PMID- 31202429
OWN - NLM
STAT- MEDLINE
DCOM- 20200213
LR  - 20200213
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 56
IP  - 3
DP  - 2019 Jul
TI  - Haploidentical donor transplants for severe aplastic anemia.
PG  - 190-193
LID - S0037-1963(18)30169-0 [pii]
LID - 10.1053/j.seminhematol.2019.03.004 [doi]
AB  - Haploidentical stem cell transplantation (HAPLO) is being increasingly used, and 
      significant progress has been made both with ex vivo T-cell depleted grafts as 
      well as with unmanipulated marrow or peripheral blood grafts. We here review the 
      current status of HAPLO grafts in patients with acquired severe aplastic anemia. 
      Several transplant platforms have been tested, to overcome graft severe rejection 
      and graft vs host disease (GvHD): these include differences in the conditioning 
      regimen, in graft source and graft manipulation, and in GvHD prophylaxis. The 
      latter include ex vivo T-cell depletion and/or antithymocyte globulin and/or high 
      dose post-transplant cyclophosphamide. Some programs also include the use of 
      marrow or cord blood mesenchymal stem cells, infused at the time of 
      transplantation. Extremely encouraging results are being reported especially in 
      the pediatric population, but also in young adults: we will review reports on 375 
      patients, with an average rejection rate of 6%, grade II-IV GvHD of 23% and 
      1-year survival of 80%. Finally we will discuss the place of HAPLO transplants in 
      the context of alternative donor grafts for acquired aplastic anemia.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Bacigalupo, Andrea
AU  - Bacigalupo A
AD  - Department of Hematology, Fondazione Policlinico Universitario Gemelli IRCCS, 
      Universita' Cattolica del Sacro Cuore, Roma, Italy. Electronic address: 
      apbacigalupo@yahoo.com.
FAU - Giammarco, Sabrina
AU  - Giammarco S
AD  - Department of Hematology, Fondazione Policlinico Universitario Gemelli IRCCS, 
      Universita' Cattolica del Sacro Cuore, Roma, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190326
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
SB  - IM
MH  - Adolescent
MH  - Anemia, Aplastic/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Male
MH  - Tissue Donors
MH  - Transplantation Conditioning/*methods
MH  - Young Adult
EDAT- 2019/06/17 06:00
MHDA- 2020/02/14 06:00
CRDT- 2019/06/17 06:00
PHST- 2018/10/04 00:00 [received]
PHST- 2019/03/18 00:00 [accepted]
PHST- 2019/06/17 06:00 [entrez]
PHST- 2019/06/17 06:00 [pubmed]
PHST- 2020/02/14 06:00 [medline]
AID - S0037-1963(18)30169-0 [pii]
AID - 10.1053/j.seminhematol.2019.03.004 [doi]
PST - ppublish
SO  - Semin Hematol. 2019 Jul;56(3):190-193. doi: 10.1053/j.seminhematol.2019.03.004. 
      Epub 2019 Mar 26.