PMID- 31198666
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2211-5072 (Electronic)
IS  - 2211-5056 (Print)
IS  - 2211-5056 (Linking)
VI  - 9
IP  - 2
DP  - 2019 Apr-Jun
TI  - Polypoidal choroidal vasculopathy: An update on current management and review of 
      literature.
PG  - 72-92
LID - 10.4103/tjo.tjo_35_18 [doi]
AB  - Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related 
      macular degeneration (nAMD), commonly seen in the Asian population. It is 
      dissimilar in epidemiology, genetic heterogeneity, pathogenesis, natural history, 
      and response to treatment in comparison to nAMD. Confocal scanning laser 
      ophthalmoscopy-based simultaneous fluorescein angiography and indocyanine green 
      angiography, spectral-domain optical coherence tomography (OCT) with enhanced 
      depth imaging, swept-source OCT, and OCT angiography have improved the ability to 
      detect PCV, understand its pathology, and monitor treatment response. A plethora 
      of literature has discussed the efficacy of photodynamic therapy, anti-vascular 
      endothelial growth factor (VEGF) monotherapy, and combination of both, but only a 
      few studies with higher level of evidence and limited follow-up duration are 
      available. This review discusses the understanding of PCV with respect to 
      epidemiology, pathogenesis, clinical features, natural history, imaging 
      techniques, and various treatment options. Recent clinical trials (EVEREST-II and 
      PLANET study) have emphasized that either anti-VEGF monotherapy or combination 
      treatment is equally capable to strike a balance between polyp regression and 
      stabilization of visual acuity. The recurrent nature of the disease, the 
      development of macular atrophy, and the long-term poor visual prognosis despite 
      treatment are concerns that open avenues for further research.
FAU - Palkar, Amit Harishchandra
AU  - Palkar AH
AD  - Department of Vitreoretinal Services, Shri Bhagwan Mahavir Vitreoretinal 
      Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
FAU - Khetan, Vikas
AU  - Khetan V
AD  - Department of Vitreoretinal Services, Shri Bhagwan Mahavir Vitreoretinal 
      Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Taiwan J Ophthalmol
JT  - Taiwan journal of ophthalmology
JID - 101582127
PMC - PMC6557071
OTO - NOTNLM
OT  - Epidemiology
OT  - imaging
OT  - natural history
OT  - pathogenesis
OT  - polypoidal choroidal vasculopathy
OT  - treatment
COIS- The authors declare that there are no conflicts of interests of this paper.
EDAT- 2019/06/15 06:00
MHDA- 2019/06/15 06:01
PMCR- 2019/04/01
CRDT- 2019/06/15 06:00
PHST- 2019/06/15 06:00 [entrez]
PHST- 2019/06/15 06:00 [pubmed]
PHST- 2019/06/15 06:01 [medline]
PHST- 2019/04/01 00:00 [pmc-release]
AID - TJO-9-72 [pii]
AID - 10.4103/tjo.tjo_35_18 [doi]
PST - ppublish
SO  - Taiwan J Ophthalmol. 2019 Apr-Jun;9(2):72-92. doi: 10.4103/tjo.tjo_35_18.