PMID- 31207311
OWN - NLM
STAT- MEDLINE
DCOM- 20190919
LR  - 20231104
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 231
DP  - 2019 Aug 15
TI  - Light at night exacerbates metabolic dysfunction in a polygenic mouse model of 
      type 2 diabetes mellitus.
PG  - 116574
LID - S0024-3205(19)30500-4 [pii]
LID - 10.1016/j.lfs.2019.116574 [doi]
AB  - AIMS: Electric lighting is beneficial to modern society; however, it is becoming 
      apparent that light at night (LAN) is not without biological consequences. 
      Several studies have reported negative effects of LAN on health and behavior in 
      humans and nonhuman animals. Exposure of non-diabetic mice to dim LAN impairs 
      glucose tolerance, whereas a return to dark nights (LD) reverses this impairment. 
      We predicted that exposure to LAN would exacerbate the metabolic abnormalities in 
      TALLYHO/JngJ (TH) mice, a polygenic model of type 2 diabetes mellitus (T2DM). 
      MATERIALS AND METHODS: We exposed 7-week old male TH mice to either LD or LAN for 
      8-10 weeks in two separate experiments. After 8 weeks of light treatment, we 
      conducted intraperitoneal glucose tolerance testing (ipGTT) followed by 
      intraperitoneal insulin tolerance testing (ipITT). In Experiment 1, all mice were 
      returned to LD for 4 weeks, and ipITT was repeated. KEY FINDINGS: The major 
      results of this study are i) LAN exposure for 8 weeks exacerbates glucose 
      intolerance and insulin resistance ii) the effects of LAN on insulin resistance 
      are reversed upon return to LD, iii) LAN exposure results in a greater increase 
      in body weight compared to LD exposure, iv) LAN increases the incidence of mice 
      developing overt T2DM, and v) LAN exposure decreases survival of mice with T2DM. 
      SIGNIFICANCE: In conclusion, LAN exacerbated metabolic abnormalities in a 
      polygenic mouse model of T2DM, and these effects were reversed upon return to 
      dark nights. The applicability of these findings to humans with T2DM needs to be 
      determined.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Russart, Kathryn L G
AU  - Russart KLG
AD  - Department of Neuroscience, The Ohio State University Wexner Medical Center, 
      Columbus, OH 43210, USA. Electronic address: kathryn.russart@osumc.edu.
FAU - Chbeir, Souhad A
AU  - Chbeir SA
AD  - Department of Neuroscience, The Ohio State University Wexner Medical Center, 
      Columbus, OH 43210, USA.
FAU - Nelson, Randy J
AU  - Nelson RJ
AD  - Department of Neuroscience, West Virginia University, Morgantown, WV 26505, USA.
FAU - Magalang, Ulysses J
AU  - Magalang UJ
AD  - Department of Neuroscience, The Ohio State University Wexner Medical Center, 
      Columbus, OH 43210, USA; Department of Internal Medicine, The Ohio State 
      University Wexner Medical Center, Columbus, OH 43210, USA.
LA  - eng
GR  - R01 NS092388/NS/NINDS NIH HHS/United States
GR  - R21 CA202745/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20190614
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Baroreflex
MH  - Blood Glucose/*metabolism
MH  - Blood Pressure
MH  - Body Weight
MH  - Circadian Rhythm/physiology
MH  - Diabetes Mellitus, Type 2/blood/*metabolism/physiopathology
MH  - Disease Models, Animal
MH  - Glucose Intolerance/metabolism
MH  - Glucose Tolerance Test
MH  - Heart Rate
MH  - Hemodynamics
MH  - Insulin/blood
MH  - Insulin Resistance/physiology
MH  - Light
MH  - Lighting/*adverse effects
MH  - Male
MH  - Mice
MH  - Norepinephrine
MH  - Weight Gain
PMC - PMC6689263
MID - NIHMS1532595
OTO - NOTNLM
OT  - Diabetes
OT  - Glucose tolerance
OT  - Insulin resistance
OT  - Light at night
OT  - Metabolic dysfunction
COIS- Conflict of Interest The authors have no personal, professional, or financial 
      relationships that could potentially be construed as a conflict of interest.
EDAT- 2019/06/18 06:00
MHDA- 2019/09/20 06:00
PMCR- 2020/08/15
CRDT- 2019/06/18 06:00
PHST- 2019/04/12 00:00 [received]
PHST- 2019/06/10 00:00 [revised]
PHST- 2019/06/13 00:00 [accepted]
PHST- 2019/06/18 06:00 [pubmed]
PHST- 2019/09/20 06:00 [medline]
PHST- 2019/06/18 06:00 [entrez]
PHST- 2020/08/15 00:00 [pmc-release]
AID - S0024-3205(19)30500-4 [pii]
AID - 10.1016/j.lfs.2019.116574 [doi]
PST - ppublish
SO  - Life Sci. 2019 Aug 15;231:116574. doi: 10.1016/j.lfs.2019.116574. Epub 2019 Jun 
      14.