PMID- 31202195
OWN - NLM
STAT- MEDLINE
DCOM- 20200220
LR  - 20200220
IS  - 1532-8198 (Electronic)
IS  - 1092-9134 (Linking)
VI  - 41
DP  - 2019 Aug
TI  - Calcifying fibrous tumor and inflammatory myofibroblastic tumor are 
      epigenetically related: A comparative genome-wide methylation study.
PG  - 102-105
LID - S1092-9134(19)30181-9 [pii]
LID - 10.1016/j.anndiagpath.2019.05.013 [doi]
AB  - Based on histological findings, calcifying fibrous tumor (CFT) may be a late 
      (burned out) stage of inflammatory myofibroblastic tumor (IMT). This concept, 
      however, has not been proven by molecular means. Five CFTs were analyzed for 
      IMT-related rearrangements in ALK, ROS1 and RET using fluorescence in situ 
      hybridization (FISH). Additionally, genome-wide methylation patterns were 
      investigated and compared with IMT (n = 7), leiomyoma (n = 7), angioleiomyoma 
      (n = 9), myopericytoma (n = 7) and reactive soft tissue lesions (n = 10) using 
      unsupervised hierarchical cluster analysis and t distributed stochastic neighbor 
      embedding. CFT patients, 4 females and 1 male, had a median age of 20 years 
      ranging from 7 to 43 years. Two patients were younger than 18 years old. The 
      tumors originated in the abdomen (n = 4) and axilla (n = 1). Histologically, all 
      lesions were (multi) nodular and hypocellular consisting of bland looking 
      (myo)fibroblasts embedded in a collagenous matrix with calcifications. FISH 
      analysis brought up negative results for ALK, RET and ROS1 rearrangements. 
      However, genome-wide methylation analysis revealed overlapping methylation 
      patterns of CFT and IMT forming a distinct homogeneous methylation cluster with 
      exception of one case clustering with myopericytoma/angioleiomyoma. In 
      conclusion, DNA methylation profiling supports the concept that CFT and IMT 
      represent both ends of a spectrum of one entity with CFT being the burn out stage 
      of IMT.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Tomassen, Tess
AU  - Tomassen T
AD  - Department of Pathology, Radboud University Medical Center, Nijmegen, the 
      Netherlands.
FAU - Koelsche, Christian
AU  - Koelsche C
AD  - Department of General Pathology, Institute of Pathology, University Hospital 
      Heidelberg, Heidelberg, Germany.
FAU - de Leng, Wendy W J
AU  - de Leng WWJ
AD  - Department of Pathology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Kommoss, Felix K F
AU  - Kommoss FKF
AD  - Department of General Pathology, Institute of Pathology, University Hospital 
      Heidelberg, Heidelberg, Germany.
FAU - Voijs, Carmen M A
AU  - Voijs CMA
AD  - Department of Pathology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Peeters, Ton
AU  - Peeters T
AD  - Department of Pathology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - van Noesel, Max M
AU  - van Noesel MM
AD  - Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.
FAU - Creytens, David
AU  - Creytens D
AD  - Department of Pathology, Ghent University and Gent University Hospital, Ghent, 
      Belgium.
FAU - van Gorp, Joost M
AU  - van Gorp JM
AD  - Department of Pathology, St Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Petersen, Iver
AU  - Petersen I
AD  - Institute of Pathology, SRH Wald-Klinikum Gera, Germany.
FAU - Vokuhl, Christian
AU  - Vokuhl C
AD  - Kiel Paediatric Tumor Registry and Institute of Pathology, Christian Albrechts 
      University, Kiel, Germany.
FAU - von Deimling, Andreas
AU  - von Deimling A
AD  - Department of Neuropathology, Institute of Pathology, Heidelberg University 
      Hospital, Heidelberg, Germany.
FAU - Mentzel, Thomas
AU  - Mentzel T
AD  - Dermatopathology Bodensee, Friedrichshafen, Germany.
FAU - Flucke, Uta
AU  - Flucke U
AD  - Department of Pathology, Radboud University Medical Center, Nijmegen, the 
      Netherlands; Princess Maxima Center for Pediatric Oncology, Utrecht, the 
      Netherlands. Electronic address: uta.flucke@radboudumc.nl.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190603
PL  - United States
TA  - Ann Diagn Pathol
JT  - Annals of diagnostic pathology
JID - 9800503
SB  - IM
MH  - Abdominal Neoplasms/genetics/pathology
MH  - Adolescent
MH  - Adult
MH  - Axilla/pathology
MH  - Calcinosis/genetics/pathology
MH  - Child
MH  - DNA Methylation
MH  - Epigenesis, Genetic
MH  - Female
MH  - Genome-Wide Association Study
MH  - Granuloma, Plasma Cell/*genetics/pathology
MH  - Humans
MH  - Male
MH  - Neoplasms, Fibrous Tissue/*genetics/pathology
MH  - Young Adult
OTO - NOTNLM
OT  - Calcifying fibrous tumor
OT  - Fluorescence in situ hybridization
OT  - Genome-wide methylation profiling
OT  - Inflammatory myofibroblastic tumor
EDAT- 2019/06/16 06:00
MHDA- 2020/02/23 06:00
CRDT- 2019/06/16 06:00
PHST- 2019/05/21 00:00 [received]
PHST- 2019/05/31 00:00 [accepted]
PHST- 2019/06/16 06:00 [pubmed]
PHST- 2020/02/23 06:00 [medline]
PHST- 2019/06/16 06:00 [entrez]
AID - S1092-9134(19)30181-9 [pii]
AID - 10.1016/j.anndiagpath.2019.05.013 [doi]
PST - ppublish
SO  - Ann Diagn Pathol. 2019 Aug;41:102-105. doi: 10.1016/j.anndiagpath.2019.05.013. 
      Epub 2019 Jun 3.