PMID- 31202680
OWN - NLM
STAT- MEDLINE
DCOM- 20200302
LR  - 20200302
IS  - 1535-7732 (Electronic)
IS  - 1051-0443 (Linking)
VI  - 30
IP  - 11
DP  - 2019 Nov
TI  - Experience with Compressed Gelfoam Plugs in Children during Liver Biopsies and 
      Other IR Procedures: A Retrospective Single-Center Case Series.
PG  - 1855-1862
LID - S1051-0443(19)30370-7 [pii]
LID - 10.1016/j.jvir.2019.04.004 [doi]
AB  - PURPOSE: To analyze the experience using compressed gelfoam plugs (CGPs) in 
      children during liver biopsies and other interventional procedures. MATERIALS AND 
      METHODS: This was a single-center, retrospective, consecutive case series of 477 
      various pediatric interventional radiology procedures using CGPs (January 2012 to 
      December 2016) performed on 397 children (209 males, 188 females; median age, 7 
      years [range, 9 days-17.8 years]; median weight, 18 kg [range, 2.7-141 kg]). Of 
      477 procedures, most (n = 371) were liver biopsies, 98 were biopsies of other 
      organs, and 8 were non-biopsy procedures. Analysis focused on liver biopsies. 
      RESULTS: Of liver biopsies, a median of 2 CGPs were used per procedure, and the 
      mean drop in hemoglobin was -0.36 g/dl (-3.0% change). Thirty-seven mild, 8 
      moderate, 2 severe, and 1 life-threatening (an anaphylaxis to CGP) adverse events 
      (AEs) occurred. Analysis of liver biopsies with AEs showed significant 
      association between number of passes, cores, and focal-type lesions (unadjusted 
      logistic regression: P = .007, P = .022, P = .028, respectively) and age, weight, 
      and number of passes (adjusted multiple logistic regression: P = .006, P = .032, 
      P = .046, respectively). Technical problems relating to CGP deployment were noted 
      in 5 (1%), without any AEs. CONCLUSIONS: CGPs were used in a wide variety of 
      procedures and organs in children. There was 1 life-threatening AE resulting from 
      the rare risk of anaphylaxis caused by the gelfoam-containing plug. After liver 
      biopsies, transfusion was required in 2/371 (0.5%) procedures, 1 related to 
      pre-biopsy anemia (0.25%).
CI  - Copyright (c) 2019 SIR. Published by Elsevier Inc. All rights reserved.
FAU - McDonald, Julian
AU  - McDonald J
AD  - Department of Diagnostic Imaging, Division of Image Guided Therapy, The Hospital 
      for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 
      1X8, Canada; University of Edinburgh Medical School, Edinburgh, United Kingdom. 
      Electronic address: julianmnmcdonald@gmail.com.
FAU - Amirabadi, Afsaneh
AU  - Amirabadi A
AD  - Department of Diagnostic Imaging, Division of Image Guided Therapy, The Hospital 
      for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 
      1X8, Canada.
FAU - Farhat, Ziad
AU  - Farhat Z
AD  - Department of Diagnostic Imaging, IWK Health Centre, Dalhousie University Faculty 
      of Medicine, Halifax, Canada.
FAU - Temple, Michael
AU  - Temple M
AD  - Department of Diagnostic Imaging, Division of Image Guided Therapy, The Hospital 
      for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 
      1X8, Canada.
FAU - Parra, Dimitri
AU  - Parra D
AD  - Department of Diagnostic Imaging, Division of Image Guided Therapy, The Hospital 
      for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 
      1X8, Canada.
FAU - Amaral, Joao
AU  - Amaral J
AD  - Department of Diagnostic Imaging, Division of Image Guided Therapy, The Hospital 
      for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 
      1X8, Canada.
FAU - Connolly, Bairbre
AU  - Connolly B
AD  - Department of Diagnostic Imaging, Division of Image Guided Therapy, The Hospital 
      for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 
      1X8, Canada.
LA  - eng
PT  - Journal Article
DEP - 20190613
PL  - United States
TA  - J Vasc Interv Radiol
JT  - Journal of vascular and interventional radiology : JVIR
JID - 9203369
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Anaphylaxis/chemically induced
MH  - Biopsy, Large-Core Needle
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gelatin Sponge, Absorbable/*administration & dosage/adverse effects
MH  - Hemorrhage/etiology/*prevention & control
MH  - Humans
MH  - *Image-Guided Biopsy/adverse effects
MH  - Infant
MH  - Infant, Newborn
MH  - Liver Diseases/*pathology
MH  - Male
MH  - Ontario
MH  - *Radiography, Interventional/adverse effects
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2019/06/17 06:00
MHDA- 2020/03/03 06:00
CRDT- 2019/06/17 06:00
PHST- 2018/10/27 00:00 [received]
PHST- 2019/03/09 00:00 [revised]
PHST- 2019/04/02 00:00 [accepted]
PHST- 2019/06/17 06:00 [pubmed]
PHST- 2020/03/03 06:00 [medline]
PHST- 2019/06/17 06:00 [entrez]
AID - S1051-0443(19)30370-7 [pii]
AID - 10.1016/j.jvir.2019.04.004 [doi]
PST - ppublish
SO  - J Vasc Interv Radiol. 2019 Nov;30(11):1855-1862. doi: 10.1016/j.jvir.2019.04.004. 
      Epub 2019 Jun 13.