PMID- 31201558
OWN - NLM
STAT- MEDLINE
DCOM- 20200812
LR  - 20200812
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 259
DP  - 2020
TI  - Functions of Nuclear Polyphosphoinositides.
PG  - 163-181
LID - 10.1007/164_2019_219 [doi]
AB  - Despite interest in phosphoinositide (PtdIns) kinases, such as PtdIns 3 kinases 
      (PI3K), as targets for controlling plasma membrane PtdIns levels in disease, the 
      PtdIns have another less well-known site of action in the cell nucleus.Recent 
      studies show that PtdIns use a variety of strategies to alter DNA responses. 
      Here, we provide an overview of these newly identified forms of gene expression 
      control, which should be considered when studying the therapeutic use of 
      PtdIns-directed compounds. As PI3K is one of the most important clinical targets 
      in recent years, we will focus on two polyphosphoinositides, the PI3K substrate 
      PtdIns(4,5)di-phosphate (PI4,5P(2)) and its product PtdIns(3,4,5)tri-phosphate 
      (PI3,4,5P(3)).
FAU - Olazabal-Moran, Manuel
AU  - Olazabal-Moran M
AD  - Department of Immunology and Oncology, Centro Nacional de Biotecnologia/CSIC, 
      Madrid, Spain.
FAU - Gonzalez-Garcia, Ana
AU  - Gonzalez-Garcia A
AD  - Department of Immunology and Oncology, Centro Nacional de Biotecnologia/CSIC, 
      Madrid, Spain.
FAU - Carrera, Ana C
AU  - Carrera AC
AD  - Department of Immunology and Oncology, Centro Nacional de Biotecnologia/CSIC, 
      Madrid, Spain. acarrera@cnb.csic.es.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Phosphatidylinositol Phosphates)
RN  - 0 (Phosphatidylinositols)
SB  - IM
MH  - Cell Membrane/*chemistry
MH  - Cell Nucleus/*chemistry
MH  - Humans
MH  - Phosphatidylinositol 3-Kinases
MH  - Phosphatidylinositol Phosphates/*physiology
MH  - Phosphatidylinositols/*physiology
OTO - NOTNLM
OT  - Chromatin remodeling
OT  - Gene expression
OT  - Lipid transport proteins
OT  - Nuclear lipids
OT  - Nuclear phosphoinositide
OT  - PI3,4,5P3
OT  - PI3K
OT  - PI4,5P2
OT  - Phosphoinositide transport proteins
EDAT- 2019/06/16 06:00
MHDA- 2020/08/13 06:00
CRDT- 2019/06/16 06:00
PHST- 2019/06/16 06:00 [pubmed]
PHST- 2020/08/13 06:00 [medline]
PHST- 2019/06/16 06:00 [entrez]
AID - 10.1007/164_2019_219 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2020;259:163-181. doi: 10.1007/164_2019_219.