PMID- 31203167
OWN - NLM
STAT- MEDLINE
DCOM- 20190925
LR  - 20190925
IS  - 1879-1514 (Electronic)
IS  - 0166-445X (Linking)
VI  - 213
DP  - 2019 Aug
TI  - Mixture toxicity effects and uptake of titanium dioxide (TiO(2)) nanoparticles 
      and 3,3',4,4'-tetrachlorobiphenyl (PCB77) in juvenile brown trout following 
      co-exposure via the diet.
PG  - 105195
LID - S0166-445X(18)31129-9 [pii]
LID - 10.1016/j.aquatox.2019.04.021 [doi]
AB  - Titanium dioxide nanoparticles (n-TiO(2)) are among the man-made nanomaterials 
      that are predicted to be found at high concentrations in the aquatic environment. 
      There, they likely co-exist with other chemical pollutants. Thus, n-TiO(2) and 
      other chemical pollutants can be taken up together or accumulate independently 
      from each other in prey organisms of fish. This can lead to dietary exposure of 
      fish to n-TiO(2)-chemical pollutant mixtures. In this study, we examine if 
      simultaneous dietary exposure to n-TiO(2) and 3,3',4,4'-Tetrachlorobiphenyl 
      (PCB77) -used as a model compound for persistent organic pollutants with 
      dioxin-like properties- can influence the uptake and toxicological response 
      elicited by the respective other substance. Juvenile brown trout (Salmo trutta) 
      were fed custom-made food pellets containing n-TiO(2,) PCB77 or n-TiO(2)+PCB77 
      mixtures for 15 days. Ti and PCB77 concentrations in the liver were measured by 
      ICP-MS and GC-MS, respectively. Besides, n-TiO(2) uptake was assessed using TEM. 
      Combination effects on endpoints specific for PCB77 (i.e., cytochrome P450 1A 
      (CYP1A) induction) and endpoints shared by both PCB77 and n-TiO(2) (i.e., 
      oxidative stress-related parameters) were measured in intestine and liver using 
      RT-qPCR and enzyme activity assays. The results show that genes encoding for 
      proteins/enzymes essential for tight junction function (zo-1) and ROS elimination 
      (sod-1) were significantly upregulated in the intestine of fish exposed to 
      n-TiO(2) and PCB77 mixtures, but not in the single-substance treatments. Besides, 
      n-TiO(2) had a potentiating effect on PCB77-induced CYP1A and glutathione 
      reductase (GR) expression/enzyme activity in the liver. This study shows that 
      simultaneous dietary exposure to nanomaterials and traditional environmental 
      pollutants might result in effects that are larger than observed for the 
      substances alone, but that understanding the mechanistic basis of such effects 
      remains challenging.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Lammel, Tobias
AU  - Lammel T
AD  - Department of Biological and Environmental Sciences, Gothenburg University, 
      Sweden. Electronic address: tobias.lammel@gu.se.
FAU - Wassmur, Britt
AU  - Wassmur B
AD  - Department of Biological and Environmental Sciences, Gothenburg University, 
      Sweden.
FAU - Mackevica, Aiga
AU  - Mackevica A
AD  - TU Environment, Technical University of Denmark, Denmark.
FAU - Chen, Chang-Er L
AU  - Chen CL
AD  - Department of Environmental Sciences and Analytical Chemistry, Stockholm 
      University, Sweden; Environmental Research Institute, South China Normal 
      University, Guangzhou 510006, China.
FAU - Sturve, Joachim
AU  - Sturve J
AD  - Department of Biological and Environmental Sciences, Gothenburg University, 
      Sweden.
LA  - eng
PT  - Journal Article
DEP - 20190530
PL  - Netherlands
TA  - Aquat Toxicol
JT  - Aquatic toxicology (Amsterdam, Netherlands)
JID - 8500246
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Messenger)
RN  - 0 (Water Pollutants, Chemical)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 9038-94-2 (Metallothionein)
RN  - D1JT611TNE (Titanium)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - Y2I6546TMI (3,4,3',4'-tetrachlorobiphenyl)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cytochrome P-450 CYP1A1/genetics/metabolism
MH  - *Diet
MH  - *Environmental Exposure
MH  - Feeding Behavior
MH  - Gene Expression Regulation/drug effects
MH  - Intestines/drug effects
MH  - Liver/drug effects/metabolism/ultrastructure
MH  - Metallothionein/metabolism
MH  - Nanoparticles/*toxicity/ultrastructure
MH  - Oxidative Stress/drug effects
MH  - Polychlorinated Biphenyls/*toxicity
MH  - RNA, Messenger/genetics/metabolism
MH  - Titanium/*toxicity
MH  - Trout/*physiology
MH  - Water Pollutants, Chemical/toxicity
OTO - NOTNLM
OT  - Accumulation
OT  - Co-contaminant
OT  - Fish
OT  - Metal oxide
OT  - Nanomaterial
OT  - Persistent organic pollutant
EDAT- 2019/06/17 06:00
MHDA- 2019/09/26 06:00
CRDT- 2019/06/17 06:00
PHST- 2018/12/22 00:00 [received]
PHST- 2019/04/10 00:00 [revised]
PHST- 2019/04/29 00:00 [accepted]
PHST- 2019/06/17 06:00 [pubmed]
PHST- 2019/09/26 06:00 [medline]
PHST- 2019/06/17 06:00 [entrez]
AID - S0166-445X(18)31129-9 [pii]
AID - 10.1016/j.aquatox.2019.04.021 [doi]
PST - ppublish
SO  - Aquat Toxicol. 2019 Aug;213:105195. doi: 10.1016/j.aquatox.2019.04.021. Epub 2019 
      May 30.