PMID- 31199776
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210215
IS  - 2191-0200 (Electronic)
IS  - 0334-1763 (Linking)
VI  - 30
IP  - 7
DP  - 2019 Oct 25
TI  - Pathological and cognitive changes in patients with type 2 diabetes mellitus and 
      comorbid MCI and protective hypoglycemic therapies: a narrative review.
PG  - 757-770
LID - 10.1515/revneuro-2018-0083 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is becoming a significant health issue worldwide. 
      Many studies support the hypothesis that patients with T2DM have a 
      higher-than-expected incidence of mild cognitive impairment (MCI) than 
      individuals without diabetes. Based on the results from recent studies, MCI might 
      be associated with the effects of T2DM on glucose metabolism and brain atrophy. 
      As a narrative review, we will illuminate pathological and cognitive changes in 
      patients with T2DM and comorbid MCI and protective hypoglycemic therapies. The 
      early abnormal signs of cognition must be elucidated, and extensive 
      investigations are needed to develop improved therapies for use in the clinic.
CI  - (c) 2019 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Zhang, Xiao
AU  - Zhang X
AD  - The First Affiliated Hospital of Dalian Medical University, Dalian 116000, P.R. 
      China.
FAU - Huang-Fu, Zhao
AU  - Huang-Fu Z
AD  - The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, P.R. 
      China.
FAU - Lang, Xing-Ying
AU  - Lang XY
AD  - Dalian Center for Disease Control and Prevention, Dalian 116021, P.R. China.
FAU - Chun, Pu
AU  - Chun P
AD  - Department of Anatomy, College of Basic Medicine, Dalian Medical University, 
      Dalian 16044, P.R. China.
FAU - Chi, Yan-Yan
AU  - Chi YY
AD  - Department of Anatomy, College of Basic Medicine, Dalian Medical University, 
      Dalian 16044, P.R. China.
FAU - Yuan, Xiao-Ying
AU  - Yuan XY
AD  - Department of Anatomy, College of Basic Medicine, Dalian Medical University, 
      Dalian 16044, P.R. China.
FAU - Wang, Xu-Gang
AU  - Wang XG
AD  - Department of Neurology, The Second Affiliated Hospital of Dalian Medical 
      University, Dalian 116027, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190613
PL  - Germany
TA  - Rev Neurosci
JT  - Reviews in the neurosciences
JID - 8711016
SB  - IM
OTO - NOTNLM
OT  - cognition
OT  - hypoglycemic therapy
OT  - mild cognitive impairment
OT  - pathology
OT  - type 2 diabetes mellitus
EDAT- 2019/06/15 06:00
MHDA- 2019/06/15 06:01
CRDT- 2019/06/15 06:00
PHST- 2018/08/13 00:00 [received]
PHST- 2019/01/30 00:00 [accepted]
PHST- 2019/06/15 06:00 [pubmed]
PHST- 2019/06/15 06:01 [medline]
PHST- 2019/06/15 06:00 [entrez]
AID - /j/revneuro.ahead-of-print/revneuro-2018-0083/revneuro-2018-0083.xml [pii]
AID - 10.1515/revneuro-2018-0083 [doi]
PST - epublish
SO  - Rev Neurosci. 2019 Jun 13;30(7):757-770. doi: 10.1515/revneuro-2018-0083. Print 
      2019 Oct 25.