VI  - 25
IP  - 4
DP  - 2020 Aug
TI  - The interaction between dietary inflammatory index and 6 P21 rs2010963 gene 
      variants in metabolic syndrome.
PG  - 1049-1060
LID - 10.1007/s40519-019-00729-1 [doi]
AB  - BACKGROUND: The Vascular endothelial growth factor (VEGF) regulates endothelial 
      cell proliferation, migration and angiogenesis, promotes vascular and capillary 
      permeability and also is involved in inflammation. VEGF gene has been suggested 
      to play an important role in the pathogenesis of metabolic syndrome. The aim of 
      this study was to investigate the association between inflammatory potential of a 
      diet and + 405 VEGF C/G (rs2010963) polymorphism and metabolic components in 
      patients with metabolic syndrome. METHODS: One hundred fifty patients with 
      metabolic syndrome and fifty healthy individuals were enrolled. A 
      semi-quantitative food-frequency questionnaire (FFQ) was used for dietary 
      assessments and dietary inflammatory index (DII) calculation. Biochemical assays 
      including fasting serum glucose (FSG), serum insulin, matrix metalloproteinase-3 
      (MMP-3), liver enzymes and lipid profile were measured. Polymerase chain 
      reaction-restriction fragments length polymorphism (PCR-RFLP) method was used for 
      the determination of gene polymorphism. RESULTS: In the current study, patients 
      with metabolic syndrome had higher serum low density lipoprotein (LDL) and lower 
      high density lipoprotein (HDL) concentrations compared with healthy subjects. 
      Patients with lower DII quartiles and lower inflammatory potential of the diet 
      had lower waist to hip ratio (WHR) and lower diastolic blood pressure (DBP) 
      compared with patients in higher DII quartiles (P < 0.05). Moreover, patients and 
      healthy subjects in second quartile of DII had significantly higher aspartate 
      aminotransferase (AST) and alanine aminotransferase (ALT) concentrations compared 
      with subjects in the first quartile; also healthy subjects in third quartile had 
      significantly higher triglyceride (TG) and total cholesterol (TC) concentrations 
      compared with subjects in second quartile (P < 0.05). Among different genotypes 
      of 6 P21 rs2010963 gene variants in patients with metabolic syndrome, CC genotype 
      indicated the highest DII compared with other genotypes (P < 0.05). CONCLUSION: 
      The current study revealed the association between DII and metabolic risk factors 
      of metabolic syndrome. LEVEL OF EVIDENCE: Level III, case-control analytic study.
FAU - Abbasalizad Farhangi, Mahdieh
AU  - Abbasalizad Farhangi M
AD  - Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 
      abbasalizad_m@yahoo.com.
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. abbasalizad_m@yahoo.com.
FAU - Vajdi, Mahdi
AU  - Vajdi M
AD  - Research Center for Evidence Based Medicine, Health Management and Safety 
      Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Nikniaz, Leila
AU  - Nikniaz L
AD  - Tabriz Health Services Management Research Center, Health Management and Safety 
      Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Nikniaz, Zeinab
AU  - Nikniaz Z
AD  - Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20190613
PL  - Germany
TA  - Eat Weight Disord
JT  - Eating and weight disorders : EWD
JID - 9707113
RN  - 0 (Triglycerides)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Diet
MH  - Humans
MH  - Inflammation
MH  - *Metabolic Syndrome/genetics
MH  - Triglycerides
MH  - Vascular Endothelial Growth Factor A/*genetics
MH  - Waist-Hip Ratio
OTO - NOTNLM
OT  - Dietary Inflammatory Index
OT  - Genotype
OT  - Metabolic syndrome
OT  - Vascular endothelial growth factor
EDAT- 2019/06/15 06:00
MHDA- 2021/06/24 06:00
CRDT- 2019/06/15 06:00
PHST- 2019/04/15 00:00 [received]
PHST- 2019/06/05 00:00 [accepted]
PHST- 2019/06/15 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2019/06/15 06:00 [entrez]
AID - 10.1007/s40519-019-00729-1 [pii]
AID - 10.1007/s40519-019-00729-1 [doi]
PST - ppublish
SO  - Eat Weight Disord. 2020 Aug;25(4):1049-1060. doi: 10.1007/s40519-019-00729-1. 
      Epub 2019 Jun 13.