PMID- 31205772
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2076-3417 (Print)
IS  - 2076-3417 (Electronic)
IS  - 2076-3417 (Linking)
VI  - 7
IP  - 12
DP  - 2017 Dec
TI  - Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope.
LID - 1241 [pii]
LID - 10.3390/app7121241 [doi]
AB  - It is highly desirable to develop novel approaches to improve patient survival 
      rate of pancreatic cancer through early detection. Here, we present such an 
      approach based on photoacoustic and fluorescence molecular imaging of pancreatic 
      tumor using a miniature multimodal endoscope in combination with targeted 
      multifunctional iron oxide nanoparticles (IONPs). A novel fan-shaped scanning 
      mechanism was developed to minimize the invasiveness for endoscopic imaging of 
      pancreatic tumors. The results show that the enhancements in photoacoustic and 
      fluorescence signals using amino-terminal fragment (ATF) targeted IONPs were 
      ~four to six times higher compared to that using non-targeted IONPs. Our study 
      indicates the potential of the combination of the multimodal 
      photoacoustic-fluorescence endoscopy and targeted multifunctional nanoparticles 
      as an efficient tool to provide improved specificity and sensitivity for 
      pancreatic cancer detection.
FAU - Dai, Xianjin
AU  - Dai X
AD  - J. Crayton Pruitt Family Department of Biomedical Engineering, University of 
      Florida, Gainesville, FL 32611, USA.
FAU - Qian, Weiping
AU  - Qian W
AD  - Departments of Surgery, Emory University School of Medicine, Atlanta, GA 30322, 
      USA.
FAU - Yang, Hao
AU  - Yang H
AD  - Department of Medical Engineering, University of South Florida, Tampa, FL 33620, 
      USA.
FAU - Yang, Lily
AU  - Yang L
AD  - Departments of Surgery, Emory University School of Medicine, Atlanta, GA 30322, 
      USA.
AD  - Departments of Radiology and Imaging Sciences, Emory University School of 
      Medicine, Atlanta, GA 30322, USA.
FAU - Jiang, Huabei
AU  - Jiang H
AD  - Department of Medical Engineering, University of South Florida, Tampa, FL 33620, 
      USA.
LA  - eng
GR  - U01 CA151810/CA/NCI NIH HHS/United States
GR  - U01 CA198913/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20171130
PL  - Switzerland
TA  - Appl Sci (Basel)
JT  - Applied sciences (Basel, Switzerland)
JID - 101633495
PMC - PMC6570408
MID - NIHMS972567
OTO - NOTNLM
OT  - fluorescence imaging
OT  - molecular imaging
OT  - multifunctional nanoparticles
OT  - multimodal endoscopy
OT  - pancreatic cancer
OT  - photoacoustic imaging
COIS- Conflicts of Interest: The authors declare no conflict of interest. The founding 
      sponsors had no role in the design of the study; in the collection, analyses, or 
      interpretation of data; in the writing of the manuscript, and in the decision to 
      publish the results.
EDAT- 2017/12/01 00:00
MHDA- 2017/12/01 00:01
PMCR- 2019/06/14
CRDT- 2019/06/18 06:00
PHST- 2019/06/18 06:00 [entrez]
PHST- 2017/12/01 00:00 [pubmed]
PHST- 2017/12/01 00:01 [medline]
PHST- 2019/06/14 00:00 [pmc-release]
AID - 1241 [pii]
AID - 10.3390/app7121241 [doi]
PST - ppublish
SO  - Appl Sci (Basel). 2017 Dec;7(12):1241. doi: 10.3390/app7121241. Epub 2017 Nov 30.