PMID- 31202840
OWN - NLM
STAT- MEDLINE
DCOM- 20190919
LR  - 20190919
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 231
DP  - 2019 Aug 15
TI  - Prospects for the application of mesenchymal stem cells in Alzheimer's disease 
      treatment.
PG  - 116564
LID - S0024-3205(19)30490-4 [pii]
LID - 10.1016/j.lfs.2019.116564 [doi]
AB  - Alzheimer's disease (AD) as a dementia and neurodegenerative disease, is mostly 
      prevalent among people more than 65 years. AD is mostly manifested in the form of 
      degraded mental function, such as losing memory and impaired cognitive function. 
      Due to inefficiency of traditional pharmacological therapeutic approaches with no 
      long-term cure, cell therapy can be considered as a capable approach in AD 
      management. Therapies based on mesenchymal stem cells (MSCs) have provided 
      hopeful results in experimental models regarding several disorders. MSCs enhance 
      the levels of functional recoveries in pathologic experimental models of central 
      nervous system (CNS) and are being investigated in clinical trials in 
      neurological disorders. However, there is limited knowledge on the protective 
      capabilities of MSCs in AD management. Almost, several experiments have suggested 
      positive effects of MSCs and helped to better understand of AD-related dementia 
      mechanism. MSCs have the potential to be used in AD treatment through amyloid-beta 
      peptide (AB), Tau protein and cholinergic system. This review aimed to clarify 
      the promising perspective of MSCs in the context of AD.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Chakari-Khiavi, Forough
AU  - Chakari-Khiavi F
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 
      Pharmaceutical Chemistry, Faculty of Pharmacy, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Dolati, Sanam
AU  - Dolati S
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 
      Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 
      Aging Research Institute, Tabriz University of Medical Sciences Tabriz, Iran.
FAU - Chakari-Khiavi, Aref
AU  - Chakari-Khiavi A
AD  - Aging Research Institute, Tabriz University of Medical Sciences Tabriz, Iran.
FAU - Abbaszadeh, Hossein
AU  - Abbaszadeh H
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Aghebati-Maleki, Leili
AU  - Aghebati-Maleki L
AD  - Immunology Research Center, Tabriz university of Medical Sciences, Tabriz, Iran.
FAU - Pourlak, Tannaz
AU  - Pourlak T
AD  - Aging Research Institute, Tabriz University of Medical Sciences Tabriz, Iran.
FAU - Mehdizadeh, Amir
AU  - Mehdizadeh A
AD  - Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Yousefi, Mehdi
AU  - Yousefi M
AD  - Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 
      Aging Research Institute, Tabriz University of Medical Sciences Tabriz, Iran; 
      Department of Immunology, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.. Electronic address: Yousefime@tbzmed.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190613
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
SB  - IM
MH  - Alzheimer Disease/*therapy
MH  - Animals
MH  - Humans
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mesenchymal Stem Cells/cytology/physiology
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Cell therapy
OT  - Central nervous system
OT  - Mesenchymal stem cells
EDAT- 2019/06/17 06:00
MHDA- 2019/09/20 06:00
CRDT- 2019/06/17 06:00
PHST- 2019/06/08 00:00 [received]
PHST- 2019/06/11 00:00 [revised]
PHST- 2019/06/11 00:00 [accepted]
PHST- 2019/06/17 06:00 [pubmed]
PHST- 2019/09/20 06:00 [medline]
PHST- 2019/06/17 06:00 [entrez]
AID - S0024-3205(19)30490-4 [pii]
AID - 10.1016/j.lfs.2019.116564 [doi]
PST - ppublish
SO  - Life Sci. 2019 Aug 15;231:116564. doi: 10.1016/j.lfs.2019.116564. Epub 2019 Jun 
      13.