PMID- 31207920 OWN - NLM STAT- MEDLINE DCOM- 20200106 LR - 20211204 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 11 IP - 6 DP - 2019 Jun 14 TI - ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. LID - 10.3390/nu11061340 [doi] LID - 1340 AB - Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile. FAU - Barja-Fernandez, Silvia AU - Barja-Fernandez S AD - Endocrine Physiopathology Group, Instituto Investigacion Sanitaria Santiago de Compostela (IDIS), Complejo Hospitalario Universitario Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. sylvia_barfer@hotmail.com. AD - Pediatrics Department, GI Nutricion Pediatrica (IDIS, CHUS), Galician Human Development, Growth and Nutrition Research Unit, Universidad Santiago de Compostela (USC), 15706 Santiago de Compostela, Spain. sylvia_barfer@hotmail.com. AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. sylvia_barfer@hotmail.com. FAU - Folgueira, Cintia AU - Folgueira C AUID- ORCID: 0000-0003-3803-9149 AD - Endocrine Physiopathology Group, Instituto Investigacion Sanitaria Santiago de Compostela (IDIS), Complejo Hospitalario Universitario Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. cintiafolgueira@gmail.com. AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. cintiafolgueira@gmail.com. AD - Department Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Health Research Institute of Santiago USC-IDIS, University Santiago de Compostela, 15705 Santiago de Compostela, Spain. cintiafolgueira@gmail.com. FAU - Castelao, Cecilia AU - Castelao C AD - Endocrine Physiopathology Group, Instituto Investigacion Sanitaria Santiago de Compostela (IDIS), Complejo Hospitalario Universitario Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. ceciliacastelao@hotmail.com. AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. ceciliacastelao@hotmail.com. FAU - Pena-Leon, Veronica AU - Pena-Leon V AD - Endocrine Physiopathology Group, Instituto Investigacion Sanitaria Santiago de Compostela (IDIS), Complejo Hospitalario Universitario Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. veritoloren@hotmail.com. AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. veritoloren@hotmail.com. FAU - Gonzalez-Saenz, Patricia AU - Gonzalez-Saenz P AD - Endocrine Physiopathology Group, Instituto Investigacion Sanitaria Santiago de Compostela (IDIS), Complejo Hospitalario Universitario Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. pepsieg@gmail.com. AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. pepsieg@gmail.com. FAU - Vazquez-Cobela, Rocio AU - Vazquez-Cobela R AD - Pediatrics Department, GI Nutricion Pediatrica (IDIS, CHUS), Galician Human Development, Growth and Nutrition Research Unit, Universidad Santiago de Compostela (USC), 15706 Santiago de Compostela, Spain. cobela.rocio@gmail.com. FAU - Aguilera, Concepcion M AU - Aguilera CM AUID- ORCID: 0000-0002-1451-4788 AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. caguiler@ugr.es. AD - Biochemistry and Molecular Biology II Department, University Granada, 18001 Granada, Spain. caguiler@ugr.es. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. mercedes_gil_campos@yahoo.es. AD - Paediatric Research and Metabolism Unit, University Hospital Reina Sofia, 14004 Cordoba, Spain. mercedes_gil_campos@yahoo.es. FAU - Bueno, Gloria AU - Bueno G AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. gbuenoloz@yahoo.es. AD - Pediatric Department, University Hospital Lozano Blesa, 50009 Zaragoza, Spain. gbuenoloz@yahoo.es. FAU - Gil, Angel AU - Gil A AUID- ORCID: 0000-0001-7663-0939 AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. agil@ugr.es. AD - Biochemistry and Molecular Biology II Department, University Granada, 18001 Granada, Spain. agil@ugr.es. FAU - Moreno, Luis A AU - Moreno LA AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. lmoreno@unizar.es. AD - GENUD (Growth, Exercise, Nutrition and Development