PMID- 31208474
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20200527
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Print)
IS  - 0007-1145 (Linking)
VI  - 122
IP  - 4
DP  - 2019 Aug 28
TI  - Circulating calcium levels and the risk of type 2 diabetes: a systematic review 
      and meta-analysis.
PG  - 376-387
LID - 10.1017/S0007114519001430 [doi]
AB  - Abnormal Ca homeostasis has been associated with impaired glucose metabolism. 
      However, the epidemiological evidence is controversial. We aimed to assess the 
      association between circulating Ca levels and the risk of type 2 diabetes 
      mellitus (T2DM) or abnormal glucose homeostasis through conducting a systematic 
      review and meta-analysis. Eligible studies were identified by searching 
      electronic database (PubMed, Embase and Google Scholar) and related references 
      with de novo results from primary studies up to December 2018. A random-effects 
      meta-analysis was performed to estimate the weighted relative risks (RR) and 95 % 
      CI for the associations. The search yielded twenty eligible publications with 
      eight cohort studies identified for the meta-analysis, which included a total of 
      89 165 participants. Comparing the highest with the lowest category of 
      albumin-adjusted serum Ca, the pooled RR was 1.14 (95 % CI 1.05, 1.24) for T2DM 
      (n 51 489). Similarly, serum total Ca was associated with incident T2DM (RR 1.25; 
      95 % CI 1.10, 1.42) (n 64 502). Additionally, the adjusted RR for 1 mg/dl 
      increments in albumin-adjusted serum Ca or serum total Ca levels was 1.16 (95 % 
      CI 1.07, 1.27) and 1.19 (95 % CI 1.11, 1.28), respectively. The observed 
      associations remained with the inclusion of a cohort study with ionised Ca as the 
      exposure. However, data pooled from neither case-control (n 4) nor 
      cross-sectional (n 8) studies manifested a significant correlation between 
      circulating Ca and glucose homeostasis. In conclusion, accumulated data from the 
      cohort studies suggest that higher circulating Ca levels are associated with an 
      augmented risk of T2DM.
FAU - Zhu, J
AU  - Zhu J
AD  - Department of Clinical Nutrition, Xin Hua Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, Shanghai 200092, People's Republic of China.
AD  - Department of Nutrition, Shanghai Jiao Tong University School of Medicine, 
      Shanghai 200025, People's Republic of China.
AD  - Nutrition and Foods Program, School of Family and Consumer Sciences, Texas State 
      University, San Marcos, TX 78666, USA.
FAU - Xun, P
AU  - Xun P
AD  - Department of Epidemiology and Biostatistics, School of Public 
      Health-Bloomington, Indiana University, Bloomington, IN 47405, USA.
FAU - Bae, J C
AU  - Bae JC
AD  - Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan 
      University School of Medicine, Changwon 630-723, Republic of Korea.
FAU - Kim, J H
AU  - Kim JH
AD  - Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul 06351, Republic of Korea.
FAU - Kim, D J
AU  - Kim DJ
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon 443-380, Republic of Korea.
FAU - Yang, K
AU  - Yang K
AD  - Department of Clinical Nutrition, Xin Hua Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, Shanghai 200092, People's Republic of China.
AD  - Department of Nutrition, Shanghai Jiao Tong University School of Medicine, 
      Shanghai 200025, People's Republic of China.
FAU - He, K
AU  - He K
AD  - Department of Epidemiology and Biostatistics, School of Public 
      Health-Bloomington, Indiana University, Bloomington, IN 47405, USA.
LA  - eng
GR  - R01 DK116603/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Homeostasis
MH  - Humans
MH  - Risk Factors
PMC - PMC6816042
MID - NIHMS1531851
OTO - NOTNLM
OT  - Blood calcium
OT  - Diabetes
OT  - Glucose
OT  - Insulin
OT  - Serum calcium
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2019/06/19 06:00
MHDA- 2020/05/28 06:00
PMCR- 2019/10/28
CRDT- 2019/06/19 06:00
PHST- 2019/06/19 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2019/06/19 06:00 [entrez]
PHST- 2019/10/28 00:00 [pmc-release]
AID - S0007114519001430 [pii]
AID - 10.1017/S0007114519001430 [doi]
PST - ppublish
SO  - Br J Nutr. 2019 Aug 28;122(4):376-387. doi: 10.1017/S0007114519001430.