PMID- 31205951
OWN - NLM
STAT- MEDLINE
DCOM- 20200124
LR  - 20200225
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2019
DP  - 2019
TI  - Effects of Genetic Variants of Nuclear Receptor Y on the Risk of Type 2 Diabetes 
      Mellitus.
PG  - 4902301
LID - 10.1155/2019/4902301 [doi]
LID - 4902301
AB  - Nuclear factor-Y (NF-Y) consists of three evolutionary conserved subunits 
      including NF-YA, NF-YB, and NF-YC; it is a critical transcriptional regulator of 
      lipid and glucose metabolism and adipokine biosynthesis that are associated with 
      type 2 diabetes mellitus (T2DM) occurrence, while the impacts of genetic variants 
      in the NF-Y gene on the risk of T2DM remain to be investigated. In the present 
      study, we screened five single-nucleotide polymorphisms (SNPs) with the SNaPshot 
      method in 427 patients with T2DM and 408 healthy individuals. Subsequently, we 
      analyzed the relationships between genotypes and haplotypes constructed from 
      these SNPs with T2DM under diverse genetic models. Furthermore, we investigated 
      the allele effects on the quantitative metabolic traits. Of the five tagSNPs, we 
      found that three SNPs (rs2268188, rs6918969, and rs28869187) exhibited nominal 
      significant differences in allelic or genotypic frequency between patients with 
      T2DM and healthy individuals. The minor alleles G, C, and C at rs2268188, 
      rs6918969, and rs28869187, respectively, conferred a higher T2DM risk under a 
      dominant genetic model, and the carriers of these risk alleles (either 
      homozygotes of the minor allele or heterozygotes) had statistically higher levels 
      of fasting plasma glucose, cholesterol, and triglycerides. Haplotype analysis 
      showed that SNPs rs2268188, rs6918969, rs28869187, and rs35105472 formed a 
      haplotype block, and haplotype TTAC was protective against T2DM (OR = 0.76, 95% 
      CI = 0.33-0.82, P = 0.004), while haplotype GCCG was associated with an elevated 
      susceptibility to T2DM (OR = 2.33, 95% CI = 1.43-3.57, P = 0.001). This study is 
      the first ever observation to our knowledge that indicates the genetic variants 
      of NF-YA might influence a Chinese Han individual's occurrence of T2DM.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Geriatric Medicine and National Clinical Research Center for 
      Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
FAU - Yang, Shanshan
AU  - Yang S
AD  - Molecular Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Guan, Qiuyue
AU  - Guan Q
AD  - Department of Geriatrics, People's Hospital of Sichuan Province, Chengdu, 610041 
      Sichuan, China.
FAU - Chen, Jinglu
AU  - Chen J
AD  - Molecular Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Zhang, Xueping
AU  - Zhang X
AD  - Molecular Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Zhang, Yuwei
AU  - Zhang Y
AD  - Division of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041, China.
FAU - Yuan, Yiming
AU  - Yuan Y
AD  - Department of Geriatric Medicine and National Clinical Research Center for 
      Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
FAU - Su, Zhiguang
AU  - Su Z
AUID- ORCID: 0000-0001-8635-9310
AD  - Molecular Medicine Research Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
LA  - eng
PT  - Journal Article
DEP - 20190507
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Blood Glucose)
RN  - 0 (CCAAT-Binding Factor)
RN  - 0 (NFYA protein, human)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - CCAAT-Binding Factor/*genetics
MH  - China
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genes, Dominant
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Genotype
MH  - Glucose/*metabolism
MH  - Haplotypes
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Linkage Disequilibrium
MH  - *Lipid Metabolism
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Triglycerides/blood
PMC - PMC6530108
EDAT- 2019/06/18 06:00
MHDA- 2020/01/25 06:00
PMCR- 2019/05/07
CRDT- 2019/06/18 06:00
PHST- 2018/12/20 00:00 [received]
PHST- 2019/03/04 00:00 [accepted]
PHST- 2019/06/18 06:00 [entrez]
PHST- 2019/06/18 06:00 [pubmed]
PHST- 2020/01/25 06:00 [medline]
PHST- 2019/05/07 00:00 [pmc-release]
AID - 10.1155/2019/4902301 [doi]
PST - epublish
SO  - J Diabetes Res. 2019 May 7;2019:4902301. doi: 10.1155/2019/4902301. eCollection 
      2019.