PMID- 31205547
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 10
IP  - 8
DP  - 2019
TI  - Up-regulated of Angiopoietin-Like Protein 4 Predicts Poor Prognosis in Cervical 
      Cancer.
PG  - 1896-1901
LID - 10.7150/jca.29916 [doi]
AB  - Background: Angiopoietin-like protein 4 (ANGPTL4) has been demonstrated highly 
      expressed in some cancers, but it also was downregulated in others through DNA 
      methylation. However, the expression status of ANGPTL4 in cancer of cervix 
      remains unclear. Thus, our present study attempts to investigate the role of 
      ANGPTL4 in the prognosis of patients with cervical cancer. Methods: 
      Immunohistochemistry, western blotting and qRT-PCR were performed to investigate 
      the expressive level of ANPGTL4 in cervical cancer tissues and paired noncancer 
      tissues. The relationship of ANGPTL4 expression and clinicopathological factors 
      was measured by Chi-square test. Overall and disease-free survival (OS and DFS) 
      rates were estimated and compared by using Kaplan-Meier method and log-rank test, 
      respectively. To assess the prognostic significance of ANGPTL4 in cervical cancer 
      patients, the Cox regression model was utilized to process univariate and 
      multivariate analyses. Results: ANGPTL4 was upregulated in cervical cancer 
      samples and advanced tumor stage, deep stromal invasion, lymph node metastasis, 
      lymphovascular space invasion, as well as poor OS and DFS were shown to be 
      tightly correlated with it. Results of Cox multivariate analysis demonstrated 
      that ANGPTL4 expression was an independent prognostic factor for OS and DFS in 
      cervical cancer. Conclusion: Upregulated ANGPTL4 seems to be a useful marker for 
      poor prognosis in cervical cancer.
FAU - Nie, Dan
AU  - Nie D
AD  - Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and 
      Related Diseases of Women and Children, Ministry of Education, West China Second 
      University Hospital, Sichuan University, Chengdu,610041, People's Republic of 
      China.
AD  - Department of Gynecology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, People's Republic of China.
FAU - Zheng, Qianwen
AU  - Zheng Q
AD  - Department of Gynecology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, People's Republic of China.
FAU - Liu, Ling
AU  - Liu L
AD  - Department of Gynecology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, People's Republic of China.
FAU - Mao, Xiguang
AU  - Mao X
AD  - Department of Gynecology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, People's Republic of China.
FAU - Li, Zhengyu
AU  - Li Z
AD  - Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and 
      Related Diseases of Women and Children, Ministry of Education, West China Second 
      University Hospital, Sichuan University, Chengdu,610041, People's Republic of 
      China.
LA  - eng
PT  - Journal Article
DEP - 20190421
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC6547978
OTO - NOTNLM
OT  - angiopoietin-like protein 4
OT  - cervical cancer
OT  - prognosis
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2019/06/18 06:00
MHDA- 2019/06/18 06:01
PMCR- 2019/01/01
CRDT- 2019/06/18 06:00
PHST- 2018/09/13 00:00 [received]
PHST- 2019/02/23 00:00 [accepted]
PHST- 2019/06/18 06:00 [entrez]
PHST- 2019/06/18 06:00 [pubmed]
PHST- 2019/06/18 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - jcav10p1896 [pii]
AID - 10.7150/jca.29916 [doi]
PST - epublish
SO  - J Cancer. 2019 Apr 21;10(8):1896-1901. doi: 10.7150/jca.29916. eCollection 2019.