PMID- 31207167
OWN - NLM
STAT- MEDLINE
DCOM- 20200115
LR  - 20210109
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 7
IP  - 3
DP  - 2019 Sep
TI  - The allergic phenotype during the first 10 years of life in a prospective cohort.
PG  - 170-182
LID - 10.1002/iid3.255 [doi]
AB  - BACKGROUND: Heredity and environmental parameters jointly affect allergy 
      development. Here, we used a Swedish prospective cohort to study the influence of 
      heredity and factors usually associated with allergic disease and the development 
      of allergic manifestations in combination with immunoglobulin E (IgE) 
      sensitization at four different time points until 10 years of age. METHODS: 
      Parents-to-be were characterized concerning allergy and their children (n = 281) 
      were divided based on allergic heredity and followed from birth and clinically 
      examined for IgE-associated allergic symptoms until 10 years of age. The relation 
      between allergy and early-life parameters was analyzed by logistic regression. 
      Group-wise comparisons were made by nonparametrical tests. RESULTS: Early life 
      eczema and/or asthma in combination with IgE sensitization, was a strong 
      indicator of allergy at a later time point. Further, the early occurrence of 
      multiple allergic symptoms among IgE-sensitized children predisposed for a more 
      complex allergic phenotype at later ages, independently of allergic heredity. At 
      10 years of age, allergic children had higher fractional exhaled nitrogen oxide 
      (FeNO) levels, regardless of asthma, and FeNO levels were also influenced by 
      heredity. Birth season was strongly associated with allergy development, but only 
      in children with two allergic parents. CONCLUSION: Allergic eczema/asthma in 
      early life, being born during the autumn/winter, having multiple allergic 
      symptoms and two allergic parents were all strong predictors for having allergic 
      diseases at 5 and 10 years of age. However, the allergic march seems to be 
      independent of heredity, as IgE-mediated allergies follow the same trajectories 
      in children with and without allergic heredity.
CI  - (c) 2019 The Authors. Immunity, Inflammation and Disease published by John Wiley & 
      Sons Ltd.
FAU - Bjorkander, Sophia
AU  - Bjorkander S
AD  - Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm 
      University, Stockholm, Sweden.
FAU - Hallberg, Jenny
AU  - Hallberg J
AD  - Department of Clinical Science and Education, Sodersjukhuset, Karolinska 
      Institutet, Stockholm, Sweden.
AD  - Sachs' Children and Youth Hospital, Stockholm, Sweden.
AD  - Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Persson, Jan-Olov
AU  - Persson JO
AD  - Department of Mathematics, Stockholm University, Stockholm, Sweden.
FAU - Lilja, Gunnar
AU  - Lilja G
AD  - Department of Clinical Science and Education, Sodersjukhuset, Karolinska 
      Institutet, Stockholm, Sweden.
AD  - Sachs' Children and Youth Hospital, Stockholm, Sweden.
FAU - Nilsson, Caroline
AU  - Nilsson C
AD  - Department of Clinical Science and Education, Sodersjukhuset, Karolinska 
      Institutet, Stockholm, Sweden.
AD  - Sachs' Children and Youth Hospital, Stockholm, Sweden.
FAU - Sverremark-Ekstrom, Eva
AU  - Sverremark-Ekstrom E
AUID- ORCID: 0000-0001-6271-8681
AD  - Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm 
      University, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190617
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Asthma/diagnosis/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Eczema/diagnosis/*immunology
MH  - Exhalation
MH  - Female
MH  - Humans
MH  - Hypersensitivity/diagnosis/*immunology
MH  - Immunoglobulin E/*immunology
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Nitric Oxide/immunology/metabolism
MH  - Parents
MH  - Phenotype
MH  - Prospective Studies
PMC - PMC6688083
OTO - NOTNLM
OT  - FeNO
OT  - allergy
OT  - birth season
OT  - childhood
OT  - early predictors of allergy
OT  - lung function
OT  - parental allergy
OT  - prospective cohort
COIS- The authors declare that there are no conflict of interests.
EDAT- 2019/06/18 06:00
MHDA- 2020/01/16 06:00
PMCR- 2019/06/17
CRDT- 2019/06/18 06:00
PHST- 2019/03/12 00:00 [received]
PHST- 2019/05/09 00:00 [revised]
PHST- 2019/05/16 00:00 [accepted]
PHST- 2019/06/18 06:00 [pubmed]
PHST- 2020/01/16 06:00 [medline]
PHST- 2019/06/18 06:00 [entrez]
PHST- 2019/06/17 00:00 [pmc-release]
AID - IID3255 [pii]
AID - 10.1002/iid3.255 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2019 Sep;7(3):170-182. doi: 10.1002/iid3.255. Epub 2019 Jun 
      17.