research group, Universidad de Zaragoza, Instituto Agroalimentario de Aragon (IA2) and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), 50009 Zaragoza, Spain. lmoreno@unizar.es. FAU - Ruiz-Pinon, Manuel AU - Ruiz-Pinon M AD - Endocrine Physiopathology Group, Instituto Investigacion Sanitaria Santiago de Compostela (IDIS), Complejo Hospitalario Universitario Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. manuelc.ruiz@usc.es. AD - Operative Dentistry and Endodontics, USC, 15782 Santiago de Compostela, Spain. manuelc.ruiz@usc.es. FAU - Garcia-Palacios, Maria AU - Garcia-Palacios M AD - Endocrine Physiopathology Group, Instituto Investigacion Sanitaria Santiago de Compostela (IDIS), Complejo Hospitalario Universitario Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. maria.garcia.palacios@gmail.com. AD - Department Pediatric Surgery, University Santiago de Compostela USC, 15705 Santiago de Compostela, Spain. maria.garcia.palacios@gmail.com. FAU - Casanueva, Felipe F AU - Casanueva FF AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. felipe.casanueva@usc.es. AD - Laboratory of Molecular and Cellular Endocrinology, University Santiago de Compostela USC, 15706 Santiago de Compostela, Spain. felipe.casanueva@usc.es. FAU - Dieguez, Carlos AU - Dieguez C AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. carlos.dieguez@usc.es. AD - Department Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Health Research Institute of Santiago USC-IDIS, University Santiago de Compostela, 15705 Santiago de Compostela, Spain. carlos.dieguez@usc.es. FAU - Nogueiras, Ruben AU - Nogueiras R AUID- ORCID: 0000-0002-9976-9930 AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. ruben.nogueiras@usc.es. AD - Department Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Health Research Institute of Santiago USC-IDIS, University Santiago de Compostela, 15705 Santiago de Compostela, Spain. ruben.nogueiras@usc.es. FAU - Leis, Rosaura AU - Leis R AD - Pediatrics Department, GI Nutricion Pediatrica (IDIS, CHUS), Galician Human Development, Growth and Nutrition Research Unit, Universidad Santiago de Compostela (USC), 15706 Santiago de Compostela, Spain. mariarosaura.leis@usc.es. AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. mariarosaura.leis@usc.es. FAU - Seoane, Luisa M AU - Seoane LM AD - Endocrine Physiopathology Group, Instituto Investigacion Sanitaria Santiago de Compostela (IDIS), Complejo Hospitalario Universitario Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain. luisamaria.seoane@usc.es. AD - CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto Salud Carlos III, 28029 Madrid, Spain. luisamaria.seoane@usc.es. LA - eng GR - PI18/00998, PI15/01272, PI11/02042, PI16/01301, PI16/00871/Instituto de Salud Carlos III/ GR - Not number/Fundacion Mutua Madrilena/ PT - Journal Article DEP - 20190614 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (ANGPTL4 protein, human) RN - 0 (Angiopoietin-Like Protein 4) RN - 0 (Lipids) SB - IM MH - Adolescent MH - Angiopoietin-Like Protein 4/*blood MH - Body Mass Index MH - Child MH - Child, Preschool MH - Cross-Sectional Studies MH - Humans MH - Ideal Body Weight/physiology MH - Lipids/*blood MH - Longitudinal Studies MH - Obesity/*blood/*epidemiology PMC - PMC6628529 OTO - NOTNLM OT - ANGPTL-4 OT - BMI loss OT - childhood OT - lipid profile OT - obesity COIS- The authors declare no conflict of interest. EDAT- 2019/06/19 06:00 MHDA- 2020/01/07 06:00 PMCR- 2019/06/01 CRDT- 2019/06/19 06:00 PHST- 2019/05/07 00:00 [received] PHST- 2019/06/06 00:00 [revised] PHST- 2019/06/06 00:00 [accepted] PHST- 2019/06/19 06:00 [entrez] PHST- 2019/06/19 06:00 [pubmed] PHST- 2020/01/07 06:00 [medline] PHST- 2019/06/01 00:00 [pmc-release] AID - nu11061340 [pii] AID - nutrients-11-01340 [pii] AID - 10.3390/nu11061340 [doi] PST - epublish SO - Nutrients. 2019 Jun 14;11(6):1340. doi: 10.3390/nu11061340.