PMID- 31207579
OWN - NLM
STAT- MEDLINE
DCOM- 20200128
LR  - 20200128
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 117
DP  - 2019 Sep
TI  - MicroRNA-98-HMGA2-POSTN signal pathway reverses epithelial-to-mesenchymal 
      transition in laryngeal squamous cell carcinoma.
PG  - 108998
LID - S0753-3322(19)31022-4 [pii]
LID - 10.1016/j.biopha.2019.108998 [doi]
AB  - It has been widely considered that reversing epithelial-to-mesenchymal transition 
      (EMT) is a potential access to restrain cancer progression and therapeutic 
      resistance. Here, we aim to uncover the novel mechanisms by which we can reverse 
      EMT and inhibit metastasis in laryngeal squamous cell carcinoma (LSCC). We show 
      that miR-98 is significantly reduced in both LSCC specimens and cell lines. 
      Over-expression of miR-98 inhibits the EMT-related gene expression and metastasis 
      and invasive behavior in LSCC in vitro, as well as reduces lung metastasis in 
      mouse model. In the mechanistically study, miR-98 directly targets HMGA2 in 
      mediating EMT. HMGA2 knock down by si-RNA method declines several EMT-related 
      genes expression and LSCC migration and invasion. In parallel, overexpression of 
      HMGA2 transforms LSCC cells to acquire stem cell-like features. Furthermore, we 
      reveal that HMGA2-mediated EMT is closely linked with the expression of POSTN 
      that inhibits EMT, as a tumor suppressor, by gene profiling analyses. POSTN is 
      transcriptionally repressed by HMGA2. In clinic, the HMGA2 mRNA level is 
      negatively correlated with the miR-98 level in LSCC patient cohort. In 
      conclusion, our study confers a powerful signal: miR-98-HMGA-POSTN in LSCC, which 
      is able to reverse EMT and inhibit metastasis, underlining the therapeutic 
      potential of this signal.
CI  - Copyright (c) 2019. Published by Elsevier Masson SAS.
FAU - Zhu, Minhui
AU  - Zhu M
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Changhai Hospital, the 
      Second Military Medical University, No. 168 Changhai Road, Shanghai, 200433, 
      People's Republic of China.
FAU - Zhang, Caiyun
AU  - Zhang C
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Changhai Hospital, the 
      Second Military Medical University, No. 168 Changhai Road, Shanghai, 200433, 
      People's Republic of China.
FAU - Chen, Donghui
AU  - Chen D
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Changhai Hospital, the 
      Second Military Medical University, No. 168 Changhai Road, Shanghai, 200433, 
      People's Republic of China.
FAU - Chen, Shicai
AU  - Chen S
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Changhai Hospital, the 
      Second Military Medical University, No. 168 Changhai Road, Shanghai, 200433, 
      People's Republic of China.
FAU - Zheng, Hongliang
AU  - Zheng H
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Changhai Hospital, the 
      Second Military Medical University, No. 168 Changhai Road, Shanghai, 200433, 
      People's Republic of China. Electronic address: zhenghongliangpdd@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190615
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (HMGA2 Protein)
RN  - 0 (MIRN98 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (POSTN protein, human)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Cell Adhesion Molecules/genetics/*metabolism
MH  - Cell Line, Tumor
MH  - Epithelial-Mesenchymal Transition/*genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - HMGA2 Protein/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - Mice
MH  - MicroRNAs/genetics/*metabolism
MH  - Neoplasm Metastasis
MH  - Neoplastic Stem Cells/metabolism/pathology
MH  - *Signal Transduction
OTO - NOTNLM
OT  - Epithelial-To-mesenchymal transition
OT  - HMGA
OT  - Laryngeal squamous cell carcinoma
OT  - POSTN
OT  - miR-98
EDAT- 2019/06/18 06:00
MHDA- 2020/01/29 06:00
CRDT- 2019/06/18 06:00
PHST- 2019/03/09 00:00 [received]
PHST- 2019/05/14 00:00 [revised]
PHST- 2019/05/14 00:00 [accepted]
PHST- 2019/06/18 06:00 [pubmed]
PHST- 2020/01/29 06:00 [medline]
PHST- 2019/06/18 06:00 [entrez]
AID - S0753-3322(19)31022-4 [pii]
AID - 10.1016/j.biopha.2019.108998 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2019 Sep;117:108998. doi: 10.1016/j.biopha.2019.108998. Epub 
      2019 Jun 15.